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Steroids and sterols

25-Hydroxycholesterol

Also known as Cholest-5-ene-3beta,25-diol, 5-Cholestene-3beta,25-diol, (3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol

CAS 2140-46-7Formula C27H46O2Molar mass 402.66 g/molEC 635-752-4
GHS signal word: Warning. Pictograms: Harmful or irritant, Serious health hazard 36 suppliers listed
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25-Hydroxycholesterol chemical structure, C27H46O2, CAS 2140-46-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
2140-46-7
Formula
C27H46O2
Molar mass
402.66 g/mol
EC number
635-752-4
HS code
290613
Category
Steroids and sterols

What is 25-Hydroxycholesterol?

Plain description, key identifiers and synonyms

25-hydroxycholesterol is a 25-hydroxy steroid and an oxysterol. It has a role as a human metabolite. It is functionally related to a cholesterol.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
CAS number
2140-46-7 CAS number cross-checked
EC number
635-752-4
Molecular formula
C27H46O2
UNII
767JTD2N31
MDL number
MFCD00057815
InChIKey
INBGSXNNRGWLJU-ZHHJOTBYSA-N
InChI
InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1
Canonical SMILES
CC(CCCC(C)(C)O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C
Isomeric SMILES
C[C@H](CCCC(C)(C)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C

Synonyms

  • Cholest-5-ene-3beta,25-diol
  • 5-Cholestene-3beta,25-diol
  • (3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
  • 5-cholesten-3beta,25-diol
  • cholest-5-ene-3 beta,25-diol
  • (3S,8S,9S,10R,13R,14S,17R)-17-((2R)-6-Hydroxy-6-Methylheptan-2-Yl)-10,13-Dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-Dodecahydro-1H-Cyclopenta(A)Phenanthren-3-Ol
  • 25-hydroxy cholesterol
  • 25-hydroxy-cholesterol
  • cholest-5-en-3beta,25-diol
  • Cholest-5-ene-3,25-diol
  • (3S,8S,9S,10R,13R,14S,17R)-17-[(1R)-5-hydroxy-1,5-dimethyl-hexyl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
  • (3Beta)-cholest-5-ene-3,25-diol
  • 25-Hydroxycholest-5-en-3-ol
  • Cholest-5-ene-3,25-diol, (3b)-
  • 25-Hydroxycholesterol?
  • Cholest-5-en-3b,25-diol
  • 5-cholesten-3beta, 25-diol
  • 25-Hydroxycholesterol (25OH)
  • 25-Hydroxycholesterol, >=98%
  • (3beta,14beta,17alpha)-cholest-5-ene-3,25-diol
  • cholest-?5-?ene-?3|A,?25-?diol, 25-hydroxycholesterol
  • (1S,2R,5S,10S,11S,14R,15R)-14-[(2R)-6-hydroxy-6-methylheptan-2-yl]-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-ol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
402.66 g/molcalc.
Exact mass
402.3498 Dacalc.
LogP (octanol/water)
6.5calc.
Topological polar surface area
40.46 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
5calc.
Heavy atoms
29calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.93calc.
Formal charge
0calc.
Stereocentres
8calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1=C2CCCCC2C2CCC3CCCC3C2C1

C1=C2CCCCC2C2CCC3CCCC3C2C1

4 rings, 17 atoms.

1,163 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H312Harmful in contact with skin.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H332Harmful if inhaled.
  • H335May cause respiratory irritation.
  • H373May cause damage to organs through prolonged or repeated exposure.
Precautionary statements (21)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P317Get medical help.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

25-Hydroxycholesterol suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 36 suppliers
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Where suppliers are based

36 suppliers in 7 countries

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25-Hydroxycholesterol price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • animal metabolite
  • eukaryotic metabolite
  • human metabolite
  • mammalian metabolite
  • metabolite

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code 25-Hydroxycholesterol is traded under.

HS 2906.13Indicative HS code

Sterols and inositols

World exports in 2024
$316M
−12.1% vs 2023, imports $291M
2019 to 2024
Top exporters
  1. China42.0%
  2. United States16.4%
  3. Netherlands9.6%
Top importers
  1. Ecuador * partner reported13.0%
  2. China13.0%
  3. United States9.4%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for 25-Hydroxycholesterol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about 25-Hydroxycholesterol, based on the data on this page

What is 25-Hydroxycholesterol?

25-hydroxycholesterol is a 25-hydroxy steroid and an oxysterol. It has a role as a human metabolite. It is functionally related to a cholesterol.

What is the CAS number of 25-Hydroxycholesterol?

The CAS registry number of 25-Hydroxycholesterol is 2140-46-7.

What is the molecular formula and weight of 25-Hydroxycholesterol?

The molecular formula of 25-Hydroxycholesterol is C27H46O2 and its molar mass is 402.66 g/mol.

What is 25-Hydroxycholesterol used for?

Known uses and roles of 25-Hydroxycholesterol include animal metabolite, eukaryotic metabolite, human metabolite, mammalian metabolite and metabolite.

Is 25-Hydroxycholesterol hazardous?

25-Hydroxycholesterol carries the GHS signal word "Warning". Main hazards: harmful if swallowed, harmful in contact with skin, causes skin irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of 25-Hydroxycholesterol?

25-Hydroxycholesterol is usually classified under HS code 290613 (Sterols and inositols). This is indicative, confirm it with your customs broker before shipping.

Where can I buy 25-Hydroxycholesterol?

CompoundList lists 36 suppliers of 25-Hydroxycholesterol in China, United States, Czech Republic, Spain and 3 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of 25-Hydroxycholesterol?

Suppliers quote 25-Hydroxycholesterol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle 25-Hydroxycholesterol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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