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Murcko scaffold

Ring system with 4 rings and 24 atoms

10 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
10
With full pages
3
Scaffold SMILES

O=C1N=C(N2CCN(c3ccccc3)CC2)SC1=Cc1cccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1N=C(N2CCN(c3ccccc3)CC2)SC1=Cc1cccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 10 of 10 chemicals

(E)-2-(4-(4-Chlorophenyl)piperazin-1-yl)-5-(thiophen-2-ylmethylene)thiazol-4(5H)-one chemical structure, C18H16ClN3OS2, CAS 371125-36-9
(E)-2-(4-(4-Chlorophenyl)piperazin-1-yl)-5-(thiophen-2-ylmethylene)thiazol-4(5H)-one
CAS 371125-36-9C18H16ClN3OS2
(5E)-2-(4-Phenylpiperazin-1-yl)-5-(thiophen-2-ylmethylidene)-1,3-thiazol-4(5H)-one chemical structure, C18H17N3OS2, CAS 1164557-21-4
(5E)-2-(4-Phenylpiperazin-1-yl)-5-(thiophen-2-ylmethylidene)-1,3-thiazol-4(5H)-one
CAS 1164557-21-4C18H17N3OS2
(5E)-2-[4-(3-Methylphenyl)piperazin-1-yl]-5-[(thiophen-2-yl)methylidene]-4,5-dihydro-1,3-thiazol-4-one chemical structure, C19H19N3OS2
(5E)-2-[4-(3-Methylphenyl)piperazin-1-yl]-5-[(thiophen-2-yl)methylidene]-4,5-dihydro-1,3-thiazol-4-one
C19H19N3OS2
(E)-5-(Thiophen-2-ylmethylene)-2-(4-(m-tolyl)piperazin-1-yl)thiazol-4(5H)-one chemical structure, C19H19N3OS2, CAS 370849-37-9
(E)-5-(Thiophen-2-ylmethylene)-2-(4-(m-tolyl)piperazin-1-yl)thiazol-4(5H)-one
CAS 370849-37-9C19H19N3OS2
(5E)-2-[4-(3-Chloro-4-methylphenyl)piperazin-1-yl]-5-(thiophen-2-ylmethylidene)-1,3-thiazol-4(5H)-one chemical structure, C19H18ClN3OS2, CAS 370868-66-9
(5E)-2-[4-(3-Chloro-4-methylphenyl)piperazin-1-yl]-5-(thiophen-2-ylmethylidene)-1,3-thiazol-4(5H)-one
CAS 370868-66-9C19H18ClN3OS2
(5Z)-2-[4-(4-Methylphenyl)piperazin-1-yl]-5-(thiophen-2-ylmethylidene)-1,3-thiazol-4-one chemical structure, C19H19N3OS2
(5Z)-2-[4-(4-Methylphenyl)piperazin-1-yl]-5-(thiophen-2-ylmethylidene)-1,3-thiazol-4-one
C19H19N3OS2
2-[4-(4-Methylphenyl)-1-piperazinyl]-5-(2-thienylmethylene)-1,3-thiazol-4(5H)-one chemical structure, C19H19N3OS2, CAS 1164527-43-8
2-[4-(4-Methylphenyl)-1-piperazinyl]-5-(2-thienylmethylene)-1,3-thiazol-4(5H)-one
CAS 1164527-43-8C19H19N3OS2
(E)-5-(Thiophen-2-ylmethylene)-2-(4-(o-tolyl)piperazin-1-yl)thiazol-4(5H)-one chemical structure, C19H19N3OS2, CAS 1164546-85-3
(E)-5-(Thiophen-2-ylmethylene)-2-(4-(o-tolyl)piperazin-1-yl)thiazol-4(5H)-one
CAS 1164546-85-3C19H19N3OS2
(E)-5-(Thiophen-2-ylmethylene)-2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)thiazol-4(5H)-one chemical structure, C19H16F3N3OS2, CAS 843632-65-5
(E)-5-(Thiophen-2-ylmethylene)-2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)thiazol-4(5H)-one
CAS 843632-65-5C19H16F3N3OS2
(E)-2-(4-(2-Nitrophenyl)piperazin-1-yl)-5-(thiophen-2-ylmethylene)thiazol-4(5H)-one chemical structure, C18H16N4O3S2, CAS 369401-78-5
(E)-2-(4-(2-Nitrophenyl)piperazin-1-yl)-5-(thiophen-2-ylmethylene)thiazol-4(5H)-one
CAS 369401-78-5C18H16N4O3S2