Murcko scaffold
3'-Phenyl-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione scaffold
46 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 21
- Chemicals
- 46
- With full pages
- 14
Scaffold SMILES
O=C1CSC2(C(=O)Nc3ccccc32)N1c1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 46 of 46 chemicals
![2',4-Dioxo-3-(4-methoxyphenyl)-5-methylspiro[1,3-thiazolidine-2,3'-indoline] chemical structure, C18H16N2O3S, CAS 91870-66-5](/s/XSQSECQRRRCUPN-UHFFFAOYSA-N.svg)
2',4-Dioxo-3-(4-methoxyphenyl)-5-methylspiro[1,3-thiazolidine-2,3'-indoline]
CAS 91870-66-5C18H16N2O3S
![3'-(4-Fluorophenyl)spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)-dione chemical structure, C16H11FN2O2S, CAS 79962-58-6](/s/YDCAABKMMODBCJ-UHFFFAOYSA-N.svg)
3'-(4-Fluorophenyl)spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)-dione
CAS 79962-58-6C16H11FN2O2S
![3'-(4-Methoxyphenyl)spiro[3H-indole-3,2'-thiazolidine]-2,4'-(1H)-dione chemical structure, C17H14N2O3S, CAS 59618-77-8](/s/RLJZCFZGIVVNEA-UHFFFAOYSA-N.svg)
3'-(4-Methoxyphenyl)spiro[3H-indole-3,2'-thiazolidine]-2,4'-(1H)-dione
CAS 59618-77-8C17H14N2O3S
![3'-Phenyl-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione chemical structure, C16H12N2O2S, CAS 79962-56-4](/s/YOUZPGWSTPAIRL-UHFFFAOYSA-N.svg)
3'-Phenyl-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione
CAS 79962-56-4C16H12N2O2S
![3-(4-Chlorophenyl)spiro[1,3-thiazolidine-2,3'-indoline]-4,7-dione chemical structure, C16H11ClN2O2S, CAS 79962-57-5](/s/YKFMTQNLMVSAKD-UHFFFAOYSA-N.svg)
3-(4-Chlorophenyl)spiro[1,3-thiazolidine-2,3'-indoline]-4,7-dione
CAS 79962-57-5C16H11ClN2O2S
![3'-[3-(Trifluoromethyl)phenyl]-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione chemical structure, C17H11F3N2O2S, CAS 79962-59-7](/s/HXVIYHCUUBIMCB-UHFFFAOYSA-N.svg)
3'-[3-(Trifluoromethyl)phenyl]-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione
CAS 79962-59-7C17H11F3N2O2S
![3-(4-Bromo-3-methylphenyl)spiro[1,3-thiazolidine-2,3'-1H-indole]-2',4-dione chemical structure, C17H13BrN2O2S, CAS 340988-37-6](/s/IHUAOIUAUWPILX-UHFFFAOYSA-N.svg)
3-(4-Bromo-3-methylphenyl)spiro[1,3-thiazolidine-2,3'-1H-indole]-2',4-dione
CAS 340988-37-6C17H13BrN2O2S
![3'-(3,4-Dichlorophenyl)-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione chemical structure, C16H10Cl2N2O2S, CAS 140234-12-4](/s/UNLUUNOLDOCFOJ-UHFFFAOYSA-N.svg)
3'-(3,4-Dichlorophenyl)-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione
CAS 140234-12-4C16H10Cl2N2O2S
![Ethyl 4-(2,4'-dioxospiro[indoline-3,2'-thiazolidin]-3'-yl)benzoate chemical structure, C19H16N2O4S, CAS 309285-81-2](/s/NEYXEKWNNJKINR-UHFFFAOYSA-N.svg)
Ethyl 4-(2,4'-dioxospiro[indoline-3,2'-thiazolidin]-3'-yl)benzoate
CAS 309285-81-2C19H16N2O4S
![3-(3-Bromophenyl)spiro[1,3-thiazolidine-2,3'-1H-indole]-2',4-dione chemical structure, C16H11BrN2O2S, CAS 140219-87-0](/s/MVXSGQMFLMVTGU-UHFFFAOYSA-N.svg)
3-(3-Bromophenyl)spiro[1,3-thiazolidine-2,3'-1H-indole]-2',4-dione
CAS 140219-87-0C16H11BrN2O2S
![Spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)-dione, 5'-methyl-3'-phenyl- chemical structure, C17H14N2O2S, CAS 91870-65-4](/s/JWYHVXCUFQZPFL-UHFFFAOYSA-N.svg)
Spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)-dione, 5'-methyl-3'-phenyl-
CAS 91870-65-4C17H14N2O2S
RefChem:314015
CAS 5951-53-1C16H11ClN2O2S
![3-(4-Propan-2-ylphenyl)spiro[1,3-thiazolidine-2,3'-1H-indole]-2',4-dione chemical structure, C19H18N2O2S, CAS 309266-80-6](/s/YKOSLKGEHSNDGD-UHFFFAOYSA-N.svg)
3-(4-Propan-2-ylphenyl)spiro[1,3-thiazolidine-2,3'-1H-indole]-2',4-dione
CAS 309266-80-6C19H18N2O2S
![3-(3-Chloro-4-methylphenyl)spiro[1,3-thiazolidine-2,3'-1H-indole]-2',4-dione chemical structure, C17H13ClN2O2S, CAS 296793-62-9](/s/TXKZSOMLBASWGF-UHFFFAOYSA-N.svg)
3-(3-Chloro-4-methylphenyl)spiro[1,3-thiazolidine-2,3'-1H-indole]-2',4-dione
CAS 296793-62-9C17H13ClN2O2S
![3'-(3-Chlorophenyl)-5'-methyl-1,3-dihydrospiro(2H-indole-3.2'-[1,3]-thiazolidine)-2,4'-dione chemical structure, C17H13ClN2O2S, CAS 140219-84-7](/s/ZYFBZYTXSHOPAP-UHFFFAOYSA-N.svg)
3'-(3-Chlorophenyl)-5'-methyl-1,3-dihydrospiro(2H-indole-3.2'-[1,3]-thiazolidine)-2,4'-dione
CAS 140219-84-7C17H13ClN2O2S
![3-(3-Fluorophenyl)spiro[1,3-thiazolidine-2,3'-1H-indole]-2',4-dione chemical structure, C16H11FN2O2S, CAS 140219-79-0](/s/YEZWAPGEWKTZQM-UHFFFAOYSA-N.svg)
3-(3-Fluorophenyl)spiro[1,3-thiazolidine-2,3'-1H-indole]-2',4-dione
CAS 140219-79-0C16H11FN2O2S
![3-(4-Ethoxyphenyl)-5-methylspiro[1,3-thiazolidine-2,3'-1H-indole]-2',4-dione chemical structure, C19H18N2O3S, CAS 296790-06-2](/s/HGYMKYLBIORRBA-UHFFFAOYSA-N.svg)
3-(4-Ethoxyphenyl)-5-methylspiro[1,3-thiazolidine-2,3'-1H-indole]-2',4-dione
CAS 296790-06-2C19H18N2O3S
![3-(3-Chloro-4-methylphenyl)-5-methylspiro[1,3-thiazolidine-2,3'-1H-indole]-2',4-dione chemical structure, C18H15ClN2O2S, CAS 309274-08-6](/s/OIRCYKHDIHHVRV-UHFFFAOYSA-N.svg)
3-(3-Chloro-4-methylphenyl)-5-methylspiro[1,3-thiazolidine-2,3'-1H-indole]-2',4-dione
CAS 309274-08-6C18H15ClN2O2S
![3-(4-Bromophenyl)-5-methylspiro[1,3-thiazolidine-2,3'-1H-indole]-2',4-dione chemical structure, C17H13BrN2O2S, CAS 91870-67-6](/s/OJAIXNTZONVTQR-UHFFFAOYSA-N.svg)
3-(4-Bromophenyl)-5-methylspiro[1,3-thiazolidine-2,3'-1H-indole]-2',4-dione
CAS 91870-67-6C17H13BrN2O2S
![3-(3-Fluorophenyl)-5-methylspiro[1,3-thiazolidine-2,3'-1H-indole]-2',4-dione chemical structure, C17H13FN2O2S, CAS 140219-80-3](/s/MHQISOBWZOYKML-UHFFFAOYSA-N.svg)
3-(3-Fluorophenyl)-5-methylspiro[1,3-thiazolidine-2,3'-1H-indole]-2',4-dione
CAS 140219-80-3C17H13FN2O2S
![3-(4-Ethoxyphenyl)spiro[1,3-thiazolidine-2,3'-indoline]-4,7-dione chemical structure, C18H16N2O3S, CAS 155425-87-9](/s/LQJSLCGBPXERQR-UHFFFAOYSA-N.svg)
3-(4-Ethoxyphenyl)spiro[1,3-thiazolidine-2,3'-indoline]-4,7-dione
CAS 155425-87-9C18H16N2O3S
![N-[4-(2',4-Dioxospiro[1,3-thiazolidine-2,3'-1H-indole]-3-yl)phenyl]acetamide chemical structure, C18H15N3O3S, CAS 364620-31-5](/s/YYWSYPRPVZJCON-UHFFFAOYSA-N.svg)
N-[4-(2',4-Dioxospiro[1,3-thiazolidine-2,3'-1H-indole]-3-yl)phenyl]acetamide
CAS 364620-31-5C18H15N3O3S
![3-(4-Bromophenyl)spiro[1,3-thiazolidine-2,3'-1H-indole]-2',4-dione chemical structure, C16H11BrN2O2S, CAS 116344-60-6](/s/PZHFCVQESLYHHY-UHFFFAOYSA-N.svg)
3-(4-Bromophenyl)spiro[1,3-thiazolidine-2,3'-1H-indole]-2',4-dione
CAS 116344-60-6C16H11BrN2O2S
![5'-Methyl-3-(4-methylphenyl)spiro[1,3-thiazolidine-2,3'-1H-indole]-2',4-dione chemical structure, C18H16N2O2S, CAS 155425-88-0](/s/QVGMCDLRKDXWBB-UHFFFAOYSA-N.svg)
5'-Methyl-3-(4-methylphenyl)spiro[1,3-thiazolidine-2,3'-1H-indole]-2',4-dione
CAS 155425-88-0C18H16N2O2S
- 10-Bromo-3-(4-ethoxyphenyl)spiro[1,3-thiazolidine-2,3'-indoline]-4,7-dione946387-38-8C18H15BrN2O3S
- 5-Bromo-3'-(4-chlorophenyl)-4'H-spiro[indole-3,2'-[1,3]thiazolidine]-2,4'(1H)-dione6477-75-4C16H10BrClN2O2S
- 5-Fluoro-3'-phenyl-4'H-spiro[indole-3,2'-[1,3]thiazolidine]-2,4'(1H)-dione89405-25-4C16H11FN2O2S
- 6-Fluoro-3'-phenyl-4'H-spiro[indole-3,2'-[1,3]thiazolidine]-2,4'(1H)-dione89405-30-1C16H11FN2O2S
- 3'-(3-Chloro-4-methoxyphenyl)-1-methyl-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione894564-15-9C18H15ClN2O3S
- 1-Methyl-3'-(3-methylphenyl)-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione894564-55-7C18H16N2O2S
- 2-[3'-(3-Fluorophenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]acetamide894551-12-3C18H14FN3O3S
- 2-(3'-(3,5-Dimethylphenyl)-2,4'-dioxospiro[indoline-3,2'-thiazolidin]-1-yl)acetamide894559-25-2C20H19N3O3S
- 2-[3'-(4-Methoxyphenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]acetamide894560-94-2C19H17N3O4S
- 3'-(4-Chlorophenyl)-1-methyl-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione158361-99-0C17H13ClN2O2S
- 3-(4-Methoxyphenyl)-5-methyl-1'-propanoylspiro[1,3-thiazolidine-2,3'-indole]-2',4-dione924822-26-4C21H20N2O4S
- 2-[3'-(3,4-Dimethylphenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]acetamide894557-57-4C20H19N3O3S
- 3'-(3-Fluorophenyl)-5-methyl-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione899743-33-0C17H13FN2O2S
- 3'-(3,5-Dimethylphenyl)-7-methylspiro[indoline-3,2'-thiazolidine]-2,4'-dione899986-96-0C19H18N2O2S
- 2-[3'-(4-Fluorophenyl)-5-methyl-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]acetamide899987-13-4C19H16FN3O3S
- 3'-(3-Fluorophenyl)-1-methyl-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione894563-91-8C17H13FN2O2S
- 3'-(3-Chloro-4-methylphenyl)-1-methyl-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione894564-31-9C18H15ClN2O2S
- 3'-(3-Fluoro-4-methylphenyl)-1-methyl-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione894564-39-7C18H15FN2O2S
- 1-Methyl-3'-(4-methylphenyl)-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione155425-92-6C18H16N2O2S
- 2-[3'-(4-Chlorophenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]acetamide894555-00-1C18H14ClN3O3S
- 2-(3'-(3,4-Difluorophenyl)-2,4'-dioxospiro[indoline-3,2'-thiazolidin]-1-yl)acetamide894563-04-3C18H13F2N3O3S
- 2-[5-Bromo-3'-(4-hydroxyphenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-5'-yl]acetic acid1092344-32-5C18H13BrN2O5S
Related scaffolds
Same ring framework with different atoms or bond orders
