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Murcko scaffold

Ring system with 4 rings and 24 atoms

29 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 24
Chemicals: 29
With full pages: 15

Scaffold SMILES

O=C1NC(=S)SC1=C1C(=O)N(Cc2ccccc2)c2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1NC(=S)SC1=C1C(=O)N(Cc2ccccc2)c2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 29 of 29 chemicals

2-[(5Z)-5-[1-[(4-Fluorophenyl)methyl]-2-oxoindol-3-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid chemical structure, C20H13FN2O4S2, CAS 380904-58-5

2-[(5Z)-5-[1-[(4-Fluorophenyl)methyl]-2-oxoindol-3-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid

CAS 380904-58-5C₂₀H₁₃FN₂O₄S₂

2-[(5Z)-5-(1-Benzyl-5-bromo-2-oxoindol-3-ylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid chemical structure, C20H13BrN2O4S2, CAS 381175-18-4

2-[(5Z)-5-(1-Benzyl-5-bromo-2-oxoindol-3-ylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid

CAS 381175-18-4C₂₀H₁₃BrN₂O₄S₂

3-{4-Oxo-5-[2-oxo-1-benzylbenzo[d]azolidin-3-ylidene]-2-thioxo-1,3-thiazolidin-3-yl}propanoic acid chemical structure, C21H16N2O4S2, CAS 1355339-16-0

3-{4-Oxo-5-[2-oxo-1-benzylbenzo[d]azolidin-3-ylidene]-2-thioxo-1,3-thiazolidin-3-yl}propanoic acid

CAS 1355339-16-0C₂₁H₁₆N₂O₄S₂

3-[(5E)-5-[1-[(2-Chlorophenyl)methyl]-2-oxoindol-3-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid chemical structure, C21H15ClN2O4S2, CAS 6140-41-6

3-[(5E)-5-[1-[(2-Chlorophenyl)methyl]-2-oxoindol-3-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid

CAS 6140-41-6C₂₁H₁₅ClN₂O₄S₂

3-[(5Z)-5-[1-[(4-Fluorophenyl)methyl]-2-oxoindol-3-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid chemical structure, C21H15FN2O4S2, CAS 380560-92-9

3-[(5Z)-5-[1-[(4-Fluorophenyl)methyl]-2-oxoindol-3-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid

CAS 380560-92-9C₂₁H₁₅FN₂O₄S₂

(5Z)-5-(1-Benzyl-5-bromo-2-oxoindol-3-ylidene)-3-(2-methoxyethyl)-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C21H17BrN2O3S2, CAS 380878-78-4

(5Z)-5-(1-Benzyl-5-bromo-2-oxoindol-3-ylidene)-3-(2-methoxyethyl)-2-sulfanylidene-1,3-thiazolidin-4-one

CAS 380878-78-4C₂₁H₁₇BrN₂O₃S₂

2-[(5Z)-5-[1-[(4-Methylphenyl)methyl]-2-oxoindol-3-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid chemical structure, C21H16N2O4S2, CAS 380540-98-7

2-[(5Z)-5-[1-[(4-Methylphenyl)methyl]-2-oxoindol-3-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid

CAS 380540-98-7C₂₁H₁₆N₂O₄S₂

2-[(5Z)-5-[1-[(4-Fluorophenyl)methyl]-2-oxoindol-3-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]ethanesulfonic acid chemical structure, C20H15FN2O5S3, CAS 381194-75-8

2-[(5Z)-5-[1-[(4-Fluorophenyl)methyl]-2-oxoindol-3-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]ethanesulfonic acid

CAS 381194-75-8C₂₀H₁₅FN₂O₅S₃

(5Z)-5-[1-[(4-Methylphenyl)methyl]-2-oxoindol-3-ylidene]-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C22H18N2O2S2, CAS 381696-54-4

(5Z)-5-[1-[(4-Methylphenyl)methyl]-2-oxoindol-3-ylidene]-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-4-one

CAS 381696-54-4C₂₂H₁₈N₂O₂S₂

2-[(5Z)-5-[1-[(4-Methylphenyl)methyl]-2-oxoindol-3-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]ethanesulfonic acid chemical structure, C21H18N2O5S3, CAS 380904-53-0

2-[(5Z)-5-[1-[(4-Methylphenyl)methyl]-2-oxoindol-3-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]ethanesulfonic acid

CAS 380904-53-0C₂₁H₁₈N₂O₅S₃

(3Z)-1-(4-Methylbenzyl)-3-(4-oxo-3-propyl-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one chemical structure, C22H20N2O2S2, CAS 609795-05-3

(3Z)-1-(4-Methylbenzyl)-3-(4-oxo-3-propyl-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one

CAS 609795-05-3C₂₂H₂₀N₂O₂S₂

(3Z)-3-[3-(3-Ethoxypropyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1-(4-methylbenzyl)-1,3-dihydro-2H-indol-2-one chemical structure, C24H24N2O3S2, CAS 609795-11-1

(3Z)-3-[3-(3-Ethoxypropyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1-(4-methylbenzyl)-1,3-dihydro-2H-indol-2-one

CAS 609795-11-1C₂₄H₂₄N₂O₃S₂

4-((5Z)-5-(1-(4-Methylbenzyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)butanoic acid chemical structure, C23H20N2O4S2, CAS 617694-93-6

4-((5Z)-5-(1-(4-Methylbenzyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)butanoic acid

CAS 617694-93-6C₂₃H₂₀N₂O₄S₂

(3Z)-3-[3-(2-Methoxyethyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1-(4-methylbenzyl)-1,3-dihydro-2H-indol-2-one chemical structure, C22H20N2O3S2, CAS 617694-99-2

(3Z)-3-[3-(2-Methoxyethyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1-(4-methylbenzyl)-1,3-dihydro-2H-indol-2-one

CAS 617694-99-2C₂₂H₂₀N₂O₃S₂

(3Z)-3-[3-(3-Methoxypropyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1-(4-methylbenzyl)-1,3-dihydro-2H-indol-2-one chemical structure, C23H22N2O3S2, CAS 617695-01-9

(3Z)-3-[3-(3-Methoxypropyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1-(4-methylbenzyl)-1,3-dihydro-2H-indol-2-one

CAS 617695-01-9C₂₃H₂₂N₂O₃S₂

(Z)-5-(1-(2-Fluorobenzyl)-2-oxoindolin-3-ylidene)-3-(3-methoxypropyl)-2-thioxothiazolidin-4-one chemical structure, C22H19FN2O3S2, CAS 865593-43-7

(Z)-5-(1-(2-Fluorobenzyl)-2-oxoindolin-3-ylidene)-3-(3-methoxypropyl)-2-thioxothiazolidin-4-one

CAS 865593-43-7C₂₂H₁₉FN₂O₃S₂

(5Z)-5-(1-Benzyl-2-oxoindol-3-ylidene)-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C21H16N2O2S2, CAS 692769-58-7

(5Z)-5-(1-Benzyl-2-oxoindol-3-ylidene)-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-4-one

CAS 692769-58-7C₂₁H₁₆N₂O₂S₂

6-(5-{1-[(2-Chlorophenyl)methyl]-2-oxo-1,2-dihydro-3H-indol-3-ylidene}-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)hexanoic acid chemical structure, C24H21ClN2O4S2, CAS 6613-84-9

6-(5-{1-[(2-Chlorophenyl)methyl]-2-oxo-1,2-dihydro-3H-indol-3-ylidene}-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)hexanoic acid

CAS 6613-84-9C₂₄H₂₁ClN₂O₄S₂

(3Z)-1-(4-Methylbenzyl)-3-(3-octyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one chemical structure, C27H30N2O2S2, CAS 617696-17-0

(3Z)-1-(4-Methylbenzyl)-3-(3-octyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one

CAS 617696-17-0C₂₇H₃₀N₂O₂S₂

(3Z)-3-(3-Heptyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1-(4-methylbenzyl)-1,3-dihydro-2H-indol-2-one chemical structure, C26H28N2O2S2, CAS 609795-09-7

(3Z)-3-(3-Heptyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1-(4-methylbenzyl)-1,3-dihydro-2H-indol-2-one

CAS 609795-09-7C₂₆H₂₈N₂O₂S₂

(3Z)-3-(3-Butyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1-(4-methylbenzyl)-1,3-dihydro-2H-indol-2-one chemical structure, C23H22N2O2S2, CAS 609795-19-9

(3Z)-3-(3-Butyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1-(4-methylbenzyl)-1,3-dihydro-2H-indol-2-one

CAS 609795-19-9C₂₃H₂₂N₂O₂S₂

(3Z)-3-(3-sec-Butyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1-(4-methylbenzyl)-1,3-dihydro-2H-indol-2-one chemical structure, C23H22N2O2S2, CAS 617695-04-2

(3Z)-3-(3-sec-Butyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1-(4-methylbenzyl)-1,3-dihydro-2H-indol-2-one

CAS 617695-04-2C₂₃H₂₂N₂O₂S₂

(3Z)-3-[3-(2-Ethylhexyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1-(4-methylbenzyl)-1,3-dihydro-2H-indol-2-one chemical structure, C27H30N2O2S2, CAS 617695-03-1

(3Z)-3-[3-(2-Ethylhexyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1-(4-methylbenzyl)-1,3-dihydro-2H-indol-2-one

CAS 617695-03-1C₂₇H₃₀N₂O₂S₂

(3Z)-3-(3-Isopropyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1-(4-methylbenzyl)-1,3-dihydro-2H-indol-2-one chemical structure, C22H20N2O2S2, CAS 617694-92-5

(3Z)-3-(3-Isopropyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1-(4-methylbenzyl)-1,3-dihydro-2H-indol-2-one

CAS 617694-92-5C₂₂H₂₀N₂O₂S₂