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Analgesics and anti-inflammatories

Adapalene

Also known as Differin, Adaferin, Adapaleno

CAS 106685-40-9Formula C28H28O3Molar mass 412.53 g/molEC 620-513-9
GHS signal word: Warning. Pictograms: Harmful or irritant, Serious health hazard 186 suppliers listed Drug substance
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Adapalene chemical structure, C28H28O3, CAS 106685-40-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
106685-40-9
Formula
C28H28O3
Molar mass
412.53 g/mol
EC number
620-513-9
HS code
291899
Category
Analgesics and anti-inflammatories

What is Adapalene?

Plain description, key identifiers and synonyms

Adapalene is a naphthoic acid that is CD437 in which the phenolic hydroxy group has been converted to its methyl ether. It has a role as a non-steroidal anti-inflammatory drug, a dermatologic drug and an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor. It is a monocarboxylic acid, a naphthoic acid and a member of adamantanes. It is functionally related to a CD437.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid
CAS number
106685-40-9 CAS number cross-checked
EC number
620-513-9
Molecular formula
C28H28O3
UNII
1L4806J2QF
MDL number
MFCD03106112
InChIKey
LZCDAPDGXCYOEH-UHFFFAOYSA-N
InChI
InChI=1S/C28H28O3/c1-31-26-7-6-23(21-2-3-22-12-24(27(29)30)5-4-20(22)11-21)13-25(26)28-14-17-8-18(15-28)10-19(9-17)16-28/h2-7,11-13,17-19H,8-10,14-16H2,1H3,(H,29,30)
SMILES (canonical and isomeric)
COC1=C(C=C(C=C1)C2=CC3=C(C=C2)C=C(C=C3)C(=O)O)C45CC6CC(C4)CC(C6)C5

Synonyms

  • Differin
  • Adaferin
  • Adapaleno
  • Adapalenum
  • Differine
  • CD 271
  • 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid
  • 6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic acid
  • 6-(4-Methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid
  • 6-[3-(adamantan-1-yl)-4-methoxyphenyl]naphthalene-2-carboxylic acid
  • IDP-126 Component Adapalene
  • Cabtreo component adapalene
  • 2-Naphthalenecarboxylic acid, 6-(4-methoxy-3-tricyclo(3.3.1.1(sup 3,7))dec-1-ylphenyl)-
  • Adaplaene
  • Effaclar
  • Adapalene Gel
  • 6-(3-(adamantan-1-yl)-4-methoxyphenyl)naphthalene-2-carboxylic acid
  • Proactiv MD Kit
  • 6-(4-Methoxy-3-tricyclo(3.3.1.13,7)dec-1-ylphenyl)-2-naphthalenecarboxylic Acid
  • Curist Acne Relief
  • MD Kit
  • Adaplane 0.1%
  • Proactiv MD Adapalene
  • Adapalene Gel 0.1%
  • Adapalene Topical Solution
Show all 36 synonyms
  • Adapalene Gel USP, 0.3%
  • Proactiv MD Adapalene Acne Treatment
  • 271, CD
  • Neutrogena Adapalene 0.1% Acne Treatment
  • 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid
  • 6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid
  • 6-[3-(1-adamantyl)-4-methoxy-phenyl]naphthalene-2-carboxylic acid
  • 6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid
  • Adapaleno (INN-Spanish)
  • Adapalen
  • Differin Gel

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
412.53 g/molcalc.
Exact mass
412.2038 Dacalc.
LogP (octanol/water)
6.68calc.
Topological polar surface area
46.53 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
4calc.
Heavy atoms
31calc.
Rings
7calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.39calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1cc(-c2ccc3ccccc3c2)cc(C23CC4CC(CC(C4)C2)C3)c1

c1cc(-c2ccc3ccccc3c2)cc(C23CC4CC(CC(C4)C2)C3)c1

7 rings, 26 atoms.

12 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H317May cause an allergic skin reaction.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
  • H361Suspected of damaging fertility or the unborn child.
Precautionary statements (23)
  • P203Obtain, read and follow all safety instructions before use.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Adapalene suppliers

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All 186 suppliers
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Where suppliers are based

186 suppliers in 29 countries

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Adapalene price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Anti-Inflammatory Agents, Non-Steroidal
  • Dermatologic Agents

Roles

  • anti-inflammatory agent
  • anti-inflammatory drug
  • antirheumatic drug
  • dermatologic drug
  • enzyme inhibitor
  • non-steroidal anti-inflammatory drug
  • pharmaceutical
  • protein kinase inhibitor

Pharmacology

Adapalene is a topical retinoid-like compound, chemically similar to vitamin A. Although the exact mechanism of action is unknown, adapalene binds to specific retinoic acid receptors in the nucleus, leading to specific gene expression. This agent stimulates skin growth through modulation of cellular differentiation, inflammatory processes and keratinization of follicular epithelial cells. Adapalene may increase dermal sensitivity to ultraviolet radiation. (NCI04)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Adapalene is traded under.

HS 2918.99Indicative HS code

Carboxylic acids, with additional oxygen function (not alcohol, phenol, aldehyde or ketone)…

World exports in 2024
$1.46B
−1.1% vs 2023, imports $1.54B
2019 to 2024
Top exporters
  1. China40.0%
  2. India * partner reported26.6%
  3. Germany8.0%
Top importers
  1. United States25.6%
  2. Brazil6.7%
  3. Argentina5.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Adapalene is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Adapalene, based on the data on this page

What is Adapalene?

Adapalene is a naphthoic acid that is CD437 in which the phenolic hydroxy group has been converted to its methyl ether. It has a role as a non-steroidal anti-inflammatory drug, a dermatologic drug and an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor.

What is the CAS number of Adapalene?

The CAS registry number of Adapalene is 106685-40-9.

What is the molecular formula and weight of Adapalene?

The molecular formula of Adapalene is C28H28O3 and its molar mass is 412.53 g/mol.

What is Adapalene used for?

Known uses and roles of Adapalene include anti-inflammatories in pharmaceuticals, anti-inflammatory agent, anti-inflammatory drug, antirheumatic drug, dermatologic drug and 6 more.

Is Adapalene hazardous?

Adapalene carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes skin irritation, may cause an allergic skin reaction. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Adapalene?

Adapalene is usually classified under HS code 291899 (Carboxylic acids with additional oxygen function and their anhydrides, halides…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Adapalene?

CompoundList lists 186 suppliers of Adapalene in China, India, United States, Germany and 25 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Adapalene in India?

40 suppliers in India list Adapalene on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Adapalene?

Suppliers quote Adapalene on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Adapalene

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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