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Murcko scaffold

Ring system with 3 rings and 16 atoms

24 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
24
With full pages
6
Scaffold SMILES

c1ccc(C2=Nc3cnccc3NC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(C2=Nc3cnccc3NC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 24 of 24 chemicals

Carbamic acid, 5-amino-1,2-dihydro-3-phenylpyrido(3,4-b)pyrazin-7-yl-, ethyl ester chemical structure, C16H17N5O2, CAS 82585-91-9
Carbamic acid, 5-amino-1,2-dihydro-3-phenylpyrido(3,4-b)pyrazin-7-yl-, ethyl ester
CAS 82585-91-9C16H17N5O2
Ethyl N-[5-amino-3-(4-chlorophenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate chemical structure, C16H16ClN5O2, CAS 82585-96-4
Ethyl N-[5-amino-3-(4-chlorophenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate
CAS 82585-96-4C16H16ClN5O2
Carbamic acid, (5-amino-3-(2,4-dichlorophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)-, ethyl ester chemical structure, C16H15Cl2N5O2, CAS 82585-97-5
Carbamic acid, (5-amino-3-(2,4-dichlorophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)-, ethyl ester
CAS 82585-97-5C16H15Cl2N5O2
CI 980 chemical structure, C17H19N5O2, CAS 82585-92-0
CI 980
CAS 82585-92-0C17H19N5O2
Carbamic acid, (5-amino-3-(3,4-dimethylphenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)-, ethyl ester chemical structure, C18H21N5O2, CAS 82585-94-2
Carbamic acid, (5-amino-3-(3,4-dimethylphenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)-, ethyl ester
CAS 82585-94-2C18H21N5O2
Carbamic acid, (5-amino-1,2-dihydro-1-methyl-3-phenylpyrido(3,4-b)pyrazin-7-yl)-, ethyl ester chemical structure, C17H19N5O2, CAS 83269-12-9
Carbamic acid, (5-amino-1,2-dihydro-1-methyl-3-phenylpyrido(3,4-b)pyrazin-7-yl)-, ethyl ester
CAS 83269-12-9C17H19N5O2
Carbamic acid, (5-amino-3-(4-fluorophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)-, ethyl ester chemical structure, C16H16FN5O2, CAS 82585-95-3
Carbamic acid, (5-amino-3-(4-fluorophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)-, ethyl ester
CAS 82585-95-3C16H16FN5O2
Ethyl (5-amino-3-(2,4-dimethylphenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)carbamate chemical structure, C18H21N5O2, CAS 82585-93-1
Ethyl (5-amino-3-(2,4-dimethylphenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)carbamate
CAS 82585-93-1C18H21N5O2
Ethyl N-(5-amino-2-methyl-3-phenyl-1,2-dihydropyrido[3,4-b]pyrazin-7-yl)carbamate chemical structure, C17H19N5O2, CAS 83269-10-7
Ethyl N-(5-amino-2-methyl-3-phenyl-1,2-dihydropyrido[3,4-b]pyrazin-7-yl)carbamate
CAS 83269-10-7C17H19N5O2
Carbamic acid, (5-amino-3-(3,4-dichlorophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)-, ethyl ester chemical structure, C16H15Cl2N5O2, CAS 82585-98-6
Carbamic acid, (5-amino-3-(3,4-dichlorophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)-, ethyl ester
CAS 82585-98-6C16H15Cl2N5O2
Carbamic acid, (5-amino-1,2-dihydro-3-(3-methoxyphenyl)pyrido(3,4-b)pyrazin-7-yl)-, ethyl ester chemical structure, C17H19N5O3, CAS 82585-99-7
Carbamic acid, (5-amino-1,2-dihydro-3-(3-methoxyphenyl)pyrido(3,4-b)pyrazin-7-yl)-, ethyl ester
CAS 82585-99-7C17H19N5O3
Carbamic acid, (5-amino-1,2-dihydro-3-(4-methoxyphenyl)pyrido(3,4-b)pyrazin-7-yl)-, ethyl ester chemical structure, C17H19N5O3, CAS 82586-00-3
Carbamic acid, (5-amino-1,2-dihydro-3-(4-methoxyphenyl)pyrido(3,4-b)pyrazin-7-yl)-, ethyl ester
CAS 82586-00-3C17H19N5O3
Carbamic acid, (5-amino-1,2-dihydro-3-(3,4,5-trimethoxyphenyl)pyrido(3,4-b)pyrazin-7-yl)-, ethyl ester chemical structure, C19H23N5O5, CAS 82586-01-4
Carbamic acid, (5-amino-1,2-dihydro-3-(3,4,5-trimethoxyphenyl)pyrido(3,4-b)pyrazin-7-yl)-, ethyl ester
CAS 82586-01-4C19H23N5O5
Carbamic acid, (5-amino-3-(4-aminophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)-, ethyl ester chemical structure, C16H18N6O2, CAS 82586-02-5
Carbamic acid, (5-amino-3-(4-aminophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)-, ethyl ester
CAS 82586-02-5C16H18N6O2
Carbamic acid, (5-amino-1,2-dihydro-3-(4-(trifluoromethyl)phenyl)pyrido(3,4-b)pyrazin-7-yl)-, ethyl ester chemical structure, C17H16F3N5O2, CAS 82586-03-6
Carbamic acid, (5-amino-1,2-dihydro-3-(4-(trifluoromethyl)phenyl)pyrido(3,4-b)pyrazin-7-yl)-, ethyl ester
CAS 82586-03-6C17H16F3N5O2
Ethyl (5-amino-1,2-dihydro-3-(2,3,4-trimethoxyphenyl)pyrido(3,4-b)pyrazin-7-yl)carbamate chemical structure, C19H23N5O5, CAS 87607-23-6
Ethyl (5-amino-1,2-dihydro-3-(2,3,4-trimethoxyphenyl)pyrido(3,4-b)pyrazin-7-yl)carbamate
CAS 87607-23-6C19H23N5O5
Ethyl (5-amino-3-(3,5-dimethoxyphenyl)-1,2-dihydro-2-methylpyrido(3,4-b)pyrazin-7-yl)carbamate chemical structure, C19H23N5O4, CAS 87607-26-9
Ethyl (5-amino-3-(3,5-dimethoxyphenyl)-1,2-dihydro-2-methylpyrido(3,4-b)pyrazin-7-yl)carbamate
CAS 87607-26-9C19H23N5O4
Ethyl (5-(acetylamino)-1,2-dihydro-3-phenylpyrido(3,4-b)pyrazin-7-yl)carbamate chemical structure, C18H19N5O3, CAS 87607-28-1
Ethyl (5-(acetylamino)-1,2-dihydro-3-phenylpyrido(3,4-b)pyrazin-7-yl)carbamate
CAS 87607-28-1C18H19N5O3
Pyrido(3,4-b)pyrazin-5-amine, 1,2-dihydro-3-phenyl- chemical structure, C13H12N4, CAS 87619-51-0
Pyrido(3,4-b)pyrazin-5-amine, 1,2-dihydro-3-phenyl-
CAS 87619-51-0C13H12N4
Mivobulin isethionate chemical structure, C19H25N5O6S, CAS 126268-81-3
Mivobulin isethionate
CAS 126268-81-3C19H25N5O6S
Mivobulin chemical structure, C17H19N5O2, CAS 122332-18-7
Mivobulin
CAS 122332-18-7C17H19N5O2
(5-Amino-1,2-dihydro-3-(4-methoxyphenyl)-2-methylpyrido(3,4-b)pyrazin-7-yl)carbamic acid ethyl ester chemical structure, C18H21N5O3, CAS 135696-54-7
(5-Amino-1,2-dihydro-3-(4-methoxyphenyl)-2-methylpyrido(3,4-b)pyrazin-7-yl)carbamic acid ethyl ester
CAS 135696-54-7C18H21N5O3
Ethyl N-(5-amino-2-ethyl-3-phenyl-1,2-dihydropyrido[3,4-b]pyrazin-7-yl)carbamate chemical structure, C18H21N5O2, CAS 135696-47-8
Ethyl N-(5-amino-2-ethyl-3-phenyl-1,2-dihydropyrido[3,4-b]pyrazin-7-yl)carbamate
CAS 135696-47-8C18H21N5O2
Ethyl [5-amino-3-(4-aminophenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate--hydrogen chloride (1/1) chemical structure, C16H19ClN6O2, CAS 84688-09-5
Ethyl [5-amino-3-(4-aminophenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate--hydrogen chloride (1/1)
CAS 84688-09-5C16H19ClN6O2