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Murcko scaffold

Ring system with 4 rings and 24 atoms

21 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
21
With full pages
1
Scaffold SMILES

O=C(Nc1ccccc1)c1cnn2c1NC(c1ccccc1)CC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)c1cnn2c1NC(c1ccccc1)CC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 21 of 21 chemicals

rel-(5R,7S)-N-(2,4-Dimethoxyphenyl)-4,5,6,7-tetrahydro-5-(3-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide chemical structure, C23H23F3N4O4, CAS 848436-26-0
rel-(5R,7S)-N-(2,4-Dimethoxyphenyl)-4,5,6,7-tetrahydro-5-(3-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS 848436-26-0C23H23F3N4O4
5-(4-Methoxyphenyl)-N-[2-(methylsulfanyl)phenyl]-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide chemical structure, C22H21F3N4O2S, CAS 332854-29-2
5-(4-Methoxyphenyl)-N-[2-(methylsulfanyl)phenyl]-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS 332854-29-2C22H21F3N4O2S
N-(2,4-Difluorophenyl)-5-(3,4-dimethoxyphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide chemical structure, C22H19F5N4O3, CAS 332854-04-3
N-(2,4-Difluorophenyl)-5-(3,4-dimethoxyphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS 332854-04-3C22H19F5N4O3
5-(4-Bromophenyl)-N-(4-chloro-3-fluorophenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide chemical structure, C20H14BrClF4N4O, CAS 380873-81-4
5-(4-Bromophenyl)-N-(4-chloro-3-fluorophenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS 380873-81-4C20H14BrClF4N4O
N-(2,4-Dimethoxyphenyl)-5-(4-fluorophenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide chemical structure, C22H20F4N4O3, CAS 332853-79-9
N-(2,4-Dimethoxyphenyl)-5-(4-fluorophenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS 332853-79-9C22H20F4N4O3
N-(3,4-Dichlorophenyl)-5-phenyl-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide chemical structure, C20H15Cl2F3N4O, CAS 351438-84-1
N-(3,4-Dichlorophenyl)-5-phenyl-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS 351438-84-1C20H15Cl2F3N4O
5-(4-Methylphenyl)-N-[4-(trifluoromethoxy)phenyl]-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide chemical structure, C22H18F6N4O2, CAS 332858-98-7
5-(4-Methylphenyl)-N-[4-(trifluoromethoxy)phenyl]-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS 332858-98-7C22H18F6N4O2
5-(3,4-Dimethoxyphenyl)-N-[3-(1-hydroxyethyl)phenyl]-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide chemical structure, C24H25F3N4O4, CAS 6074-18-6
5-(3,4-Dimethoxyphenyl)-N-[3-(1-hydroxyethyl)phenyl]-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS 6074-18-6C24H25F3N4O4
N-(3-Chlorophenyl)-5-(4-methylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide chemical structure, C21H18ClF3N4O, CAS 332858-83-0
N-(3-Chlorophenyl)-5-(4-methylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS 332858-83-0C21H18ClF3N4O
5-(4-Bromophenyl)-N-(3,4-dichlorophenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide chemical structure, C20H14BrCl2F3N4O, CAS 351895-05-1
5-(4-Bromophenyl)-N-(3,4-dichlorophenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS 351895-05-1C20H14BrCl2F3N4O
5-(4-Bromophenyl)-7-(trifluoromethyl)-N-(3,4,5-trimethoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide chemical structure, C23H22BrF3N4O4, CAS 381209-54-7
5-(4-Bromophenyl)-7-(trifluoromethyl)-N-(3,4,5-trimethoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS 381209-54-7C23H22BrF3N4O4
Ethyl2-({[5-phenyl-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]carbonyl}amino)benzoate chemical structure, C23H21F3N4O3, CAS 351438-85-2
Ethyl2-({[5-phenyl-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]carbonyl}amino)benzoate
CAS 351438-85-2C23H21F3N4O3
N-(3,4-Dimethoxyphenyl)-5-phenyl-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide chemical structure, C22H21F3N4O3, CAS 332853-61-9
N-(3,4-Dimethoxyphenyl)-5-phenyl-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS 332853-61-9C22H21F3N4O3
N-(5-Chloro-2-hydroxyphenyl)-5-(3,4-dimethoxyphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide chemical structure, C22H20ClF3N4O4, CAS 332853-93-7
N-(5-Chloro-2-hydroxyphenyl)-5-(3,4-dimethoxyphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS 332853-93-7C22H20ClF3N4O4
N,5-bis(3,4-dimethoxyphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide chemical structure, C24H25F3N4O5, CAS 332854-00-9
N,5-bis(3,4-dimethoxyphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS 332854-00-9C24H25F3N4O5
N-[3-(1-Hydroxyethyl)phenyl]-5-phenyl-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide chemical structure, C22H21F3N4O2, CAS 357293-48-2
N-[3-(1-Hydroxyethyl)phenyl]-5-phenyl-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS 357293-48-2C22H21F3N4O2
5-(4-Bromophenyl)-7-(trifluoromethyl)-N-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide chemical structure, C21H15BrF6N4O, CAS 438531-98-7
5-(4-Bromophenyl)-7-(trifluoromethyl)-N-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS 438531-98-7C21H15BrF6N4O
5-(4-Bromophenyl)-N-(2-methoxyphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide chemical structure, C21H18BrF3N4O2, CAS 444904-91-0
5-(4-Bromophenyl)-N-(2-methoxyphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS 444904-91-0C21H18BrF3N4O2
5-(4-Bromophenyl)-N-(4-chlorophenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide chemical structure, C20H15BrClF3N4O, CAS 444904-99-8
5-(4-Bromophenyl)-N-(4-chlorophenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS 444904-99-8C20H15BrClF3N4O
7-(Difluoromethyl)-N-(3-(2,2,3,3-tetrafluoropropoxy)-5-(2,2,2-trifluoroethoxy)phenyl)-5-(p-tolyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide chemical structure, C26H23F9N4O3, CAS 445245-15-8
7-(Difluoromethyl)-N-(3-(2,2,3,3-tetrafluoropropoxy)-5-(2,2,2-trifluoroethoxy)phenyl)-5-(p-tolyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS 445245-15-8C26H23F9N4O3
5-(4-Bromophenyl)-N-(3-methoxy-5-nitrophenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide chemical structure, C21H17BrF3N5O4, CAS 444904-94-3
5-(4-Bromophenyl)-N-(3-methoxy-5-nitrophenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS 444904-94-3C21H17BrF3N5O4