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Screening compounds

Actb-1003

Also known as ONC201MMKI EOC317, EOC 317, Multi-mode Kinase Inhibitor EOC317

CAS 939805-30-8Formula C27H26F5N7O3Molar mass 591.54 g/mol
1 supplier listed
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Actb-1003 chemical structure, C27H26F5N7O3, CAS 939805-30-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
939805-30-8
Formula
C27H26F5N7O3
Molar mass
591.54 g/mol
HS code
293499
Category
Screening compounds

What is Actb-1003?

Plain description, key identifiers and synonyms

Multi-mode Kinase Inhibitor EOC317 is an orally available, small molecule, multi-mode kinase inhibitor (MMKI), with potential antineoplastic activity. Upon oral administration, MMKI EOC317 targets, binds to and inhibits the activity of a variety of kinases, such as phosphatidylinositol 3 kinase (PI3K), and the receptor tyrosine kinases, fibroblast growth factor receptor (FGFR), angiopoietin-1 receptor (TIE 2), and vascular endothelial growth factor receptor-2 (VEGFR-2). This inhibition may result in an induction of apoptosis of susceptible tumors cells in which these kinases are overexpressed.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-[4-[4-amino-6-(methoxymethyl)-7-(morpholin-4-ylmethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2-fluorophenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea
CAS number
939805-30-8
Molecular formula
C27H26F5N7O3
UNII
44750KD9OE
MDL number
MFCD25976782
InChIKey
GZPJCJKUZPUFAL-UHFFFAOYSA-N
InChI
InChI=1S/C27H26F5N7O3/c1-41-13-17-22(12-38-6-8-42-9-7-38)39-24(25(33)34-14-35-39)23(17)15-2-5-20(19(29)10-15)36-26(40)37-21-11-16(27(30,31)32)3-4-18(21)28/h2-5,10-11,14H,6-9,12-13H2,1H3,(H2,33,34,35)(H2,36,37,40)
SMILES (canonical and isomeric)
COCC1=C(N2C(=C1C3=CC(=C(C=C3)NC(=O)NC4=C(C=CC(=C4)C(F)(F)F)F)F)C(=NC=N2)N)CN5CCOCC5

Synonyms

  • ONC201MMKI EOC317
  • EOC 317
  • Multi-mode Kinase Inhibitor EOC317
  • 1-(4-(4-amino-6-(methoxymethyl)-7-(morpholinomethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl)-2-fluorophenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea
  • Urea, N-(4-(4-amino-6-(methoxymethyl)-7-(4-morpholinylmethyl)pyrrolo(2,1-F)(1,2,4)triazin-5-yl)-2-fluorophenyl)-N'-(2-fluoro-5-(trifluoromethyl)phenyl)-
  • N-[4-[4-amino-6-(methoxymethyl)-7-(4-morpholinylmethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2-fluorophenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]urea
  • 1-[4-[4-amino-6-(methoxymethyl)-7-(morpholin-4-ylmethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2-fluorophenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea
  • ACTB-1003?
  • 1-[4-[4-amino-6-(methoxymethyl)-7-(morpholinomethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2-fluoro-phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea
  • 1-{4-[4-Amino-6-(methoxymethyl)-7-(4-morpholinylmethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2-fluorophenyl}-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
591.54 g/molcalc.
Exact mass
591.2017 Dacalc.
LogP (octanol/water)
4.9calc.
Topological polar surface area
119 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
7calc.
Heavy atoms
42calc.
Rings
5calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.3calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(Nc1ccccc1)Nc1ccc(-c2cc(CN3CCOCC3)n3ncncc23)cc1

O=C(Nc1ccccc1)Nc1ccc(-c2cc(CN3CCOCC3)n3ncncc23)cc1

5 rings, 32 atoms.

No other chemical in our database has this scaffold.

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Actb-1003 suppliers

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Where suppliers are based

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Actb-1003 price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Actb-1003 is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Actb-1003 is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Actb-1003, based on the data on this page

What is Actb-1003?

Multi-mode Kinase Inhibitor EOC317 is an orally available, small molecule, multi-mode kinase inhibitor (MMKI), with potential antineoplastic activity.

What is the CAS number of Actb-1003?

The CAS registry number of Actb-1003 is 939805-30-8.

What is the molecular formula and weight of Actb-1003?

The molecular formula of Actb-1003 is C27H26F5N7O3 and its molar mass is 591.54 g/mol.

What is Actb-1003 used for?

Known uses and roles of Actb-1003 include building blocks in research and laboratory and screening compounds in research and laboratory.

Is Actb-1003 hazardous?

No GHS hazard classification for Actb-1003 is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Actb-1003?

Actb-1003 is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Actb-1003?

CompoundList lists 1 supplier of Actb-1003 in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Actb-1003?

Suppliers quote Actb-1003 on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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