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Insecticides and acaricides

2,4-Dinitrophenol

Also known as Aldifen, Nitrophene, Dinofan

CAS 51-28-5Formula C6H4N2O5Molar mass 184.11 g/molEC 200-087-7
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Serious health hazard, Hazardous to the environment 59 suppliers listed
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2,4-Dinitrophenol chemical structure, C6H4N2O5, CAS 51-28-5
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Pale yellow platelets or leaflets from water
Melting point
114.8 ยฐC
Boiling point
Sublimes
Density
1.683 g/cmยณ at 24 ยฐC
Solubility
In water, 5,600 mg/L at 18 ยฐC, 43,000 mg/L at 100 ยฐC
HS code
290899
Category
Insecticides and acaricides
UN number
UN 0076
Illustrative photo, off-white crystalline powder in fibre drums in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is 2,4-Dinitrophenol?

Plain description, key identifiers and synonyms

2,4-dinitrophenol is a dinitrophenol having the nitro groups at the 2- and 4-positions. It has a role as a geroprotector, an antiseptic drug, an allergen, an oxidative phosphorylation inhibitor and a bacterial xenobiotic metabolite. It is a conjugate acid of a 2,4-dinitrophenol(1-).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2,4-dinitrophenol
CAS number
51-28-5 CAS number cross-checked
EC number
200-087-7
Molecular formula
C6H4N2O5
UNII
Q13SKS21MN
MDL number
MFCD00007115
InChIKey
UFBJCMHMOXMLKC-UHFFFAOYSA-N
InChI
InChI=1S/C6H4N2O5/c9-6-2-1-4(7(10)11)3-5(6)8(12)13/h1-3,9H
SMILES (canonical and isomeric)
C1=CC(=C(C=C1[N+](=O)[O-])[N+](=O)[O-])O

Synonyms

  • Aldifen
  • Nitrophene
  • Dinofan
  • Phenol, 2,4-dinitro-
  • Fenoxyl carbon N
  • Solfo Black B
  • Tertrosulphur PBR
  • alpha-Dinitrophenol
  • Solfo Black G
  • Nitro kleenup
  • 1-Hydroxy-2,4-dinitrobenzene
  • 2,4-Dnp
  • Chemox PE
  • Solfo Black BB
  • Solfo Black SB
  • Dinitrofenolo
  • Tertrosulphur Black PB
  • Solfo Black 2B Supra
  • 2,4-Dinitrofenol
  • Maroxol-50
  • Osmoplastic-R
  • Osmotox-Plus
  • Chemox
  • Mitcal
  • Camello mosquito coils
Show all 37 synonyms
  • Phenol, alpha-dinitro-
  • EK 102
  • 1'alpha-2,4-Dinitrophenol
  • Shirakiku brand mosquito coils
  • Fenoxyl
  • 2,4 Dinitrophenol
  • phenol, 2,4-dinitro
  • Nitrophen
  • Dinitrophenol
  • RCRA waste number P048
  • 2,4-dinitro-phenol
  • Tertrosulfur pbr

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Pale yellow platelets or leaflets from waterexp.
Odour
SWEET, MUSTY ODORexp.
Taste
BITTER TASTEexp.
Melting point
114.8 ยฐCexp.
Boiling point
Sublimesexp.
Density
1.683 g/cmยณ at 24 ยฐCexp.
Solubility
In water, 5,600 mg/L at 18 ยฐC, 43,000 mg/L at 100 ยฐCexp.
Vapour pressure
3.9 ร— 10โปโด mm Hg at 20 ยฐCexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
184.11 g/molcalc.
Exact mass
184.012 Dacalc.
LogP (octanol/water)
1.21calc.
Topological polar surface area
106.5 ร…ยฒcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
2calc.
Heavy atoms
13calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H300Fatal if swallowed.
  • H311Toxic in contact with skin.
  • H331Toxic if inhaled.
  • H372Causes damage to organs through prolonged or repeated exposure.
  • H400Very toxic to aquatic life.
Precautionary statements (20)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P316Get emergency medical help immediately.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 0076
Transport hazard class
1.1
Packing group
I

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

2,4-Dinitrophenol suppliers

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All 59 suppliers
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Where suppliers are based

59 suppliers in 14 countries

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2,4-Dinitrophenol price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

The active ingredient is no longer contained in any registered pesticide products ... "cancelled.".

Manufacture of dyes and diaminophenol, wood preservative, insecticide, as indicator, as reagent for detection of potassium and ammonium ions.

Chemical intermediate for ci sulfur black 1, ci sulfur black 2, photochemicals & explosives, acid-base indicator, fungicide for protection of metal-cutting oil emulsions.

2,4-Dinitrophenol is used in the manufacture of dyes and wood preservatives, as a pesticide, and as an indicator for the detection of potassium and ammonium ions. During the 1930s, 2,4-dinitrophenol was used as a diet pill, but this use was stopped in 1938.

Pharmacological actions

  • Coloring Agents
  • Uncoupling Agents

Roles

  • aetiopathogenetic role
  • allergen
  • antiinfective agent
  • antiseptic drug
  • bacterial metabolite
  • bacterial xenobiotic metabolite
  • geroprotector
  • metabolite
  • oxidative phosphorylation inhibitor
  • pharmaceutical
  • prokaryotic metabolite
  • protective agent
  • xenobiotic metabolite

How it is made

Hydrolysis of 2,4-dinitro-1-chlorobenzene with sodium hydroxide.

(a) By heating phenol with dilute sulfuric acid, cooling the product, and then nitrating, keeping the temperature approximately 50 ยฐC, (b) by nitration with mixed acid with careful temperature control. (Dinitrophenol)

2,4-Dinitrochlorobenzene is hydrolyzed by heating with 6% aqueous sodium hydroxide at 95 - 100 ยฐC for 4 hr. The product is precipitated by addition of acid, filtered off, and washed to remove acid and also a small quantity of the more soluble 2,6-isomer. The yield is 95 %.

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 609-041-00-4

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Dinitrophenol isomers, Ref no: 151, Annex ref: II/151

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code 2,4-Dinitrophenol is traded under.

HS 2908.99Indicative HS code

Halogenated, sulphonated, nitrated or nitrosated derivatives of phenols orโ€ฆ

World exports in 2024
$77.7M
+4.6% vs 2023, imports $83.7M
2019 to 2024
Top exporters
  1. China32.2%
  2. India * partner reported22.2%
  3. Spain8.5%
Top importers
  1. United States13.9%
  2. Spain10.6%
  3. Turkey8.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for 2,4-Dinitrophenol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about 2,4-Dinitrophenol, based on the data on this page

What is 2,4-Dinitrophenol?

2,4-dinitrophenol is a dinitrophenol having the nitro groups at the 2- and 4-positions. It has a role as a geroprotector, an antiseptic drug, an allergen, an oxidative phosphorylation inhibitor and a bacterial xenobiotic metabolite. It is a conjugate acid of a 2,4-dinitrophenol(1-).

What is the CAS number of 2,4-Dinitrophenol?

The CAS registry number of 2,4-Dinitrophenol is 51-28-5.

What is the molecular formula and weight of 2,4-Dinitrophenol?

The molecular formula of 2,4-Dinitrophenol is C6H4N2O5 and its molar mass is 184.11 g/mol.

What is 2,4-Dinitrophenol used for?

The active ingredient is no longer contained in any registered pesticide products ... "cancelled.". Manufacture of dyes and diaminophenol, wood preservative, insecticide, as indicator, as reagent for detection of potassium and ammonium ions.

Is 2,4-Dinitrophenol hazardous?

2,4-Dinitrophenol carries the GHS signal word "Danger". Main hazards: fatal if swallowed, toxic in contact with skin, toxic if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of 2,4-Dinitrophenol?

2,4-Dinitrophenol is usually classified under HS code 290899 (Halogenated, sulphonated, nitrated or nitrosated derivatives of phenols orโ€ฆ). This is indicative, confirm it with your customs broker before shipping.

Where can I buy 2,4-Dinitrophenol?

CompoundList lists 59 suppliers of 2,4-Dinitrophenol in United States, China, Germany, India and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy 2,4-Dinitrophenol in India?

4 suppliers in India list 2,4-Dinitrophenol on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of 2,4-Dinitrophenol?

Suppliers quote 2,4-Dinitrophenol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle 2,4-Dinitrophenol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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