CompoundList
Sign in
Impurities and reference standards

Acetylfentanyl

Also known as Acetyl fentanyl, N-(1-phenethylpiperidin-4-yl)-N-phenylacetamide, N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]acetamide

CAS 3258-84-2Formula C21H26N2OMolar mass 322.45 g/molEC 642-159-4
GHS signal word: Warning. Pictograms: Harmful or irritant Prohibited, not for trade
Why it is not for trade
Acetylfentanyl chemical structure, C21H26N2O, CAS 3258-84-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
3258-84-2
Formula
C21H26N2O
Molar mass
322.45 g/mol
EC number
642-159-4
HS code
293339
Category
Impurities and reference standards

What is Acetylfentanyl?

Plain description, key identifiers and synonyms

Acetylfentanyl is a monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with acetic acid. It is a fentanyl analog that has emerged as a drug of abuse and linked to numerous deaths in North America. It has a role as an opioid analgesic and a mu-opioid receptor agonist. It is an anilide, a member of acetamides, a member of piperidines, a monocarboxylic acid amide and a tertiary amino compound.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]acetamide
CAS number
3258-84-2 CAS number cross-checked
EC number
642-159-4
Molecular formula
C21H26N2O
UNII
6DZ28538KS
InChIKey
FYIUUQUPOKIKNI-UHFFFAOYSA-N
InChI
InChI=1S/C21H26N2O/c1-18(24)23(20-10-6-3-7-11-20)21-13-16-22(17-14-21)15-12-19-8-4-2-5-9-19/h2-11,21H,12-17H2,1H3
SMILES (canonical and isomeric)
CC(=O)N(C1CCN(CC1)CCC2=CC=CC=C2)C3=CC=CC=C3

Synonyms

  • Acetyl fentanyl
  • N-(1-phenethylpiperidin-4-yl)-N-phenylacetamide
  • N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]acetamide
  • Acetamide, N-phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]-
  • Piperidine, 1-phenethyl-4-(N-phenylacetamido)-
  • N-Phenyl-N-(1-(2-phenylethyl)piperidin-4-yl)acetamide
  • Acetamide, N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)-
  • N-(1-Phenethyl-piperidin-4-yl)-N-phenyl-acetamide
  • Acetanilide, N-(1-phenethyl-4-piperidyl)-
  • Acetyl Fentanyl (1.0 mg/mL in Methanol)
  • Acetyl fentanyl-13C6 (hydrochloride)
  • Fentanyl impurity C
  • desmethyl fentanyl
  • Fentanyl specified impurity C
  • N-Phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]acetamide
  • N-(1-phenethyl-4-piperidyl)acetanilide
  • 1-Phenethyl-4-(N-phenylacetamido)piperidine
  • DEA No. 9821
  • US20230399418, Compound Acetylfentanyl
  • Fentanyl citrate impurity c
  • (N-(1-Phenethylpiperidin-4-yl)-N-phenylacetamide)
  • 1-(2-phenylethyl)-4-(N-acetylphenylamino)piperidine
  • N-Phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]acetamide #

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
322.45 g/molcalc.
Exact mass
322.2045 Dacalc.
LogP (octanol/water)
3.75calc.
Topological polar surface area
23.55 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
5calc.
Heavy atoms
24calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.38calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(CCN2CCC(Nc3ccccc3)CC2)cc1

c1ccc(CCN2CCC(Nc3ccccc3)CC2)cc1

3 rings, 21 atoms, the N-Phenyl-1-(2-phenylethyl)-4-piperidinamine ring system.

368 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (19)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Acetylfentanyl suppliers

Trading restrictions apply to this substance

Narcotic drug

Acetylfentanyl is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Single Convention on Narcotic Drugs 1961

Our policy on controlled substances

Acetylfentanyl price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

Roles

  • agonist
  • analgesic
  • mu-opioid agent
  • mu-opioid receptor agonist
  • neurotransmitter agent
  • opioid agent
  • opioid analgesic
  • opioid receptor agonist
  • pharmaceutical

Functional uses

  • Pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

Narcotic drug

Acetylfentanyl is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Single Convention on Narcotic Drugs 1961

Our policy on controlled substances

Controls

  • US DEA controlled substance or listed chemical
  • Controlled narcotic drug

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Acetylfentanyl is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Acetylfentanyl is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Acetylfentanyl, based on the data on this page

What is Acetylfentanyl?

Acetylfentanyl is a monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with acetic acid. It is a fentanyl analog that has emerged as a drug of abuse and linked to numerous deaths in North America.

What is the CAS number of Acetylfentanyl?

The CAS registry number of Acetylfentanyl is 3258-84-2.

What is the molecular formula and weight of Acetylfentanyl?

The molecular formula of Acetylfentanyl is C21H26N2O and its molar mass is 322.45 g/mol.

What is Acetylfentanyl used for?

Known uses and roles of Acetylfentanyl include analgesics and antipyretics in pharmaceuticals, agonist, analgesic, mu-opioid agent, mu-opioid receptor agonist and 5 more.

Is Acetylfentanyl hazardous?

Acetylfentanyl carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Acetylfentanyl?

Acetylfentanyl is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Can I buy Acetylfentanyl on CompoundList?

No. Acetylfentanyl is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle Acetylfentanyl

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

Explore more in Impurities and reference standards or HS code 293339

Not available for trade
Why