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Murcko scaffold

Ring system with 4 rings and 28 atoms

10 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
28
Chemicals
10
With full pages
3
Scaffold SMILES

O=C(Nc1cccc(Nc2nccc(-c3cccnc3)n2)c1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1cccc(Nc2nccc(-c3cccnc3)n2)c1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 10 of 10 chemicals

4-Methyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide chemical structure, C24H21N5O, CAS 152459-96-6
4-Methyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
CAS 152459-96-6C24H21N5O
Cgp-53716 chemical structure, C23H19N5O, CAS 152459-94-4
Cgp-53716
CAS 152459-94-4C23H19N5O
4-(Chloromethyl)-N-(4-methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)phenyl)benzamide chemical structure, C24H20ClN5O, CAS 404844-11-7
4-(Chloromethyl)-N-(4-methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)phenyl)benzamide
CAS 404844-11-7C24H20ClN5O
Nrc-AN-019 chemical structure, C25H17F6N5O, CAS 879507-25-2
Nrc-AN-019
CAS 879507-25-2C25H17F6N5O
4-(Chloromethyl)-N-4-methyl-3-[(4-(3-pyridinyl)-2-pyrimidinyl)amino]phenylbenzamide hydrochloride chemical structure, C24H21Cl2N5O, CAS 404844-10-6
4-(Chloromethyl)-N-4-methyl-3-[(4-(3-pyridinyl)-2-pyrimidinyl)amino]phenylbenzamide hydrochloride
CAS 404844-10-6C24H21Cl2N5O
Jnk-IN-2 chemical structure, C28H27N7O2, CAS 1408077-04-2
Jnk-IN-2
CAS 1408077-04-2C28H27N7O2
4-(Dichloromethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide chemical structure, C24H19Cl2N5O, CAS 581076-66-6
4-(Dichloromethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
CAS 581076-66-6C24H19Cl2N5O
4-Chloromethyl-N-[4-methyl-3-[[4-(1-oxido-3-pyridinyl)-2-pyrimidinyl]-amino]-phenyl]-benzamide chemical structure, C24H20ClN5O2, CAS 571187-02-5
4-Chloromethyl-N-[4-methyl-3-[[4-(1-oxido-3-pyridinyl)-2-pyrimidinyl]-amino]-phenyl]-benzamide
CAS 571187-02-5C24H20ClN5O2
4-[[4-(Dimethylamino)-1-oxobut-2-enyl]amino]-N-[3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide chemical structure, C28H27N7O2
4-[[4-(Dimethylamino)-1-oxobut-2-enyl]amino]-N-[3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide
C28H27N7O2
4-Des[(4-Methyl-1-piperazinyl)methyl]-4-formyl Imatinib chemical structure, C24H19N5O2, CAS 1219828-35-9
4-Des[(4-Methyl-1-piperazinyl)methyl]-4-formyl Imatinib
CAS 1219828-35-9C24H19N5O2