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Murcko scaffold

2-(1-Piperazinyl)-4H-pyrido(1,2-a)pyrimidin-4-one scaffold

18 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
17
Chemicals
18
With full pages
9
Scaffold SMILES

O=c1cc(N2CCNCC2)nc2ccccn12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-(1-Piperazinyl)-4H-pyrido(1,2-a)pyrimidin-4-one page
Murcko scaffold O=c1cc(N2CCNCC2)nc2ccccn12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

2-(1-Piperazinyl)-4H-pyrido(1,2-a)pyrimidin-4-one chemical structure, C12H14N4O, CAS 168425-51-2
2-(1-Piperazinyl)-4H-pyrido(1,2-a)pyrimidin-4-one
CAS 168425-51-2C12H14N4O
2-[4-(2-Hydroxyethyl)piperazin-1-yl]-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde chemical structure, C15H18N4O3, CAS 433255-97-1
2-[4-(2-Hydroxyethyl)piperazin-1-yl]-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde
CAS 433255-97-1C15H18N4O3
2-(4-Methylpiperazin-1-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde chemical structure, C14H16N4O2, CAS 154816-49-6
2-(4-Methylpiperazin-1-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde
CAS 154816-49-6C14H16N4O2
2-(4-Ethylpiperazin-1-yl)-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde chemical structure, C16H20N4O2, CAS 538339-61-6
2-(4-Ethylpiperazin-1-yl)-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde
CAS 538339-61-6C16H20N4O2
9-Methyl-2-(4-methylpiperazin-1-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde chemical structure, C15H18N4O2, CAS 608119-96-6
9-Methyl-2-(4-methylpiperazin-1-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde
CAS 608119-96-6C15H18N4O2
2-[[2-(4-Ethylpiperazin-1-yl)-9-methyl-4-oxopyrido[1,2-a]pyrimidin-3-yl]methylidene]propanedinitrile chemical structure, C19H20N6O, CAS 796880-86-9
2-[[2-(4-Ethylpiperazin-1-yl)-9-methyl-4-oxopyrido[1,2-a]pyrimidin-3-yl]methylidene]propanedinitrile
CAS 796880-86-9C19H20N6O
Ethyl 4-(3-formyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)-1-piperazinecarboxylate chemical structure, C16H18N4O4, CAS 636989-81-6
Ethyl 4-(3-formyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)-1-piperazinecarboxylate
CAS 636989-81-6C16H18N4O4
Ethyl 4-(3-formyl-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)piperazine-1-carboxylate chemical structure, C17H20N4O4, CAS 850159-68-1
Ethyl 4-(3-formyl-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)piperazine-1-carboxylate
CAS 850159-68-1C17H20N4O4
2-[[2-(4-Methylpiperazin-1-yl)-4-oxopyrido[1,2-a]pyrimidin-3-yl]methylidene]propanedinitrile chemical structure, C17H16N6O, CAS 850731-92-9
2-[[2-(4-Methylpiperazin-1-yl)-4-oxopyrido[1,2-a]pyrimidin-3-yl]methylidene]propanedinitrile
CAS 850731-92-9C17H16N6O
2-(4-Ethylpiperazin-1-yl)pyrido[1,2-a]pyrimidin-4-one chemical structure, C14H18N4O, CAS 521283-09-0
2-(4-Ethylpiperazin-1-yl)pyrido[1,2-a]pyrimidin-4-one
CAS 521283-09-0C14H18N4O
2-(4-Ethylpiperazin-1-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde chemical structure, C15H18N4O2, CAS 446830-03-1
2-(4-Ethylpiperazin-1-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde
CAS 446830-03-1C15H18N4O2
7-Methyl-2-(4-methylpiperazin-1-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde chemical structure, C15H18N4O2, CAS 487020-08-6
7-Methyl-2-(4-methylpiperazin-1-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde
CAS 487020-08-6C15H18N4O2
2-(4-Ethylpiperazin-1-yl)-7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde chemical structure, C16H20N4O2, CAS 889996-84-3
2-(4-Ethylpiperazin-1-yl)-7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde
CAS 889996-84-3C16H20N4O2
2-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde chemical structure, C16H20N4O3, CAS 849913-68-4
2-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde
CAS 849913-68-4C16H20N4O3
2-[4-(2-Hydroxyethyl)piperazin-1-yl]-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde chemical structure, C16H20N4O3, CAS 850228-84-1
2-[4-(2-Hydroxyethyl)piperazin-1-yl]-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde
CAS 850228-84-1C16H20N4O3
2-(4-Methylpiperazin-1-yl)-3-nitro-4H-pyrido[1,2-a]pyrimidin-4-one chemical structure, C13H15N5O3, CAS 62195-31-7
2-(4-Methylpiperazin-1-yl)-3-nitro-4H-pyrido[1,2-a]pyrimidin-4-one
CAS 62195-31-7C13H15N5O3
Ethyl 4-{4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl}piperazine-1-carboxylate chemical structure, C15H18N4O3, CAS 141277-99-8
Ethyl 4-{4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl}piperazine-1-carboxylate
CAS 141277-99-8C15H18N4O3
2-(4-{4-Oxo-4H-pyrido[1,2-a]pyrimidin-2-yl}piperazin-1-yl)-N-(propan-2-yl)propanamide chemical structure, C18H25N5O2, CAS 2741892-91-9
2-(4-{4-Oxo-4H-pyrido[1,2-a]pyrimidin-2-yl}piperazin-1-yl)-N-(propan-2-yl)propanamide
CAS 2741892-91-9C18H25N5O2