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Impurities and reference standards

6beta-Hydroxycortisol

Also known as 6 beta-hydroxycortisol, (6R,8S,9S,10R,11S,13S,14S,17R)-6,11,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one, 6beta,11beta,17alpha,21-Tetrahydroxypregn-4-en-3,20-dione

CAS 53-35-0Formula C21H30O6Molar mass 378.47 g/molEC 641-848-7
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 4 suppliers listed
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6beta-Hydroxycortisol chemical structure, C21H30O6, CAS 53-35-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
53-35-0
Formula
C21H30O6
Molar mass
378.47 g/mol
EC number
641-848-7
HS code
291440
Category
Impurities and reference standards

What is 6beta-Hydroxycortisol?

Plain description, key identifiers and synonyms

6beta-hydroxycortisol is a C21-steroid that is cortisol bearing an additional hydroxy substituent at the 6beta-position. In humans, it is produced as a metabolite of cortisol by cytochrome p450-3A4 (CYP3A4, an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds) and can be used to detect moderate and potent CYP3A4 inhibition in vivo. It has a role as a probe, a mammalian metabolite and a human metabolite. It is a primary alpha-hydroxy ketone, a tertiary alpha-hydroxy ketone, a 17alpha-hydroxy steroid, a 21-hydroxy steroid, an 11beta-hydroxy steroid, a 6beta-hydroxy steroid, a 20-oxo steroid, a 3-oxo-Delta(4) steroid and a C21-steroid. It is functionally related to a cortisol.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(6R,8S,9S,10R,11S,13S,14S,17R)-6,11,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
CAS number
53-35-0Other or deprecated CAS: 174866-45-6, 3078-34-0
EC number
641-848-7
Molecular formula
C21H30O6
UNII
J37WKJ5Y50
MDL number
MFCD00200405
InChIKey
GNFTWPCIRXSCQF-UJXAPRPESA-N
InChI
InChI=1S/C21H30O6/c1-19-5-3-11(23)7-14(19)15(24)8-12-13-4-6-21(27,17(26)10-22)20(13,2)9-16(25)18(12)19/h7,12-13,15-16,18,22,24-25,27H,3-6,8-10H2,1-2H3/t12-,13-,15+,16-,18+,19-,20-,21-/m0/s1
Canonical SMILES
CC12CCC(=O)C=C1C(O)CC1C2C(O)CC2(C)C1CCC2(O)C(=O)CO
Isomeric SMILES
C[C@]12CCC(=O)C=C1[C@@H](C[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O)O

Synonyms

  • 6 beta-hydroxycortisol
  • (6R,8S,9S,10R,11S,13S,14S,17R)-6,11,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
  • 6beta,11beta,17alpha,21-Tetrahydroxypregn-4-en-3,20-dione
  • 6beta,11beta,17,21-tetrahydroxypregn-4-ene-3,20-dione
  • (6R,8S,9S,10R,11S,13S,14S,17R)-6,11,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta(a)phenanthren-3-one
  • 6,11 beta,17,21-tetrahydroxypregn-4-ene-3,20-dione
  • Hydrocortisone EP Impurity D
  • 6b-Hydroxy Cortisol
  • 6beta-Hydroxy cortisol
  • 6-beta-hydroxycortisol
  • 6|A-Hydroxycortisol
  • 6beta,17-Dihydroxycorticosterone
  • 6beta,11beta,17,21-Tetrahydroxypregn-4-ene-3,20-dione (6beta-Hydroxyhydrocortisone)
  • 6beta-HO-cortisol
  • 6beta-OH-cortisol
  • Corticosterone, 6beta,17-dihydroxy-
  • Pregn-4-ene-3,20-dione, 6beta,11beta,17,21-tetrahydroxy-
  • 6beta-hydroxyhydrocortisone
  • Hydrocortisone impurity d
  • 6,11beta,17,21-Tetrahydroxypregn-4-ene-3,20-dione
  • 4-pregnene-6beta,11beta,17alpha,21-tetrol-3,20-dione
  • (6beta,11beta)-6,11,17,21-tetrahydroxypregn-4-ene-3,20-dione
  • Pregn-4-en-3,20-dione, 6,11,17,21-tetrahydroxy-, (6beta,11beta)-
  • Pregn-4-ene-3,20-dione, 6,11,17,21-tetrahydroxy-, (6beta,11.beta.)-
  • 6,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
378.47 g/molcalc.
Exact mass
378.2042 Dacalc.
LogP (octanol/water)
0.75calc.
Topological polar surface area
115.1 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
2calc.
Heavy atoms
27calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.81calc.
Formal charge
0calc.
Stereocentres
8calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=C2CCC3C4CCCC4CCC3C2CC1

O=C1C=C2CCC3C4CCCC4CCC3C2CC1

4 rings, 18 atoms.

1,419 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H341Suspected of causing genetic defects.
Precautionary statements (9)
  • P203Obtain, read and follow all safety instructions before use.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

6beta-Hydroxycortisol suppliers

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Where suppliers are based

4 suppliers in 2 countries

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6beta-Hydroxycortisol price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • animal metabolite
  • eukaryotic metabolite
  • human metabolite
  • mammalian metabolite
  • metabolite
  • probe

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code 6beta-Hydroxycortisol is traded under.

HS 2914.40Indicative HS code

Ketone-alcohols and ketone-aldehydes

World exports in 2024
$199M
+2.5% vs 2023, imports $247M
2019 to 2024
Top exporters
  1. China29.5%
  2. Germany14.4%
  3. Netherlands12.7%
Top importers
  1. United States37.2%
  2. Netherlands8.5%
  3. Germany6.4%
Reported customs values in USD, not prices.Full trade data

The HS code shown for 6beta-Hydroxycortisol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about 6beta-Hydroxycortisol, based on the data on this page

What is 6beta-Hydroxycortisol?

6beta-hydroxycortisol is a C21-steroid that is cortisol bearing an additional hydroxy substituent at the 6beta-position.

What is the CAS number of 6beta-Hydroxycortisol?

The CAS registry number of 6beta-Hydroxycortisol is 53-35-0. Other or deprecated CAS numbers: 174866-45-6, 3078-34-0.

What is the molecular formula and weight of 6beta-Hydroxycortisol?

The molecular formula of 6beta-Hydroxycortisol is C21H30O6 and its molar mass is 378.47 g/mol.

What is 6beta-Hydroxycortisol used for?

Known uses and roles of 6beta-Hydroxycortisol include animal metabolite, eukaryotic metabolite, human metabolite, mammalian metabolite, metabolite and 1 more.

Is 6beta-Hydroxycortisol hazardous?

6beta-Hydroxycortisol carries the GHS signal word "Danger". Main hazards: harmful if swallowed, suspected of causing genetic defects. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of 6beta-Hydroxycortisol?

6beta-Hydroxycortisol is usually classified under HS code 291440 (Ketone-alcohols and ketone-aldehydes). This is indicative, confirm it with your customs broker before shipping.

Where can I buy 6beta-Hydroxycortisol?

CompoundList lists 4 suppliers of 6beta-Hydroxycortisol in China and Czech Republic. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of 6beta-Hydroxycortisol?

Suppliers quote 6beta-Hydroxycortisol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle 6beta-Hydroxycortisol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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