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Murcko scaffold

8-Benzoyl-10-phenyl-11A,11B-dihydro-8H-pyrrolo(3',4':3,4)pyrrolo(2,1-A)phthalazine-9,11(8AH,10H)-dione scaffold

20 chemicals on CompoundList share this ring system.

Rings
6
Scaffold atoms
32
Chemicals
20
With full pages
7
Scaffold SMILES

O=C(c1ccccc1)C1C2C(=O)N(c3ccccc3)C(=O)C2C2c3ccccc3C=NN12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 8-Benzoyl-10-phenyl-11A,11B-dihydro-8H-pyrrolo(3',4':3,4)pyrrolo(2,1-A)phthalazine-9,11(8AH,10H)-dione page
Murcko scaffold O=C(c1ccccc1)C1C2C(=O)N(c3ccccc3)C(=O)C2C2c3ccccc3C=NN12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 20 of 20 chemicals

8-Benzoyl-10-phenyl-11A,11B-dihydro-8H-pyrrolo(3',4':3,4)pyrrolo(2,1-A)phthalazine-9,11(8AH,10H)-dione chemical structure, C26H19N3O3, CAS 853330-06-0
8-Benzoyl-10-phenyl-11A,11B-dihydro-8H-pyrrolo(3',4':3,4)pyrrolo(2,1-A)phthalazine-9,11(8AH,10H)-dione
CAS 853330-06-0C26H19N3O3
8-(4-Fluorobenzoyl)-10-phenyl-11A,11B-dihydro-8H-pyrrolo(3',4':3,4)pyrrolo(2,1-A)phthalazine-9,11(8AH,10H)-dione chemical structure, C26H18FN3O3, CAS 853330-12-8
8-(4-Fluorobenzoyl)-10-phenyl-11A,11B-dihydro-8H-pyrrolo(3',4':3,4)pyrrolo(2,1-A)phthalazine-9,11(8AH,10H)-dione
CAS 853330-12-8C26H18FN3O3
(1S,11S,12R,16S)-14-(4-Acetylphenyl)-11-benzoyl-9,10,14-triazatetracyclo[8.6.0.02,7.012,16]hexadeca-2,4,6,8-tetraene-13,15-dione chemical structure, C28H21N3O4, CAS 1014060-79-7
(1S,11S,12R,16S)-14-(4-Acetylphenyl)-11-benzoyl-9,10,14-triazatetracyclo[8.6.0.02,7.012,16]hexadeca-2,4,6,8-tetraene-13,15-dione
CAS 1014060-79-7C28H21N3O4
(11S,12R,16S)-11-(4-Chlorobenzoyl)-14-(4-nitrophenyl)-9,10,14-triazatetracyclo[8.6.0.02,7.012,16]hexadeca-2,4,6,8-tetraene-13,15-dione chemical structure, C26H17ClN4O5, CAS 1014080-07-9
(11S,12R,16S)-11-(4-Chlorobenzoyl)-14-(4-nitrophenyl)-9,10,14-triazatetracyclo[8.6.0.02,7.012,16]hexadeca-2,4,6,8-tetraene-13,15-dione
CAS 1014080-07-9C26H17ClN4O5
(11S,12R,16S)-11-(4-Chlorobenzoyl)-14-(4-methoxyphenyl)-9,10,14-triazatetracyclo[8.6.0.02,7.012,16]hexadeca-2,4,6,8-tetraene-13,15-dione chemical structure, C27H20ClN3O4, CAS 1014080-16-0
(11S,12R,16S)-11-(4-Chlorobenzoyl)-14-(4-methoxyphenyl)-9,10,14-triazatetracyclo[8.6.0.02,7.012,16]hexadeca-2,4,6,8-tetraene-13,15-dione
CAS 1014080-16-0C27H20ClN3O4
(11S,12R,16S)-11-Benzoyl-14-(2-chlorophenyl)-9,10,14-triazatetracyclo[8.6.0.02,7.012,16]hexadeca-2,4,6,8-tetraene-13,15-dione chemical structure, C26H18ClN3O3, CAS 1014083-28-3
(11S,12R,16S)-11-Benzoyl-14-(2-chlorophenyl)-9,10,14-triazatetracyclo[8.6.0.02,7.012,16]hexadeca-2,4,6,8-tetraene-13,15-dione
CAS 1014083-28-3C26H18ClN3O3
(8S,8aR,11aS)-8-(4-Chlorobenzoyl)-10-(2-methoxy-5-nitrophenyl)-11a,11b-dihydro-8H-pyrrolo[3',4':3,4]pyrrolo[2,1-a]phthalazine-9,11(8aH,10H)-dione chemical structure, C27H19ClN4O6, CAS 1014102-65-8
(8S,8aR,11aS)-8-(4-Chlorobenzoyl)-10-(2-methoxy-5-nitrophenyl)-11a,11b-dihydro-8H-pyrrolo[3',4':3,4]pyrrolo[2,1-a]phthalazine-9,11(8aH,10H)-dione
CAS 1014102-65-8C27H19ClN4O6
(8R,8aS,11aR)-8-(4-Methoxybenzoyl)-10-(2-(trifluoromethyl)phenyl)-11a,11b-dihydro-8H-pyrrolo[3',4':3,4]pyrrolo[2,1-a]phthalazine-9,11(8aH,10H)-dione chemical structure, C28H20F3N3O4, CAS 1014101-89-3
(8R,8aS,11aR)-8-(4-Methoxybenzoyl)-10-(2-(trifluoromethyl)phenyl)-11a,11b-dihydro-8H-pyrrolo[3',4':3,4]pyrrolo[2,1-a]phthalazine-9,11(8aH,10H)-dione
CAS 1014101-89-3C28H20F3N3O4
(11R,12S,16R)-14-(2,4-Dichlorophenyl)-11-(4-methoxybenzoyl)-9,10,14-triazatetracyclo[8.6.0.02,7.012,16]hexadeca-2,4,6,8-tetraene-13,15-dione chemical structure, C27H19Cl2N3O4, CAS 1014060-81-1
(11R,12S,16R)-14-(2,4-Dichlorophenyl)-11-(4-methoxybenzoyl)-9,10,14-triazatetracyclo[8.6.0.02,7.012,16]hexadeca-2,4,6,8-tetraene-13,15-dione
CAS 1014060-81-1C27H19Cl2N3O4
(11R,12S,16R)-11-(4-Fluorobenzoyl)-14-(2-methyl-5-nitrophenyl)-9,10,14-triazatetracyclo[8.6.0.02,7.012,16]hexadeca-2,4,6,8-tetraene-13,15-dione chemical structure, C27H19FN4O5, CAS 1013749-82-0
(11R,12S,16R)-11-(4-Fluorobenzoyl)-14-(2-methyl-5-nitrophenyl)-9,10,14-triazatetracyclo[8.6.0.02,7.012,16]hexadeca-2,4,6,8-tetraene-13,15-dione
CAS 1013749-82-0C27H19FN4O5
(8R,8aS,11aR)-10-(3-Bromophenyl)-8-(4-fluorobenzoyl)-11a,11b-dihydro-8H-pyrrolo[3',4':3,4]pyrrolo[2,1-a]phthalazine-9,11(8aH,10H)-dione chemical structure, C26H17BrFN3O3, CAS 1013803-89-8
(8R,8aS,11aR)-10-(3-Bromophenyl)-8-(4-fluorobenzoyl)-11a,11b-dihydro-8H-pyrrolo[3',4':3,4]pyrrolo[2,1-a]phthalazine-9,11(8aH,10H)-dione
CAS 1013803-89-8C26H17BrFN3O3
(8R,8aS,11aR)-10-(3-Chloro-4-fluorophenyl)-8-(4-fluorobenzoyl)-11a,11b-dihydro-8H-pyrrolo[3',4':3,4]pyrrolo[2,1-a]phthalazine-9,11(8aH,10H)-dione chemical structure, C26H16ClF2N3O3, CAS 1013981-66-2
(8R,8aS,11aR)-10-(3-Chloro-4-fluorophenyl)-8-(4-fluorobenzoyl)-11a,11b-dihydro-8H-pyrrolo[3',4':3,4]pyrrolo[2,1-a]phthalazine-9,11(8aH,10H)-dione
CAS 1013981-66-2C26H16ClF2N3O3
Methyl 2-((8R,8aS,11aR)-8-(4-fluorobenzoyl)-9,11-dioxo-8a,9,11,11a-tetrahydro-8H-pyrrolo[3',4':3,4]pyrrolo[2,1-a]phthalazin-10(11bH)-yl)benzoate chemical structure, C28H20FN3O5, CAS 1013981-80-0
Methyl 2-((8R,8aS,11aR)-8-(4-fluorobenzoyl)-9,11-dioxo-8a,9,11,11a-tetrahydro-8H-pyrrolo[3',4':3,4]pyrrolo[2,1-a]phthalazin-10(11bH)-yl)benzoate
CAS 1013981-80-0C28H20FN3O5
(11R,12S,16R)-11-Benzoyl-14-[4-chloro-3-(trifluoromethyl)phenyl]-9,10,14-triazatetracyclo[8.6.0.02,7.012,16]hexadeca-2,4,6,8-tetraene-13,15-dione chemical structure, C27H17ClF3N3O3, CAS 1013836-33-3
(11R,12S,16R)-11-Benzoyl-14-[4-chloro-3-(trifluoromethyl)phenyl]-9,10,14-triazatetracyclo[8.6.0.02,7.012,16]hexadeca-2,4,6,8-tetraene-13,15-dione
CAS 1013836-33-3C27H17ClF3N3O3
(11R,12S,16R)-11-(4-Fluorobenzoyl)-14-(3-nitrophenyl)-9,10,14-triazatetracyclo[8.6.0.02,7.012,16]hexadeca-2,4,6,8-tetraene-13,15-dione chemical structure, C26H17FN4O5, CAS 1013869-87-8
(11R,12S,16R)-11-(4-Fluorobenzoyl)-14-(3-nitrophenyl)-9,10,14-triazatetracyclo[8.6.0.02,7.012,16]hexadeca-2,4,6,8-tetraene-13,15-dione
CAS 1013869-87-8C26H17FN4O5
8-(4-Nitrobenzoyl)-10-phenyl-11A,11B-dihydro-8H-pyrrolo(3',4':3,4)pyrrolo(2,1-A)phthalazine-9,11(8AH,10H)-dione chemical structure, C26H18N4O5, CAS 83976-27-6
8-(4-Nitrobenzoyl)-10-phenyl-11A,11B-dihydro-8H-pyrrolo(3',4':3,4)pyrrolo(2,1-A)phthalazine-9,11(8AH,10H)-dione
CAS 83976-27-6C26H18N4O5
8-(3-Nitrobenzoyl)-10-phenyl-11A,11B-dihydro-8H-pyrrolo(3',4':3,4)pyrrolo(2,1-A)phthalazine-9,11(8AH,10H)-dione chemical structure, C26H18N4O5, CAS 853330-03-7
8-(3-Nitrobenzoyl)-10-phenyl-11A,11B-dihydro-8H-pyrrolo(3',4':3,4)pyrrolo(2,1-A)phthalazine-9,11(8AH,10H)-dione
CAS 853330-03-7C26H18N4O5
8-Benzoyl-8-methyl-10-phenyl-11A,11B-dihydro-8H-pyrrolo(3',4':3,4)pyrrolo(2,1-A)phthalazine-9,11(8AH,10H)-dione chemical structure, C27H21N3O3, CAS 853333-93-4
8-Benzoyl-8-methyl-10-phenyl-11A,11B-dihydro-8H-pyrrolo(3',4':3,4)pyrrolo(2,1-A)phthalazine-9,11(8AH,10H)-dione
CAS 853333-93-4C27H21N3O3
8-(4-Methylbenzoyl)-10-phenyl-11A,11B-dihydro-8H-pyrrolo(3',4':3,4)pyrrolo(2,1-A)phthalazine-9,11(8AH,10H)-dione chemical structure, C27H21N3O3, CAS 853334-24-4
8-(4-Methylbenzoyl)-10-phenyl-11A,11B-dihydro-8H-pyrrolo(3',4':3,4)pyrrolo(2,1-A)phthalazine-9,11(8AH,10H)-dione
CAS 853334-24-4C27H21N3O3
8-(2-Chlorobenzoyl)-10-phenyl-11A,11B-dihydro-8H-pyrrolo(3',4':3,4)pyrrolo(2,1-A)phthalazine-9,11(8AH,10H)-dione chemical structure, C26H18ClN3O3, CAS 882865-66-9
8-(2-Chlorobenzoyl)-10-phenyl-11A,11B-dihydro-8H-pyrrolo(3',4':3,4)pyrrolo(2,1-A)phthalazine-9,11(8AH,10H)-dione
CAS 882865-66-9C26H18ClN3O3