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2-Hydroxy-4-methoxybenzophenone

Also known as oxybenzone, Benzophenone-3, 2-Benzoyl-5-methoxyphenol

CAS 131-57-7Formula C14H12O3Molar mass 228.25 g/molEC 205-031-5
GHS signal word: Warning. Pictograms: Harmful or irritant, Hazardous to the environment 181 suppliers listed Drug substance
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2-Hydroxy-4-methoxybenzophenone chemical structure, C14H12O3, CAS 131-57-7
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless crystals
Melting point
65.5 °C
Boiling point
150 to 160
Density
1.32 at 25 °C
Flash point
100 °C
HS code
291450
Category
UV filters
Illustrative photo, colourless crystals in small glass vials on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is 2-Hydroxy-4-methoxybenzophenone?

Plain description, key identifiers and synonyms

Oxybenzone is a hydroxybenzophenone that is benzophenone which is substituted at the 2- and 4-positions of one of the benzene rings by hydroxy and methoxy groups respectively. It has a role as a xenobiotic, a dermatologic drug, a protective agent, an ultraviolet filter and an environmental contaminant. It is a hydroxybenzophenone and a monomethoxybenzene.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2-hydroxy-4-methoxyphenyl)-phenylmethanone
CAS number
131-57-7 CAS number cross-checked
EC number
205-031-5
Molecular formula
C14H12O3
UNII
95OOS7VE0Y
MDL number
MFCD00008387
INCI name
BENZOPHENONE-3
InChIKey
DXGLGDHPHMLXJC-UHFFFAOYSA-N
InChI
InChI=1S/C14H12O3/c1-17-11-7-8-12(13(15)9-11)14(16)10-5-3-2-4-6-10/h2-9,15H,1H3
SMILES (canonical and isomeric)
COC1=CC(=C(C=C1)C(=O)C2=CC=CC=C2)O

Synonyms

  • oxybenzone
  • Benzophenone-3
  • 2-Benzoyl-5-methoxyphenol
  • Advastab 45
  • Methanone, (2-hydroxy-4-methoxyphenyl)phenyl-
  • Oxybenzon
  • Anuvex
  • 4-Methoxy-2-hydroxybenzophenone
  • Ongrostab HMB
  • Oxibenzona
  • Usaf cy-9
  • Spectra-sorb UV 9
  • Chimassorb 90
  • Oxybenzonum
  • Uvinul 9
  • Syntase 62
  • Uvistat 24
  • Cyasorb UV 9
  • Sunscreen UV-15
  • (2-hydroxy-4-methoxyphenyl)-phenylmethanone
  • Uvinul M40
  • Escalol 567
  • Oxibenzonum
  • (2-Hydroxy-4-methoxyphenyl)phenylmethanone
  • Cyasorb UV 9 Light Absorber
Show all 36 synonyms
  • Viosorb 110
  • Benzophenone, 2-hydroxy-4-methoxy-
  • Tinosorb b 3
  • Uvinul 40
  • Bebak Baby Sun
  • 2-Hydroxy-4-methoxybenzophenone,(2-Hydroxy-4-methoxyphenyl)phenylmethanone
  • 2-hydroxy-4-methoxybenzone
  • Eusolex-4360
  • HMBP cpd
  • (2-hydroxy-4-methoxyphenyl)(phenyl)methanone
  • Eusolex 4360

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless crystalsexp.
Odour
Weak odorexp.
Melting point
65.5 °Cexp.
Boiling point
150 to 160exp.
Density
1.32 at 25 °Cexp.
Flash point
100 °Cexp.
Solubility
In water, 3.7 mg/L at 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
228.25 g/molcalc.
Exact mass
228.0786 Dacalc.
LogP (octanol/water)
2.63calc.
Topological polar surface area
46.53 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
3calc.
Heavy atoms
17calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.07calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(c1ccccc1)c1ccccc1

O=C(c1ccccc1)c1ccccc1

2 rings, 14 atoms, the Benzophenone ring system.

5,108 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
  • H400Very toxic to aquatic life.
  • H411Toxic to aquatic life with long lasting effects.
Precautionary statements (18)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

2-Hydroxy-4-methoxybenzophenone suppliers

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Where suppliers are based

181 suppliers in 24 countries

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2-Hydroxy-4-methoxybenzophenone price

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Uses and applications

What the substance is used for, by industry and function

Sunscreening Agents.

An ultraviolet light absorber and stabilizer, especially in plastics and paints.

Benzophenone-3 (BZ-3) is one of the UV-absorbing agents that has been used in industry and medicine for more than 30 years. Millions of consumers are exposed to benzophenones on a daily basis owing to the widespread use of these compounds in many of the products on the market, such as lipsticks, hair sprays, hair dyes, shampoo and detergent bars and sunscreen lotions. ...

Industrial uses: UV stabilizer.

Consumer uses: UV stabilizer, Fragrance.

Use classes: Cosmetics.

Cosmetic ingredient, INCI name BENZOPHENONE-3(light stabilizer, uv absorber, uv filter)

Pharmacological actions

  • Sunscreening Agents

Roles

  • dermatologic drug
  • environmental contaminant
  • pharmaceutical
  • photochemical role
  • protective agent
  • ultraviolet filter
  • xenobiotic

Functional uses

  • Fragrance
  • UV stabilizer

Cosmetic functions

  • Light stabilizer
  • UV absorber
  • UV filter

Pharmacology

Oxybenzone is a benzophenone derivative used as a sunscreen agent. Oxybenzone absorbs UVB and UVA II rays, resulting in a photochemical excitation and absorption of energy. Upon return to ground state, the absorbed energy results in emission of longer wavelength radiation and decreased skin penetration of radiation which reduces the risk of DNA damage.

How it is made

Benzoic acid is condensed with resorcinol monomethyl ether by heating in presence of ZnCl2, polyphosphoric acid (103% H3PO4 equivalent), and PCl3.

Benzophenone-3 is prepared by the Friedel-Crafts reaction of benzoyl chloride with 3-hydroxyanisole. The product is then recrystallized from water/methanol and dried.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • EU Cosmetics Regulation Annex VI, allowed UV filter
    Name: BENZOPHENONE-3, Ref no: 4, Annex ref: VI/4
  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code 2-Hydroxy-4-methoxybenzophenone is traded under.

HS 2914.50Indicative HS code

Ketone-phenols and ketones with other oxygen function

World exports in 2024
$438M
+10.9% vs 2023, imports $420M
2019 to 2024
Top exporters
  1. China50.5%
  2. India * partner reported11.6%
  3. United States11.3%
Top importers
  1. United States20.8%
  2. Germany10.0%
  3. Netherlands8.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for 2-Hydroxy-4-methoxybenzophenone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about 2-Hydroxy-4-methoxybenzophenone, based on the data on this page

What is 2-Hydroxy-4-methoxybenzophenone?

Oxybenzone is a hydroxybenzophenone that is benzophenone which is substituted at the 2- and 4-positions of one of the benzene rings by hydroxy and methoxy groups respectively. It has a role as a xenobiotic, a dermatologic drug, a protective agent, an ultraviolet filter and an environmental contaminant.

What is the CAS number of 2-Hydroxy-4-methoxybenzophenone?

The CAS registry number of 2-Hydroxy-4-methoxybenzophenone is 131-57-7.

What is the molecular formula and weight of 2-Hydroxy-4-methoxybenzophenone?

The molecular formula of 2-Hydroxy-4-methoxybenzophenone is C14H12O3 and its molar mass is 228.25 g/mol.

What is 2-Hydroxy-4-methoxybenzophenone used for?

Sunscreening Agents. An ultraviolet light absorber and stabilizer, especially in plastics and paints. Benzophenone-3 (BZ-3) is one of the UV-absorbing agents that has been used in industry and medicine for more than 30 years.

Is 2-Hydroxy-4-methoxybenzophenone hazardous?

2-Hydroxy-4-methoxybenzophenone carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of 2-Hydroxy-4-methoxybenzophenone?

2-Hydroxy-4-methoxybenzophenone is usually classified under HS code 291450 (Ketone-phenols and ketones with other oxygen function). This is indicative, confirm it with your customs broker before shipping.

Where can I buy 2-Hydroxy-4-methoxybenzophenone?

CompoundList lists 181 suppliers of 2-Hydroxy-4-methoxybenzophenone in China, United States, India, United Kingdom and 20 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy 2-Hydroxy-4-methoxybenzophenone in India?

18 suppliers in India list 2-Hydroxy-4-methoxybenzophenone on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of 2-Hydroxy-4-methoxybenzophenone?

Suppliers quote 2-Hydroxy-4-methoxybenzophenone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle 2-Hydroxy-4-methoxybenzophenone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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