Murcko scaffold
Ring system with 3 rings and 22 atoms
35 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 22
- Chemicals
- 35
- With full pages
- 2
Scaffold SMILES
O=C(Nc1ccccc1)c1sccc1OCc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 35 of 35 chemicals
![N-(2-Chlorophenyl)-3-[(2,6-dichlorophenyl)methoxy]thiophene-2-carboxamide chemical structure, C18H12Cl3NO2S, CAS 344270-09-3](/s/SRMFLPXXRVOWJE-UHFFFAOYSA-N.svg)
N-(2-Chlorophenyl)-3-[(2,6-dichlorophenyl)methoxy]thiophene-2-carboxamide
CAS 344270-09-3C18H12Cl3NO2S
![N-(2-Chlorophenyl)-3-{[3-(trifluoromethyl)benzyl]oxy}-2-thiophenecarboxamide chemical structure, C19H13ClF3NO2S, CAS 344273-18-3](/s/YIQNOOBEGHCXSG-UHFFFAOYSA-N.svg)
N-(2-Chlorophenyl)-3-{[3-(trifluoromethyl)benzyl]oxy}-2-thiophenecarboxamide
CAS 344273-18-3C19H13ClF3NO2S
![3-[(2,4-Dichlorophenyl)methoxy]-N-(2,4-difluorophenyl)thiophene-2-carboxamide chemical structure, C18H11Cl2F2NO2S, CAS 339098-01-0](/s/VVBWAYXQJNPCOQ-UHFFFAOYSA-N.svg)
3-[(2,4-Dichlorophenyl)methoxy]-N-(2,4-difluorophenyl)thiophene-2-carboxamide
CAS 339098-01-0C18H11Cl2F2NO2S
![N-(4-Bromophenyl)-3-[(4-methoxyphenyl)methoxy]thiophene-2-carboxamide chemical structure, C19H16BrNO3S, CAS 339098-29-2](/s/RIRATKYZPATJBO-UHFFFAOYSA-N.svg)
N-(4-Bromophenyl)-3-[(4-methoxyphenyl)methoxy]thiophene-2-carboxamide
CAS 339098-29-2C19H16BrNO3S
![N-(4-Chlorophenyl)-3-[(4-methoxyphenyl)methoxy]thiophene-2-carboxamide chemical structure, C19H16ClNO3S, CAS 339098-32-7](/s/FLACUGYFGVWKDN-UHFFFAOYSA-N.svg)
N-(4-Chlorophenyl)-3-[(4-methoxyphenyl)methoxy]thiophene-2-carboxamide
CAS 339098-32-7C19H16ClNO3S
![N-(2,4-Difluorophenyl)-3-[(4-methoxyphenyl)methoxy]thiophene-2-carboxamide chemical structure, C19H15F2NO3S, CAS 339098-34-9](/s/XAPGCGVPNKCIBG-UHFFFAOYSA-N.svg)
N-(2,4-Difluorophenyl)-3-[(4-methoxyphenyl)methoxy]thiophene-2-carboxamide
CAS 339098-34-9C19H15F2NO3S
![3-[(4-Methoxybenzyl)oxy]-N-[4-(trifluoromethyl)phenyl]-2-thiophenecarboxamide chemical structure, C20H16F3NO3S, CAS 339098-36-1](/s/XKNVDTHKIGDHBO-UHFFFAOYSA-N.svg)
3-[(4-Methoxybenzyl)oxy]-N-[4-(trifluoromethyl)phenyl]-2-thiophenecarboxamide
CAS 339098-36-1C20H16F3NO3S
![3-[(4-Methoxybenzyl)oxy]-N-[3-(trifluoromethyl)phenyl]-2-thiophenecarboxamide chemical structure, C20H16F3NO3S, CAS 339098-38-3](/s/QBMHGXYQCKIGQQ-UHFFFAOYSA-N.svg)
3-[(4-Methoxybenzyl)oxy]-N-[3-(trifluoromethyl)phenyl]-2-thiophenecarboxamide
CAS 339098-38-3C20H16F3NO3S
![3-[(2,4-Dichlorophenyl)methoxy]-N-(4-nitrophenyl)thiophene-2-carboxamide chemical structure, C18H12Cl2N2O4S, CAS 339098-07-6](/s/DAAKZGYOFPUAJO-UHFFFAOYSA-N.svg)
3-[(2,4-Dichlorophenyl)methoxy]-N-(4-nitrophenyl)thiophene-2-carboxamide
CAS 339098-07-6C18H12Cl2N2O4S
![N-(2,4-Difluorophenyl)-3-{[3-(trifluoromethyl)benzyl]oxy}-2-thiophenecarboxamide chemical structure, C19H12F5NO2S, CAS 344273-05-8](/s/ALPRZNGOCROHID-UHFFFAOYSA-N.svg)
N-(2,4-Difluorophenyl)-3-{[3-(trifluoromethyl)benzyl]oxy}-2-thiophenecarboxamide
CAS 344273-05-8C19H12F5NO2S
![N-(3,4-Dichlorophenyl)-3-[(4-methoxyphenyl)methoxy]thiophene-2-carboxamide chemical structure, C19H15Cl2NO3S, CAS 339098-25-8](/s/HURUJIPEGVVHKP-UHFFFAOYSA-N.svg)
N-(3,4-Dichlorophenyl)-3-[(4-methoxyphenyl)methoxy]thiophene-2-carboxamide
CAS 339098-25-8C19H15Cl2NO3S
![N-[3,5-Bis(trifluoromethyl)phenyl]-3-[(4-methoxyphenyl)methoxy]thiophene-2-carboxamide chemical structure, C21H15F6NO3S, CAS 339098-42-9](/s/BGZTZGBSNLSVRK-UHFFFAOYSA-N.svg)
N-[3,5-Bis(trifluoromethyl)phenyl]-3-[(4-methoxyphenyl)methoxy]thiophene-2-carboxamide
CAS 339098-42-9C21H15F6NO3S
![N-(3,4-Dichlorophenyl)-3-[(2,4-dichlorophenyl)methoxy]thiophene-2-carboxamide chemical structure, C18H11Cl4NO2S, CAS 339098-03-2](/s/SLZDKBRDBFVCEU-UHFFFAOYSA-N.svg)
N-(3,4-Dichlorophenyl)-3-[(2,4-dichlorophenyl)methoxy]thiophene-2-carboxamide
CAS 339098-03-2C18H11Cl4NO2S
![N-(4-Bromophenyl)-3-[(2,4-dichlorophenyl)methoxy]thiophene-2-carboxamide chemical structure, C18H12BrCl2NO2S, CAS 339098-05-4](/s/GHERBXSRRDCITD-UHFFFAOYSA-N.svg)
N-(4-Bromophenyl)-3-[(2,4-dichlorophenyl)methoxy]thiophene-2-carboxamide
CAS 339098-05-4C18H12BrCl2NO2S
![N-(4-Bromophenyl)-3-[(4-tert-butylphenyl)methoxy]thiophene-2-carboxamide chemical structure, C22H22BrNO2S, CAS 344272-78-2](/s/RPDIQRUJDFINAZ-UHFFFAOYSA-N.svg)
N-(4-Bromophenyl)-3-[(4-tert-butylphenyl)methoxy]thiophene-2-carboxamide
CAS 344272-78-2C22H22BrNO2S
![N-[3,5-Bis(trifluoromethyl)phenyl]-3-[(2,4-dichlorophenyl)methoxy]thiophene-2-carboxamide chemical structure, C20H11Cl2F6NO2S, CAS 339098-11-2](/s/AGYYJOPIRDXMEY-UHFFFAOYSA-N.svg)
N-[3,5-Bis(trifluoromethyl)phenyl]-3-[(2,4-dichlorophenyl)methoxy]thiophene-2-carboxamide
CAS 339098-11-2C20H11Cl2F6NO2S
![3-[(2,4-Dichlorophenyl)methoxy]-N-[4-(trifluoromethyl)phenyl]thiophene-2-carboxamide chemical structure, C19H12Cl2F3NO2S, CAS 339098-08-7](/s/WBOXJPWCAFJIFP-UHFFFAOYSA-N.svg)
3-[(2,4-Dichlorophenyl)methoxy]-N-[4-(trifluoromethyl)phenyl]thiophene-2-carboxamide
CAS 339098-08-7C19H12Cl2F3NO2S
![N-[4-Chloro-2-(trifluoromethyl)phenyl]-3-[(2,4-dichlorophenyl)methoxy]thiophene-2-carboxamide chemical structure, C19H11Cl3F3NO2S, CAS 339098-10-1](/s/VRYCXCJQHFNJEJ-UHFFFAOYSA-N.svg)
N-[4-Chloro-2-(trifluoromethyl)phenyl]-3-[(2,4-dichlorophenyl)methoxy]thiophene-2-carboxamide
CAS 339098-10-1C19H11Cl3F3NO2S
![3-[(2,6-Dichlorophenyl)methoxy]-N-(2,4-difluorophenyl)thiophene-2-carboxamide chemical structure, C18H11Cl2F2NO2S, CAS 344269-91-6](/s/KFTXDTPQXUVMLX-UHFFFAOYSA-N.svg)
3-[(2,6-Dichlorophenyl)methoxy]-N-(2,4-difluorophenyl)thiophene-2-carboxamide
CAS 344269-91-6C18H11Cl2F2NO2S
![3-[(4-tert-Butylphenyl)methoxy]-N-(3,4-dichlorophenyl)thiophene-2-carboxamide chemical structure, C22H21Cl2NO2S, CAS 344270-52-6](/s/RLGDVYSIBWKRLB-UHFFFAOYSA-N.svg)
3-[(4-tert-Butylphenyl)methoxy]-N-(3,4-dichlorophenyl)thiophene-2-carboxamide
CAS 344270-52-6C22H21Cl2NO2S
![3-[(4-tert-Butylphenyl)methoxy]-N-(2,4-difluorophenyl)thiophene-2-carboxamide chemical structure, C22H21F2NO2S, CAS 344270-59-3](/s/LPNRWDUZRQLBKU-UHFFFAOYSA-N.svg)
3-[(4-tert-Butylphenyl)methoxy]-N-(2,4-difluorophenyl)thiophene-2-carboxamide
CAS 344270-59-3C22H21F2NO2S
![3-[(2,6-Dichlorophenyl)methoxy]-N-(4-nitrophenyl)thiophene-2-carboxamide chemical structure, C18H12Cl2N2O4S, CAS 344270-35-5](/s/CQWAIELFRQDFBZ-UHFFFAOYSA-N.svg)
3-[(2,6-Dichlorophenyl)methoxy]-N-(4-nitrophenyl)thiophene-2-carboxamide
CAS 344270-35-5C18H12Cl2N2O4S
![3-[(4-tert-Butylphenyl)methoxy]-N-[4-(trifluoromethyl)phenyl]thiophene-2-carboxamide chemical structure, C23H22F3NO2S, CAS 344272-91-9](/s/KIOGEGWFRFVCJQ-UHFFFAOYSA-N.svg)
3-[(4-tert-Butylphenyl)methoxy]-N-[4-(trifluoromethyl)phenyl]thiophene-2-carboxamide
CAS 344272-91-9C23H22F3NO2S
![3-[(4-Methoxyphenyl)methoxy]-N-(4-nitrophenyl)thiophene-2-carboxamide chemical structure, C19H16N2O5S, CAS 339098-27-0](/s/JRJZFWVJHCGMBR-UHFFFAOYSA-N.svg)
3-[(4-Methoxyphenyl)methoxy]-N-(4-nitrophenyl)thiophene-2-carboxamide
CAS 339098-27-0C19H16N2O5S
- 3-[(4-tert-Butylphenyl)methoxy]-N-(4-nitrophenyl)thiophene-2-carboxamide344272-85-1C22H22N2O4S
- N-(3,4-Dichlorophenyl)-3-{[3-(trifluoromethyl)benzyl]oxy}-2-thiophenecarboxamide344272-98-6C19H12Cl2F3NO2S
- 3-[(4-tert-Butylphenyl)methoxy]-N-(3,4-difluorophenyl)thiophene-2-carboxamide344270-65-1C22H21F2NO2S
- N-(4-Bromophenyl)-3-{[3-(trifluoromethyl)benzyl]oxy}-2-thiophenecarboxamide344273-12-7C19H13BrF3NO2S
- N-(3,4-Dichlorophenyl)-3-[(2,6-dichlorophenyl)methoxy]thiophene-2-carboxamide344269-85-8C18H11Cl4NO2S
- 3-[(2,6-Dichlorophenyl)methoxy]-N-(3,4-difluorophenyl)thiophene-2-carboxamide344269-97-2C18H11Cl2F2NO2S
- N-(4-Bromophenyl)-3-[(2,6-dichlorophenyl)methoxy]thiophene-2-carboxamide344270-40-2C18H12BrCl2NO2S
- N-(2,3-Dichlorophenyl)-3-[(2,6-dichlorophenyl)methoxy]thiophene-2-carboxamide344270-16-2C18H11Cl4NO2S
- 3-[(2,6-Dichlorophenyl)methoxy]-N-[4-(trifluoromethyl)phenyl]thiophene-2-carboxamide344270-46-8C19H12Cl2F3NO2S
- 3-[(4-tert-Butylphenyl)methoxy]-N-(2,3-dichlorophenyl)thiophene-2-carboxamide344270-78-6C22H21Cl2NO2S
- 3-[(4-tert-Butylphenyl)methoxy]-N-(2-chlorophenyl)thiophene-2-carboxamide344270-72-0C22H22ClNO2S
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold S=c1[nH]nc(COc2ccccc2)n1N=Cc1ccccc1](/scaffold/WIMFCFWDUQGEKM-UHFFFAOYSA-N/structure.svg)
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O=C(Cc1ccccc1)N1CCN=C1SCc1ccccc110 chemicals![Scaffold O=C(Nc1cn[nH]c1C(=O)NC1CCNCC1)c1ccccc1](/scaffold/KXXAHPWLDUSDRP-UHFFFAOYSA-N/structure.svg)
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O=C(Nc1nonc1NC(=O)c1ccccc1)c1ccccc11 chemical![Scaffold O=C(Nc1ccccc1)c1[nH]ncc1N=Cc1ccccc1](/scaffold/BKQQNESBWNFHKG-UHFFFAOYSA-N/structure.svg)
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