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Central nervous system drugs

3,4-Methylenedioxymethamphetamine

Also known as MDMA, Ecstasy, Midomafetamine

CAS 42542-10-9Formula C11H15NO2Molar mass 193.25 g/molEC 980-806-5
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant Prohibited, not for trade
Why it is not for trade
3,4-Methylenedioxymethamphetamine chemical structure, C11H15NO2, CAS 42542-10-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
42542-10-9
Formula
C11H15NO2
Appearance
Oil
Boiling point
100 to 110
HS code
293299
Category
Central nervous system drugs

What is 3,4-Methylenedioxymethamphetamine?

Plain description, key identifiers and synonyms

3,4-methylenedioxymethamphetamine is a member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5. It has a role as a neurotoxin. It is a member of amphetamines and a member of benzodioxoles.

3,4-Methylenedioxymethamphetamine is an empathogen and stimulant.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-(1,3-benzodioxol-5-yl)-N-methylpropan-2-amine
CAS number
42542-10-9 CAS number cross-checked
EC number
980-806-5
Molecular formula
C11H15NO2
UNII
KE1SEN21RM
InChIKey
SHXWCVYOXRDMCX-UHFFFAOYSA-N
InChI
InChI=1S/C11H15NO2/c1-8(12-2)5-9-3-4-10-11(6-9)14-7-13-10/h3-4,6,8,12H,5,7H2,1-2H3
SMILES (canonical and isomeric)
CC(CC1=CC2=C(C=C1)OCO2)NC

Synonyms

  • MDMA
  • Ecstasy
  • Midomafetamine
  • Methylenedioxymethamphetamine
  • DL-(3,4-Methylenedioxy)methamphetamine
  • N-Methyl-3,4-methylenedioxyamphetamine
  • (RS)-3,4-(methylenedioxy)methamphetamine
  • N,alpha-Dimethyl-1,3-benzodioxole-5-ethanamine
  • 1-(1,3-benzodioxol-5-yl)-N-methylpropan-2-amine
  • midomafetamina
  • Methylenedioxymetamphetamine
  • Methylenedioxymethamfetamine
  • (+-)-(3,4-Methylenedioxy)methamphetamine
  • 1,3-Benzodioxole-5-ethanamine, N,alpha-dimethyl-
  • 3,4-methylenedioxymetamphetamine
  • Mandy [Street Name]
  • Molly [Street Name]
  • XTC [Street Name]
  • Phenethylamine, N,alpha-dimethyl-3,4-methylenedioxy-
  • 3,4-Methylenedioxy-N,alpha-dimethyl-beta-phenylethylamine
  • (+-)-N-Methyl-1-(3,4-methylenedioxyphenyl)-2-aminopropane
  • Mandy (Street Name)
  • Molly (Street Name)
  • XTC (Street Name)
  • [1-(2H-1,3-benzodioxol-5-yl)propan-2-yl](methyl)amine
Show all 37 synonyms
  • Ecstasy (Drug)
  • midomafetaminum
  • (1-(2H-1,3-benzodioxol-5-yl)propan-2-yl)(methyl)amine
  • N Methyl 3,4 methylenedioxyamphetamine
  • N Methyl 3,4 methylenedioxyamphetamine Hydrochloride
  • Hydrochloride, N-Methyl-3,4-methylenedioxyamphetamine
  • Molly
  • MANDY
  • DEA No. 7405
  • (+-)-N-Methyl-3,4-(methylenedioxy)amphetamine
  • XTC
  • 1-(1,3-Benzodioxol-5-yl)-N-methyl-2-propanamine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Oilexp.
Boiling point
100 to 110exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
193.25 g/molcalc.
Exact mass
193.1103 Dacalc.
LogP (octanol/water)
1.57calc.
Topological polar surface area
30.49 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
3calc.
Heavy atoms
14calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.46calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)OCO2

c1ccc2c(c1)OCO2

2 rings, 9 atoms, the 1,3-Benzodioxole ring system.

4,560 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H301Toxic if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (19)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

3,4-Methylenedioxymethamphetamine suppliers

Trading restrictions apply to this substance

Psychotropic substance

3,4-Methylenedioxymethamphetamine is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Convention on Psychotropic Substances 1971 Schedule I

Our policy on controlled substances

3,4-Methylenedioxymethamphetamine price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

3,4-Methylenedioxymethamphetamine (MDMA) (DEA Code Number: 7405) is a Schedule I controlled substance.

Schedule I Controlled Substance: (A) The drug or other substance has a high potential for abuse, (B) The drug or other substance has no currently accepted medical use in treatment in the United States, and (C) There is a lack of accepted safety for use of the drug or other substance under medical supervision.

Hallucinogens Serotonin Agents, Adrenergic Uptake Inhibitors.

Ecstasy is the popular name for the illicit drug MDMA and is widely used at dance parties or "raves." It is usually consumed orally in tablet or capsule form ... Its primary effect is to produce a positive mood state with euphoria, intimacy, and closeness to others.

Use classes: Illicit drugs and related compounds, Pharmaceuticals.

Industries and functions

Pharmacological actions

  • Adrenergic Uptake Inhibitors
  • Hallucinogens
  • Serotonin Agents

Roles

  • aetiopathogenetic role
  • neurotoxin
  • poison

Functional uses

  • Pharmaceutical

Pharmacology

3,4-Methylenedioxymethamphetamine is a ring-substituted amphetamine derivative, structurally related to the hallucinogen mescaline, with entactogenic, neurotoxic, and motor-stimulatory activities. 3,4-methylenedioxymethamphetamine (MDMA) produces an acute, rapid enhancement in both the release of serotonin from and the inhibition of serotonin reuptake by serotonergic nerve endings in the brain.

Read more

Once within the cell, MDMA depletes stores of tryptophan hydroxylase (TPH) via acute oxidative inactivation, in turn, depleted stores of TPH leave cell terminals open to damage from oxidative stress, possibly a source of MDMA neurotoxicity. This agent also induces norepinephrine, dopamine, and acetylcholine release and can act directly on a number of receptors, including alpha 2-adrenergic and 5-hydroxytryptamine (5-HT) 2A receptors. MDMA may suppress the dyskinesia associated with long-term use of L-dopamine (L-DOPA) without affecting the efficacy of L-DOPA treatment.

How it is made

There are four principal precursors which can be used in the manufacture of MDMA and related drugs: safrole, isosafrole, piperonal and 3,4-methylenedioxyphenyl-2-propanone (PMK). Safrole is the key starting material in so far as the other three can be synthesised from it. In the original Merck patent of 1914, safrole was reacted with hydrobromic acid to form bromosafrole, which was converted to MDMA using methylamine. Many illicit syntheses start with PMK and use either the Leuckart route or various reductive aminations including the aluminium foil method. All of these methods produce racemic MDMA.

Preparation: Germany patent 274350 (1914 to E. Merck).

Regulatory status

Inventories, regulations and trade controls that list this substance

Psychotropic substance

3,4-Methylenedioxymethamphetamine is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Convention on Psychotropic Substances 1971 Schedule I

Our policy on controlled substances

Controls

  • US DEA controlled substance or listed chemical
  • Controlled psychotropic substance

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code 3,4-Methylenedioxymethamphetamine is traded under.

HS 2932.99Indicative HS code

Heterocyclic compounds with oxygen hetero-atom(s) only, other

World exports in 2024
$3.81B
+10.3% vs 2023, imports $7.05B
2019 to 2024
Top exporters
  1. China28.9%
  2. Switzerland * partner reported12.7%
  3. Germany7.8%
Top importers
  1. United States49.7%
  2. China11.9%
  3. India * partner reported3.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for 3,4-Methylenedioxymethamphetamine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about 3,4-Methylenedioxymethamphetamine, based on the data on this page

What is 3,4-Methylenedioxymethamphetamine?

3,4-methylenedioxymethamphetamine is a member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5. It has a role as a neurotoxin. It is a member of amphetamines and a member of benzodioxoles.

What is 3,4-Methylenedioxymethamphetamine used for?

3,4-Methylenedioxymethamphetamine (MDMA) (DEA Code Number: 7405) is a Schedule I controlled substance.

Is 3,4-Methylenedioxymethamphetamine hazardous?

3,4-Methylenedioxymethamphetamine carries the GHS signal word "Danger". Main hazards: toxic if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

Can I buy 3,4-Methylenedioxymethamphetamine on CompoundList?

No. 3,4-Methylenedioxymethamphetamine is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle 3,4-Methylenedioxymethamphetamine

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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