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Murcko scaffold

N-Benzyl-2-[(3-oxo-4-phenyl-3,4-dihydropyrazin-2-yl)sulfanyl]acetamide scaffold

46 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
25
Chemicals
46
With full pages
6
Scaffold SMILES

O=C(CSc1nccn(-c2ccccc2)c1=O)NCc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the N-Benzyl-2-[(3-oxo-4-phenyl-3,4-dihydropyrazin-2-yl)sulfanyl]acetamide page
Murcko scaffold O=C(CSc1nccn(-c2ccccc2)c1=O)NCc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 46 of 46 chemicals

N-[(2-Chlorophenyl)methyl]-2-[4-(3,5-dimethylphenyl)-3-oxopyrazin-2-yl]sulfanylacetamide chemical structure, C21H20ClN3O2S, CAS 895107-75-2
N-[(2-Chlorophenyl)methyl]-2-[4-(3,5-dimethylphenyl)-3-oxopyrazin-2-yl]sulfanylacetamide
CAS 895107-75-2C21H20ClN3O2S
N-[(2-Chlorophenyl)methyl]-2-[4-(4-methoxyphenyl)-3-oxopyrazin-2-yl]sulfanylacetamide chemical structure, C20H18ClN3O3S, CAS 895111-15-6
N-[(2-Chlorophenyl)methyl]-2-[4-(4-methoxyphenyl)-3-oxopyrazin-2-yl]sulfanylacetamide
CAS 895111-15-6C20H18ClN3O3S
N-Benzyl-2-[4-(3-chloro-4-fluorophenyl)-3-oxopyrazin-2-yl]sulfanylacetamide chemical structure, C19H15ClFN3O2S, CAS 899743-93-2
N-Benzyl-2-[4-(3-chloro-4-fluorophenyl)-3-oxopyrazin-2-yl]sulfanylacetamide
CAS 899743-93-2C19H15ClFN3O2S
N-Benzyl-2-[4-(3-chloro-4-methoxyphenyl)-3-oxopyrazin-2-yl]sulfanylacetamide chemical structure, C20H18ClN3O3S, CAS 899744-20-8
N-Benzyl-2-[4-(3-chloro-4-methoxyphenyl)-3-oxopyrazin-2-yl]sulfanylacetamide
CAS 899744-20-8C20H18ClN3O3S
2-[4-(3-Chloro-4-methylphenyl)-3-oxopyrazin-2-yl]sulfanyl-N-[(4-methylphenyl)methyl]acetamide chemical structure, C21H20ClN3O2S, CAS 899758-93-1
2-[4-(3-Chloro-4-methylphenyl)-3-oxopyrazin-2-yl]sulfanyl-N-[(4-methylphenyl)methyl]acetamide
CAS 899758-93-1C21H20ClN3O2S
N-Benzyl-2-[4-(3-fluoro-4-methylphenyl)-3-oxopyrazin-2-yl]sulfanylacetamide chemical structure, C20H18FN3O2S, CAS 899944-52-6
N-Benzyl-2-[4-(3-fluoro-4-methylphenyl)-3-oxopyrazin-2-yl]sulfanylacetamide
CAS 899944-52-6C20H18FN3O2S
2-[4-(3-Fluoro-4-methylphenyl)-3-oxopyrazin-2-yl]sulfanyl-N-[(4-methylphenyl)methyl]acetamide chemical structure, C21H20FN3O2S, CAS 899759-20-7
2-[4-(3-Fluoro-4-methylphenyl)-3-oxopyrazin-2-yl]sulfanyl-N-[(4-methylphenyl)methyl]acetamide
CAS 899759-20-7C21H20FN3O2S
N-Benzyl-2-[4-(2-methoxyphenyl)-3-oxopyrazin-2-yl]sulfanylacetamide chemical structure, C20H19N3O3S, CAS 899759-29-6
N-Benzyl-2-[4-(2-methoxyphenyl)-3-oxopyrazin-2-yl]sulfanylacetamide
CAS 899759-29-6C20H19N3O3S
2-[4-(2-Methoxyphenyl)-3-oxopyrazin-2-yl]sulfanyl-N-[(4-methylphenyl)methyl]acetamide chemical structure, C21H21N3O3S, CAS 900007-09-2
2-[4-(2-Methoxyphenyl)-3-oxopyrazin-2-yl]sulfanyl-N-[(4-methylphenyl)methyl]acetamide
CAS 900007-09-2C21H21N3O3S
N-Benzyl-2-[4-(4-ethoxyphenyl)-3-oxopyrazin-2-yl]sulfanylacetamide chemical structure, C21H21N3O3S, CAS 900007-21-8
N-Benzyl-2-[4-(4-ethoxyphenyl)-3-oxopyrazin-2-yl]sulfanylacetamide
CAS 900007-21-8C21H21N3O3S
2-[4-(4-Ethoxyphenyl)-3-oxopyrazin-2-yl]sulfanyl-N-[(4-methylphenyl)methyl]acetamide chemical structure, C22H23N3O3S, CAS 900007-32-1
2-[4-(4-Ethoxyphenyl)-3-oxopyrazin-2-yl]sulfanyl-N-[(4-methylphenyl)methyl]acetamide
CAS 900007-32-1C22H23N3O3S
2-[4-(4-Ethoxyphenyl)-3-oxopyrazin-2-yl]sulfanyl-N-[(4-fluorophenyl)methyl]acetamide chemical structure, C21H20FN3O3S, CAS 899759-56-9
2-[4-(4-Ethoxyphenyl)-3-oxopyrazin-2-yl]sulfanyl-N-[(4-fluorophenyl)methyl]acetamide
CAS 899759-56-9C21H20FN3O3S
N-Benzyl-2-[4-(3,4-difluorophenyl)-3-oxopyrazin-2-yl]sulfanylacetamide chemical structure, C19H15F2N3O2S, CAS 899759-72-9
N-Benzyl-2-[4-(3,4-difluorophenyl)-3-oxopyrazin-2-yl]sulfanylacetamide
CAS 899759-72-9C19H15F2N3O2S
2-[4-(3,4-Difluorophenyl)-3-oxopyrazin-2-yl]sulfanyl-N-[(4-methylphenyl)methyl]acetamide chemical structure, C20H17F2N3O2S, CAS 900007-93-4
2-[4-(3,4-Difluorophenyl)-3-oxopyrazin-2-yl]sulfanyl-N-[(4-methylphenyl)methyl]acetamide
CAS 900007-93-4C20H17F2N3O2S
2-[4-(3,4-Difluorophenyl)-3-oxopyrazin-2-yl]sulfanyl-N-[(4-fluorophenyl)methyl]acetamide chemical structure, C19H14F3N3O2S, CAS 900008-07-3
2-[4-(3,4-Difluorophenyl)-3-oxopyrazin-2-yl]sulfanyl-N-[(4-fluorophenyl)methyl]acetamide
CAS 900008-07-3C19H14F3N3O2S
2-[4-(4-Fluorophenyl)-3-oxopyrazin-2-yl]sulfanyl-N-[(4-methylphenyl)methyl]acetamide chemical structure, C20H18FN3O2S, CAS 942034-28-8
2-[4-(4-Fluorophenyl)-3-oxopyrazin-2-yl]sulfanyl-N-[(4-methylphenyl)methyl]acetamide
CAS 942034-28-8C20H18FN3O2S
2-[4-(3,4-Dimethylphenyl)-3-oxopyrazin-2-yl]sulfanyl-N-[(4-methylphenyl)methyl]acetamide chemical structure, C22H23N3O2S, CAS 941970-91-8
2-[4-(3,4-Dimethylphenyl)-3-oxopyrazin-2-yl]sulfanyl-N-[(4-methylphenyl)methyl]acetamide
CAS 941970-91-8C22H23N3O2S
N-Benzyl-2-{[4-(3-fluorophenyl)-3-oxo-3,4-dihydropyrazin-2-yl]sulfanyl}acetamide chemical structure, C19H16FN3O2S, CAS 942034-39-1
N-Benzyl-2-{[4-(3-fluorophenyl)-3-oxo-3,4-dihydropyrazin-2-yl]sulfanyl}acetamide
CAS 942034-39-1C19H16FN3O2S
2-((4-(3-Chloro-4-methoxyphenyl)-3-oxo-3,4-dihydropyrazin-2-yl)thio)-N-(4-methylbenzyl)acetamide chemical structure, C21H20ClN3O3S, CAS 899987-87-2
2-((4-(3-Chloro-4-methoxyphenyl)-3-oxo-3,4-dihydropyrazin-2-yl)thio)-N-(4-methylbenzyl)acetamide
CAS 899987-87-2C21H20ClN3O3S
N-Benzyl-2-((4-(3,4-dimethoxyphenyl)-3-oxo-3,4-dihydropyrazin-2-yl)thio)acetamide chemical structure, C21H21N3O4S, CAS 899987-49-6
N-Benzyl-2-((4-(3,4-dimethoxyphenyl)-3-oxo-3,4-dihydropyrazin-2-yl)thio)acetamide
CAS 899987-49-6C21H21N3O4S
2-((4-(3-Chloro-4-methoxyphenyl)-3-oxo-3,4-dihydropyrazin-2-yl)thio)-N-(4-methoxybenzyl)acetamide chemical structure, C21H20ClN3O4S, CAS 899944-27-5
2-((4-(3-Chloro-4-methoxyphenyl)-3-oxo-3,4-dihydropyrazin-2-yl)thio)-N-(4-methoxybenzyl)acetamide
CAS 899944-27-5C21H20ClN3O4S
N-Benzyl-2-((3-oxo-4-(p-tolyl)-3,4-dihydropyrazin-2-yl)thio)acetamide chemical structure, C20H19N3O2S, CAS 941888-02-4
N-Benzyl-2-((3-oxo-4-(p-tolyl)-3,4-dihydropyrazin-2-yl)thio)acetamide
CAS 941888-02-4C20H19N3O2S
N-(2-Chlorobenzyl)-2-((3-oxo-4-(p-tolyl)-3,4-dihydropyrazin-2-yl)thio)acetamide chemical structure, C20H18ClN3O2S, CAS 941978-16-1
N-(2-Chlorobenzyl)-2-((3-oxo-4-(p-tolyl)-3,4-dihydropyrazin-2-yl)thio)acetamide
CAS 941978-16-1C20H18ClN3O2S
2-((4-(3-Chloro-4-fluorophenyl)-3-oxo-3,4-dihydropyrazin-2-yl)thio)-N-(2-chlorobenzyl)acetamide chemical structure, C19H14Cl2FN3O2S, CAS 899743-96-5
2-((4-(3-Chloro-4-fluorophenyl)-3-oxo-3,4-dihydropyrazin-2-yl)thio)-N-(2-chlorobenzyl)acetamide
CAS 899743-96-5C19H14Cl2FN3O2S