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Murcko scaffold

Ring system with 4 rings and 24 atoms

27 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 24
Chemicals: 27
With full pages: 2

Scaffold SMILES

O=c1[nH]c2nc(Nc3ccccc3)ncc2cc1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=c1[nH]c2nc(Nc3ccccc3)ncc2cc1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 27 of 27 chemicals

6-(2,6-Dichlorophenyl)-8-methyl-2-((3-(methylthio)phenyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one chemical structure, C21H16Cl2N4OS, CAS 260415-63-2

6-(2,6-Dichlorophenyl)-8-methyl-2-((3-(methylthio)phenyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

CAS 260415-63-2C₂₁H₁₆Cl₂N₄OS

PD-166326 chemical structure, C21H16Cl2N4O2, CAS 185039-91-2

CAS 185039-91-2C₂₁H₁₆Cl₂N₄O₂

PD-180970 chemical structure, C21H15Cl2FN4O, CAS 287204-45-9

CAS 287204-45-9C₂₁H₁₅Cl₂FN₄O

6-(2,6-Dichlorophenyl)-2-((4-(2-(diethylamino)ethoxy)phenyl)amino)-8-methylpyrido(2,3-d)pyrimidin-7(8H)-one chemical structure, C26H27Cl2N5O2, CAS 185039-89-8

6-(2,6-Dichlorophenyl)-2-((4-(2-(diethylamino)ethoxy)phenyl)amino)-8-methylpyrido(2,3-d)pyrimidin-7(8H)-one

CAS 185039-89-8C₂₆H₂₇Cl₂N₅O₂

6-(2,6-Dichlorophenyl)-2-[(2-methoxyphenyl)amino]-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one chemical structure, C21H16Cl2N4O2, CAS 185039-80-9

6-(2,6-Dichlorophenyl)-2-[(2-methoxyphenyl)amino]-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one

CAS 185039-80-9C₂₁H₁₆Cl₂N₄O₂

6-(2,6-Dichlorophenyl)-2-[(3-methoxyphenyl)amino]-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one chemical structure, C21H16Cl2N4O2, CAS 185039-81-0

6-(2,6-Dichlorophenyl)-2-[(3-methoxyphenyl)amino]-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one

CAS 185039-81-0C₂₁H₁₆Cl₂N₄O₂

6-(2,6-Dichlorophenyl)-2-[(3-hydroxyphenyl)amino]-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one chemical structure, C20H14Cl2N4O2, CAS 185039-96-7

6-(2,6-Dichlorophenyl)-2-[(3-hydroxyphenyl)amino]-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one

CAS 185039-96-7C₂₀H₁₄Cl₂N₄O₂

6-(2,6-Dichlorophenyl)-2-[(4-hydroxyphenyl)amino]-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one chemical structure, C20H14Cl2N4O2, CAS 212391-57-6

6-(2,6-Dichlorophenyl)-2-[(4-hydroxyphenyl)amino]-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one

CAS 212391-57-6C₂₀H₁₄Cl₂N₄O₂

2-Aminopyrido[2,3-d]pyrimidin-7(8H)-one 53 chemical structure, C22H18Cl2N4O2, CAS 185039-82-1

2-Aminopyrido[2,3-d]pyrimidin-7(8H)-one 53

CAS 185039-82-1C₂₂H₁₈Cl₂N₄O₂

2-Aminopyrido[2,3-d]pyrimidin-7(8H)-one 54 chemical structure, C22H18Cl2N4O3, CAS 185039-92-3

2-Aminopyrido[2,3-d]pyrimidin-7(8H)-one 54

CAS 185039-92-3C₂₂H₁₈Cl₂N₄O₃

2-Aminopyrido[2,3-d]pyrimidin-7(8H)-one 56 chemical structure, C23H18Cl2N4O3, CAS 185039-97-8

2-Aminopyrido[2,3-d]pyrimidin-7(8H)-one 56

CAS 185039-97-8C₂₃H₁₈Cl₂N₄O₃

2-[4-(2-Aminoethoxy)anilino]-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidin-7-one chemical structure, C22H19Cl2N5O2, CAS 212391-58-7

2-[4-(2-Aminoethoxy)anilino]-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidin-7-one

CAS 212391-58-7C₂₂H₁₉Cl₂N₅O₂

6-(2,6-Dichlorophenyl)-2-({4-[2-(dimethylamino)ethoxy]phenyl}amino)-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one chemical structure, C24H23Cl2N5O2, CAS 717094-37-6

6-(2,6-Dichlorophenyl)-2-({4-[2-(dimethylamino)ethoxy]phenyl}amino)-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one

CAS 717094-37-6C₂₄H₂₃Cl₂N₅O₂

6-(2,6-Dichlorophenyl)-2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-ethyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one chemical structure, C27H29Cl2N5O2, CAS 212391-64-5

6-(2,6-Dichlorophenyl)-2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-ethyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one

CAS 212391-64-5C₂₇H₂₉Cl₂N₅O₂

3-((6-(2,6-Dichlorophenyl)-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)benzoic acid chemical structure, C21H14Cl2N4O3, CAS 185039-99-0

3-((6-(2,6-Dichlorophenyl)-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)benzoic acid

CAS 185039-99-0C₂₁H₁₄Cl₂N₄O₃

2-(4-(2-Diethylaminoethoxy)phenylamino)-8-ethyl-6-phenyl-8H-pyrido(2,3-d)pyrimidin-7-one chemical structure, C27H31N5O2, CAS 214983-24-1

2-(4-(2-Diethylaminoethoxy)phenylamino)-8-ethyl-6-phenyl-8H-pyrido(2,3-d)pyrimidin-7-one

CAS 214983-24-1C₂₇H₃₁N₅O₂

Pyrido(2,3-d)pyrimidin-7(8H)-one, 6-(2,6-dichlorophenyl)-2-((4-fluorophenyl)amino)-8-methyl- chemical structure, C20H13Cl2FN4O, CAS 305820-76-2

Pyrido(2,3-d)pyrimidin-7(8H)-one, 6-(2,6-dichlorophenyl)-2-((4-fluorophenyl)amino)-8-methyl-

CAS 305820-76-2C₂₀H₁₃Cl₂FN₄O

PD 166285 chemical structure, C26H29Cl4N5O2, CAS 212391-63-4

CAS 212391-63-4C₂₆H₂₉Cl₄N₅O₂

2-(4-Aminophenylamino)-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one chemical structure, C20H15Cl2N5O, CAS 648903-79-1

2-(4-Aminophenylamino)-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one

CAS 648903-79-1C₂₀H₁₅Cl₂N₅O

2-(3-Aminophenylamino)-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one chemical structure, C20H15Cl2N5O, CAS 648903-76-8

2-(3-Aminophenylamino)-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one

CAS 648903-76-8C₂₀H₁₅Cl₂N₅O

6-(2,6-Dichlorophenyl)-2-(4-ethoxyphenylamino)-8-ethyl-8H-pyrido[2,3-d]pyrimidin-7-one chemical structure, C23H20Cl2N4O2, CAS 185039-85-4

6-(2,6-Dichlorophenyl)-2-(4-ethoxyphenylamino)-8-ethyl-8H-pyrido[2,3-d]pyrimidin-7-one

CAS 185039-85-4C₂₃H₂₀Cl₂N₄O₂

6-(2,6-Dichlorophenyl)-8-ethyl-2-(4-methoxyphenylamino)-8H-pyrido[2,3-d]pyrimidin-7-one chemical structure, C22H18Cl2N4O2, CAS 185039-83-2

6-(2,6-Dichlorophenyl)-8-ethyl-2-(4-methoxyphenylamino)-8H-pyrido[2,3-d]pyrimidin-7-one

CAS 185039-83-2C₂₂H₁₈Cl₂N₄O₂

6-(2,6-Dichlorophenyl)-2-(3,4-dimethoxyphenylamino)-8-ethyl-8H-pyrido[2,3-d]pyrimidin-7-one chemical structure, C23H20Cl2N4O3, CAS 185039-86-5

6-(2,6-Dichlorophenyl)-2-(3,4-dimethoxyphenylamino)-8-ethyl-8H-pyrido[2,3-d]pyrimidin-7-one

CAS 185039-86-5C₂₃H₂₀Cl₂N₄O₃

8-Ethyl-4-methyl-6-phenyl-2-(phenylamino)pyrido[2,3-d]pyrimidin-7(8H)-one chemical structure, C22H20N4O, CAS 934496-72-7

8-Ethyl-4-methyl-6-phenyl-2-(phenylamino)pyrido[2,3-d]pyrimidin-7(8H)-one

CAS 934496-72-7C₂₂H₂₀N₄O