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Analgesics and anti-inflammatories

Fentanyl

Also known as Phentanyl, Fentanil, Fentanest

CAS 437-38-7Formula C22H28N2OMolar mass 336.48 g/molEC 207-113-6
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard Prohibited, not for trade Drug substance
Why it is not for trade
Fentanyl chemical structure, C22H28N2O, CAS 437-38-7
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals
Melting point
85.2 °C
Solubility
In water, 200 mg/L at 25 °C
HS code
293339
Category
Analgesics and anti-inflammatories

What is Fentanyl?

Plain description, key identifiers and synonyms

Fentanyl is a monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid. It has a role as an opioid analgesic, an anaesthetic, an intravenous anaesthetic, a mu-opioid receptor agonist, an anaesthesia adjuvant and an adjuvant. It is an anilide, a member of piperidines and a monocarboxylic acid amide.

Fentanyl is a synthetic piperidine opioid used as an analgesic.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
CAS number
437-38-7 CAS number cross-checkedOther or deprecated CAS: 201415-26-1
EC number
207-113-6
Molecular formula
C22H28N2O
UNII
UF599785JZ
InChIKey
PJMPHNIQZUBGLI-UHFFFAOYSA-N
InChI
InChI=1S/C22H28N2O/c1-2-22(25)24(20-11-7-4-8-12-20)21-14-17-23(18-15-21)16-13-19-9-5-3-6-10-19/h3-12,21H,2,13-18H2,1H3
SMILES (canonical and isomeric)
CCC(=O)N(C1CCN(CC1)CCC2=CC=CC=C2)C3=CC=CC=C3

Synonyms

  • Phentanyl
  • Fentanil
  • Fentanest
  • Duragesic
  • Sublimase
  • Fentanylum
  • Durogesic
  • Fentanila
  • Matrifen
  • Duragesic-100
  • Duragesic-12
  • Duragesic-25
  • Duragesic-50
  • Duragesic-75
  • Fentanyl-12
  • Fentanyl-25
  • Fentanyl-50
  • Fentanyl-75
  • Recuvyra
  • N-(1-Phenethylpiperidin-4-yl)-N-phenylpropionamide
  • Subsys
  • Fentanyl-100
  • PecFent
  • Fentanyl CII
  • effentora
Show all 39 synonyms
  • 1-Phenethyl-4-N-propionylanilinopiperidine
  • Fendrop
  • Durogesic d-trans
  • N-(1-Phenethyl-4-piperidyl)propionanilide
  • N-Phenethyl-4-(N-propionylanilino)piperidine
  • 1-Phenethyl-4-(N-phenylpropionamido)piperidine
  • N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
  • N-(1-Phenethyl-4-piperidinyl)-N-phenylpropionamide
  • Fentanilo
  • Rapinyl
  • Fentanyl Transdermal System
  • N-Phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)propanamide
  • Propionanilide, N-(1-phenethyl-4-piperidyl)-
  • En3267

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystalsexp.
Melting point
85.2 °Cexp.
Solubility
In water, 200 mg/L at 25 °Cexp.
Vapour pressure
4.43 × 10⁻⁹ mm Hg at 25 °C (estrapolated)exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
336.48 g/molcalc.
Exact mass
336.2202 Dacalc.
LogP (octanol/water)
4.14calc.
Topological polar surface area
23.55 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
6calc.
Heavy atoms
25calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.41calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(CCN2CCC(Nc3ccccc3)CC2)cc1

c1ccc(CCN2CCC(Nc3ccccc3)CC2)cc1

3 rings, 21 atoms, the N-Phenyl-1-(2-phenylethyl)-4-piperidinamine ring system.

368 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H300Fatal if swallowed.
  • H310Fatal in contact with skin.
  • H317May cause an allergic skin reaction.
  • H330Fatal if inhaled.
  • H334May cause allergy or asthma symptoms or breathing difficulties if inhaled.
  • H361Suspected of damaging fertility or the unborn child.
  • H362May cause harm to breast-fed children.
  • H413May cause long lasting harmful effects to aquatic life.
Precautionary statements (29)
  • P203Obtain, read and follow all safety instructions before use.
  • P233Keep container tightly closed.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P262Do not get in eyes, on skin, or on clothing.
  • P263Avoid contact during pregnancy and while nursing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P316Get emergency medical help immediately.
  • P318If exposed or concerned, get medical advice.
  • P320Specific treatment is urgent (see supplemental first aid instructions on the label).
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P342 + P316If experiencing respiratory symptoms: Get emergency medical help immediately.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403Store in a well-ventilated place.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Fentanyl suppliers

Trading restrictions apply to this substance

Narcotic drug

Fentanyl is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Single Convention on Narcotic Drugs 1961

Our policy on controlled substances

Fentanyl price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

Fentanyl (DEA Code Number: 9801) is a Schedule II controlled substance.

Schedule II Controlled Substance: (A) The drug or other substance has a high potential for abuse, (B) The drug or other substance has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions, and (C) Abuse of the drug or other substances may lead to severe psychological or physical dependence.

Analgesics, Opioid, Adjuvants, Anesthesia, Narcotics, Anesthetics, Intravenous.

Veterinary medication:.

Fentanyl is a synthetic, lipophilic opioid agonist with analgesic and anesthetic properties. Fentanyl selectively binds to and activates the mu-receptor in the central nervous system (CNS) thereby mimicking the effects of endogenous opiates. Fentanyl is commonly used to treat chronic cancer pain or in anesthesia.

Read more

It is related to other opioids like morphine and oxycodone. Fentanyl is a DEA Schedule II controlled substance. Substances in the DEA Schedule II have a high potential for abuse which may lead to severe psychological or physical dependence.”.

Use classes: Pharmaceuticals, Nervous System, Animal Drugs.

Pharmacological actions

  • Adjuvants, Anesthesia
  • Analgesics, Opioid
  • Anesthetics, Intravenous
  • Narcotics

Roles

  • adjuvant
  • agonist
  • anaesthesia adjuvant
  • anaesthetic
  • analgesic
  • anti-inflammatory agent
  • anti-obesity agent
  • antimicrobial agent
  • antineoplastic agent
  • antispasmodic drug
  • antiviral agent
  • general anaesthetic
  • intravenous anaesthetic
  • mu-opioid agent
  • mu-opioid receptor agonist
  • muscle relaxant
  • neuromuscular agent
  • neuroprotective agent
  • neurotransmitter agent
  • opioid agent
  • opioid analgesic
  • opioid receptor agonist
  • pharmaceutical
  • protective agent

Functional uses

  • Pharmaceutical

Pharmacology

Fentanyl is an Opioid Agonist. The mechanism of action of fentanyl is as a Full Opioid Agonist.

How it is made

One method consists of condensing propionyl chloride with N-(4-piperidyl)aniline, then treating the resulting N-(4-piperidyl)propionanilide with phenethyl chloride, aiding each condensation by the presence of a suitable dehydrochlorinating agent. Reaction of the base with an equimolar portion of citric acid yields the (1:1) citrate. (Fentanyl citrate)

Preparation: P.A.J. Janssen, France patent 1344366, idem, United States of America patent 3164600 (1963, 1965 both to Janssen)

Regulatory status

Inventories, regulations and trade controls that list this substance

Narcotic drug

Fentanyl is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Single Convention on Narcotic Drugs 1961

Our policy on controlled substances

Controls

  • US DEA controlled substance or listed chemical
  • Controlled narcotic drug

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Fentanyl is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Fentanyl is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Fentanyl, based on the data on this page

What is Fentanyl?

Fentanyl is a monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.

What is the CAS number of Fentanyl?

The CAS registry number of Fentanyl is 437-38-7. Other or deprecated CAS numbers: 201415-26-1.

What is the molecular formula and weight of Fentanyl?

The molecular formula of Fentanyl is C22H28N2O and its molar mass is 336.48 g/mol.

What is Fentanyl used for?

Fentanyl (DEA Code Number: 9801) is a Schedule II controlled substance. Schedule II Controlled Substance: (A) The drug or other substance has a high potential for abuse, (B) The drug or other substance has a currently accepted medical use in treatment in the United States or a currently accepted medical use with sever…

Is Fentanyl hazardous?

Fentanyl carries the GHS signal word "Danger". Main hazards: fatal if swallowed, fatal in contact with skin, may cause an allergic skin reaction. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Fentanyl?

Fentanyl is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Can I buy Fentanyl on CompoundList?

No. Fentanyl is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle Fentanyl

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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