Free for buyers, contact details stay privateFree for buyers. Your contact details stay private until you accept a quote.

Sign in Join free

Murcko scaffold

Ring system with 5 rings and 33 atoms

29 chemicals on CompoundList share this ring system.

Rings: 5
Scaffold atoms: 33
Chemicals: 29
With full pages: 12

Scaffold SMILES

O=C1C(=Cc2cn(-c3ccccc3)nc2-c2ccccc2)SC(=S)N1CCc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1C(=Cc2cn(-c3ccccc3)nc2-c2ccccc2)SC(=S)N1CCc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 29 of 29 chemicals

(5Z)-5-{[3-(4-Ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C29H25N3O2S2, CAS 313049-79-5

(5Z)-5-{[3-(4-Ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 313049-79-5C₂₉H₂₅N₃O₂S₂

(5Z)-5-({3-[2-Methyl-4-(propan-2-yloxy)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C31H29N3O2S2, CAS 956297-84-0

(5Z)-5-({3-[2-Methyl-4-(propan-2-yloxy)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 956297-84-0C₃₁H₂₉N₃O₂S₂

(5Z)-5-({3-[4-(Ethylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C29H25N3OS3, CAS 1009434-88-1

(5Z)-5-({3-[4-(Ethylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 1009434-88-1C₂₉H₂₅N₃OS₃

(5Z)-3-[2-(3,4-Dimethoxyphenyl)ethyl]-5-[(1,3-diphenyl-1H-pyrazol-4-yl)methylidene]-2-thioxo-1,3-thiazolidin-4-one chemical structure, C29H25N3O3S2, CAS 313362-47-9

(5Z)-3-[2-(3,4-Dimethoxyphenyl)ethyl]-5-[(1,3-diphenyl-1H-pyrazol-4-yl)methylidene]-2-thioxo-1,3-thiazolidin-4-one

CAS 313362-47-9C₂₉H₂₅N₃O₃S₂

(5Z)-5-{[3-(4-Fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C27H20FN3OS2, CAS 313049-90-0

(5Z)-5-{[3-(4-Fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 313049-90-0C₂₇H₂₀FN₃OS₂

5-[[3-(4-Methylphenyl)-1-phenyl-1H-pyrazol-4--yl]methylene]-3-(2-phenylethyl)-2-thioxo-4-thiazolidinone chemical structure, C28H23N3OS2, CAS 313049-95-5

5-[[3-(4-Methylphenyl)-1-phenyl-1H-pyrazol-4--yl]methylene]-3-(2-phenylethyl)-2-thioxo-4-thiazolidinone

CAS 313049-95-5C₂₈H₂₃N₃OS₂

(5Z)-5-{[3-(4-Chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C27H20ClN3OS2, CAS 311810-03-4

(5Z)-5-{[3-(4-Chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 311810-03-4C₂₇H₂₀ClN₃OS₂

(5Z)-5-{[3-(4-Methoxy-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C29H25N3O2S2, CAS 955877-14-2

(5Z)-5-{[3-(4-Methoxy-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 955877-14-2C₂₉H₂₅N₃O₂S₂

(5Z)-5-{[3-(3-Ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C29H25N3O2S2, CAS 1008883-11-1

(5Z)-5-{[3-(3-Ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 1008883-11-1C₂₉H₂₅N₃O₂S₂

(5Z)-5-{[3-(4-Ethoxy-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C30H27N3O2S2, CAS 955875-57-7

(5Z)-5-{[3-(4-Ethoxy-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 955875-57-7C₃₀H₂₇N₃O₂S₂

3-[2-(3,4-Dimethoxyphenyl)ethyl]-5-{[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-methylidene}-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C29H24FN3O3S2, CAS 374598-96-6

3-[2-(3,4-Dimethoxyphenyl)ethyl]-5-{[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-methylidene}-2-sulfanylidene-1,3-thiazolidin-4-one

CAS 374598-96-6C₂₉H₂₄FN₃O₃S₂

(5Z)-3-[2-(3,4-Dimethoxyphenyl)ethyl]-5-{[3-(3-fluoro-4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-2-thioxo-1,3-thiazolidin-4-one chemical structure, C30H26FN3O3S2, CAS 623936-19-6

(5Z)-3-[2-(3,4-Dimethoxyphenyl)ethyl]-5-{[3-(3-fluoro-4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-2-thioxo-1,3-thiazolidin-4-one

CAS 623936-19-6C₃₀H₂₆FN₃O₃S₂

(5Z)-3-(2-Phenylethyl)-5-{[1-phenyl-3-(3-propoxyphenyl)-1H-pyrazol-4-yl]methylidene}-2-thioxo-1,3-thiazolidin-4-one chemical structure, C30H27N3O2S2, CAS 1009437-85-7

(5Z)-3-(2-Phenylethyl)-5-{[1-phenyl-3-(3-propoxyphenyl)-1H-pyrazol-4-yl]methylidene}-2-thioxo-1,3-thiazolidin-4-one

CAS 1009437-85-7C₃₀H₂₇N₃O₂S₂

(5Z)-5-[(1,3-Diphenyl-1H-pyrazol-4-yl)methylene]-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C27H21N3OS2, CAS 624724-46-5

(5Z)-5-[(1,3-Diphenyl-1H-pyrazol-4-yl)methylene]-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 624724-46-5C₂₇H₂₁N₃OS₂

(5Z)-5-{[3-(3-Butoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C31H29N3O2S2, CAS 1008882-59-4

(5Z)-5-{[3-(3-Butoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 1008882-59-4C₃₁H₂₉N₃O₂S₂

(5Z)-5-({3-[2-Methyl-4-(prop-2-en-1-yloxy)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C31H27N3O2S2, CAS 955872-53-4

(5Z)-5-({3-[2-Methyl-4-(prop-2-en-1-yloxy)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 955872-53-4C₃₁H₂₇N₃O₂S₂

(5Z)-3-(2-(3,4-Dimethoxyphenyl)ethyl)-5-((3-(4-isobutoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C33H33N3O4S2, CAS 624724-27-2

(5Z)-3-(2-(3,4-Dimethoxyphenyl)ethyl)-5-((3-(4-isobutoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-2-thioxo-1,3-thiazolidin-4-one

CAS 624724-27-2C₃₃H₃₃N₃O₄S₂

(5Z)-5-{[3-(4-Isobutoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C31H29N3O2S2, CAS 955867-94-4

(5Z)-5-{[3-(4-Isobutoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 955867-94-4C₃₁H₂₉N₃O₂S₂

(5Z)-5-{[3-(3-Chloro-4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C28H22ClN3O2S2, CAS 624724-04-5

(5Z)-5-{[3-(3-Chloro-4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 624724-04-5C₂₈H₂₂ClN₃O₂S₂

(5Z)-3-[2-(3,4-Dimethoxyphenyl)ethyl]-5-{[3-(3-fluoro-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-2-thioxo-1,3-thiazolidin-4-one chemical structure, C32H30FN3O4S2, CAS 623936-36-7

(5Z)-3-[2-(3,4-Dimethoxyphenyl)ethyl]-5-{[3-(3-fluoro-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-2-thioxo-1,3-thiazolidin-4-one

CAS 623936-36-7C₃₂H₃₀FN₃O₄S₂

(5Z)-5-{[3-(4-Ethoxy-3-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-[2-(4-methoxyphenyl)ethyl]-2-thioxo-1,3-thiazolidin-4-one chemical structure, C30H26N4O5S2, CAS 624724-66-9

(5Z)-5-{[3-(4-Ethoxy-3-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-[2-(4-methoxyphenyl)ethyl]-2-thioxo-1,3-thiazolidin-4-one

CAS 624724-66-9C₃₀H₂₆N₄O₅S₂

(5Z)-5-((3-(4-Butoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-3-(2-(4-methoxyphenyl)ethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C32H31N3O3S2, CAS 624724-67-0

(5Z)-5-((3-(4-Butoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-3-(2-(4-methoxyphenyl)ethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 624724-67-0C₃₂H₃₁N₃O₃S₂

(5Z)-5-((3-(3-Fluoro-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C30H26FN3O2S2, CAS 623940-48-7

(5Z)-5-((3-(3-Fluoro-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 623940-48-7C₃₀H₂₆FN₃O₂S₂

(5Z)-5-{[3-(2-Methyl-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C31H29N3O2S2, CAS 955877-62-0

(5Z)-5-{[3-(2-Methyl-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 955877-62-0C₃₁H₂₉N₃O₂S₂