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Murcko scaffold

Ring system with 4 rings and 27 atoms

35 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
27
Chemicals
35
With full pages
9
Scaffold SMILES

O=C(Cn1nc(-c2ccccc2)c2ccccc2c1=O)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Cn1nc(-c2ccccc2)c2ccccc2c1=O)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 35 of 35 chemicals

N-(2-Chlorophenyl)-2-[4-(3-nitrophenyl)-1-oxophthalazin-2-yl]acetamide chemical structure, C22H15ClN4O4, CAS 495377-75-8
N-(2-Chlorophenyl)-2-[4-(3-nitrophenyl)-1-oxophthalazin-2-yl]acetamide
CAS 495377-75-8C22H15ClN4O4
2-(1-Oxo-4-phenylphthalazin-2-yl)-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C23H16F3N3O2, CAS 495381-80-1
2-(1-Oxo-4-phenylphthalazin-2-yl)-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 495381-80-1C23H16F3N3O2
N,N-Diethyl-4-[[2-(1-oxo-4-phenylphthalazin-2-yl)acetyl]amino]benzamide chemical structure, C27H26N4O3, CAS 684234-91-1
N,N-Diethyl-4-[[2-(1-oxo-4-phenylphthalazin-2-yl)acetyl]amino]benzamide
CAS 684234-91-1C27H26N4O3
N,N-Dimethyl-4-[[2-(1-oxo-4-phenylphthalazin-2-yl)acetyl]amino]benzamide chemical structure, C25H22N4O3, CAS 684234-90-0
N,N-Dimethyl-4-[[2-(1-oxo-4-phenylphthalazin-2-yl)acetyl]amino]benzamide
CAS 684234-90-0C25H22N4O3
N-(4-Hydroxyphenyl)-2-(1-oxo-4-phenylphthalazin-2-yl)acetamide chemical structure, C22H17N3O3, CAS 364621-54-5
N-(4-Hydroxyphenyl)-2-(1-oxo-4-phenylphthalazin-2-yl)acetamide
CAS 364621-54-5C22H17N3O3
N-(3-Hydroxyphenyl)-2-(1-oxo-4-phenylphthalazin-2-yl)acetamide chemical structure, C22H17N3O3, CAS 364621-37-4
N-(3-Hydroxyphenyl)-2-(1-oxo-4-phenylphthalazin-2-yl)acetamide
CAS 364621-37-4C22H17N3O3
Methyl 4-({[4-(4-methylphenyl)-1-oxophthalazin-2(1H)-yl]acetyl}amino)benzoate chemical structure, C25H21N3O4, CAS 333742-12-4
Methyl 4-({[4-(4-methylphenyl)-1-oxophthalazin-2(1H)-yl]acetyl}amino)benzoate
CAS 333742-12-4C25H21N3O4
N-(4-Methoxyphenyl)-2-[4-(4-methylphenyl)-1-oxophthalazin-2(1H)-yl]acetamide chemical structure, C24H21N3O3, CAS 333742-13-5
N-(4-Methoxyphenyl)-2-[4-(4-methylphenyl)-1-oxophthalazin-2(1H)-yl]acetamide
CAS 333742-13-5C24H21N3O3
N-(2-Hydroxyphenyl)-2-[4-(4-methylphenyl)-1-oxophthalazin-2(1H)-yl]acetamide chemical structure, C23H19N3O3, CAS 333742-15-7
N-(2-Hydroxyphenyl)-2-[4-(4-methylphenyl)-1-oxophthalazin-2(1H)-yl]acetamide
CAS 333742-15-7C23H19N3O3
2-{4-[3-(Dimethylsulfamoyl)-4-methylphenyl]-1-oxophthalazin-2(1H)-yl}-N-(2-methylphenyl)acetamide chemical structure, C26H26N4O4S, CAS 374921-35-4
2-{4-[3-(Dimethylsulfamoyl)-4-methylphenyl]-1-oxophthalazin-2(1H)-yl}-N-(2-methylphenyl)acetamide
CAS 374921-35-4C26H26N4O4S
2-{4-[3-(Dimethylsulfamoyl)-4-methylphenyl]-1-oxophthalazin-2(1H)-yl}-N-(3-methylphenyl)acetamide chemical structure, C26H26N4O4S, CAS 333755-68-3
2-{4-[3-(Dimethylsulfamoyl)-4-methylphenyl]-1-oxophthalazin-2(1H)-yl}-N-(3-methylphenyl)acetamide
CAS 333755-68-3C26H26N4O4S
2-{4-[3-(Dimethylsulfamoyl)-4-methylphenyl]-1-oxophthalazin-2(1H)-yl}-N-(4-methylphenyl)acetamide chemical structure, C26H26N4O4S, CAS 376371-04-9
2-{4-[3-(Dimethylsulfamoyl)-4-methylphenyl]-1-oxophthalazin-2(1H)-yl}-N-(4-methylphenyl)acetamide
CAS 376371-04-9C26H26N4O4S
2-[4-(4-Methyl-3-nitrophenyl)-1-oxophthalazin-2-yl]-N-(4-methylphenyl)acetamide chemical structure, C24H20N4O4, CAS 444930-74-9
2-[4-(4-Methyl-3-nitrophenyl)-1-oxophthalazin-2-yl]-N-(4-methylphenyl)acetamide
CAS 444930-74-9C24H20N4O4
2-[4-(4-Methylphenyl)-1-oxophthalazin-2-yl]-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C24H18F3N3O2, CAS 664978-35-2
2-[4-(4-Methylphenyl)-1-oxophthalazin-2-yl]-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 664978-35-2C24H18F3N3O2
N-(2-Methoxyphenyl)-2-[4-(3-nitrophenyl)-1-oxophthalazin-2-yl]acetamide chemical structure, C23H18N4O5, CAS 701218-80-6
N-(2-Methoxyphenyl)-2-[4-(3-nitrophenyl)-1-oxophthalazin-2-yl]acetamide
CAS 701218-80-6C23H18N4O5
2-[4-(4-Chlorophenyl)-1-oxophthalazin-2-yl]-N-(3-methylphenyl)acetamide chemical structure, C23H18ClN3O2, CAS 684234-52-4
2-[4-(4-Chlorophenyl)-1-oxophthalazin-2-yl]-N-(3-methylphenyl)acetamide
CAS 684234-52-4C23H18ClN3O2
N-(4-Fluorophenyl)-2-[4-(4-methylphenyl)-1-oxophthalazin-2-yl]acetamide chemical structure, C23H18FN3O2, CAS 684234-85-3
N-(4-Fluorophenyl)-2-[4-(4-methylphenyl)-1-oxophthalazin-2-yl]acetamide
CAS 684234-85-3C23H18FN3O2
2-(4-(4-Chlorophenyl)-1-oxophthalazin-2(1H)-yl)-N-(4-fluorophenyl)acetamide chemical structure, C22H15ClFN3O2, CAS 684234-60-4
2-(4-(4-Chlorophenyl)-1-oxophthalazin-2(1H)-yl)-N-(4-fluorophenyl)acetamide
CAS 684234-60-4C22H15ClFN3O2
2-[4-(4-Chlorophenyl)-1-oxophthalazin-2-yl]-N-(2-methoxyphenyl)acetamide chemical structure, C23H18ClN3O3, CAS 684234-59-1
2-[4-(4-Chlorophenyl)-1-oxophthalazin-2-yl]-N-(2-methoxyphenyl)acetamide
CAS 684234-59-1C23H18ClN3O3
N-(2,4-Dimethylphenyl)-2-[4-[3-(dimethylsulfamoyl)-4-methylphenyl]-1-oxophthalazin-2-yl]acetamide chemical structure, C27H28N4O4S, CAS 374915-47-6
N-(2,4-Dimethylphenyl)-2-[4-[3-(dimethylsulfamoyl)-4-methylphenyl]-1-oxophthalazin-2-yl]acetamide
CAS 374915-47-6C27H28N4O4S
2-[4-[3-(Dimethylsulfamoyl)-4-methylphenyl]-1-oxophthalazin-2-yl]-N-(4-methoxyphenyl)acetamide chemical structure, C26H26N4O5S, CAS 375836-04-7
2-[4-[3-(Dimethylsulfamoyl)-4-methylphenyl]-1-oxophthalazin-2-yl]-N-(4-methoxyphenyl)acetamide
CAS 375836-04-7C26H26N4O5S
N-(2,5-Dimethylphenyl)-2-[4-(4-methylphenyl)-1-oxophthalazin-2-yl]acetamide chemical structure, C25H23N3O2, CAS 364599-93-9
N-(2,5-Dimethylphenyl)-2-[4-(4-methylphenyl)-1-oxophthalazin-2-yl]acetamide
CAS 364599-93-9C25H23N3O2
N-(2-Methylphenyl)-2-[4-(4-methylphenyl)-1-oxophthalazin-2-yl]acetamide chemical structure, C24H21N3O2, CAS 364621-09-0
N-(2-Methylphenyl)-2-[4-(4-methylphenyl)-1-oxophthalazin-2-yl]acetamide
CAS 364621-09-0C24H21N3O2
N-(3-Methylphenyl)-2-[4-(4-methylphenyl)-1-oxophthalazin-2-yl]acetamide chemical structure, C24H21N3O2, CAS 374912-29-5
N-(3-Methylphenyl)-2-[4-(4-methylphenyl)-1-oxophthalazin-2-yl]acetamide
CAS 374912-29-5C24H21N3O2