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Nucleosides and nucleotides

Adenosylcobalamin

Also known as coenzyme B-12, Cobamamide, Cobamide coenzyme

Formula C72H100CoN18O17P-3Molar mass 1,579.61 g/mol
5 suppliers listed
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Adenosylcobalamin chemical structure, C72H100CoN18O17P-3
2D chemical structure

Key facts

What buyers check first

All properties
Formula
C72H100CoN18O17P-3
Molar mass
1,579.61 g/mol
HS code
293626
Category
Nucleosides and nucleotides

What is Adenosylcobalamin?

Plain description, key identifiers and synonyms

Cobamamide is a member of the class of cobalamins that is vitamin B12 in which the cyano group is replaced by a 5'-deoxyadenos-5'-yl moiety. It is one of the two metabolically active form of vitamin B12. It has a role as a coenzyme, a cofactor, a prosthetic group, an Escherichia coli metabolite and a human metabolite. It is a member of cobalamins and a corrinoid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-methanidyloxolane-3,4-diol, cobalt, [(2R,3S,4R,5S)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2R)-1-[3-[(1R,2R,3R,4Z,7S,9Z,12S,13S,14Z,17S,18S,19R)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-21-id-3-yl]propanoylamino]propan-2-yl] phosphate
Molecular formula
C72H100CoN18O17P-3
INCI name
COBAMAMIDE
InChIKey
DFDCDQDATCDZSO-OUCXYWSSSA-L
InChI
InChI=1S/C62H90N13O14P.C10H12N5O3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);2-4,6-7,10,16-17H,1H2,(H2,11,12,13);/q;-1;/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57+,59-,60+,61+,62+;4-,6-,7-,10-;/m11./s1
Canonical SMILES
CC1=C2N=C(C=C3N=C(C(C)=C4[N-]C(C(CC(N)=O)C4(C)CCC(=O)NCC(C)OP(=O)([O-])OC4C(CO)OC(n5cnc6cc(C)c(C)cc65)C4O)C4(C)N=C1C(CCC(N)=O)C4(C)CC(N)=O)C(CCC(N)=O)C3(C)C)C(CCC(N)=O)C2(C)CC(N)=O.[CH2-]C1OC(n2cnc3c(N)ncnc32)C(O)C1O.[Co]
Isomeric SMILES
CC1=CC2=C(C=C1C)N(C=N2)[C@@H]3[C@@H]([C@@H]([C@H](O3)CO)OP(=O)([O-])O[C@H](C)CNC(=O)CC[C@@]\4([C@H]([C@@H]5[C@]6([C@@]([C@@H](C(=N6)/C(=C\7/[C@@]([C@@H](C(=N7)/C=C\8/C([C@@H](C(=N8)/C(=C4\[N-]5)/C)CCC(=O)N)(C)C)CCC(=O)N)(C)CC(=O)N)/C)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[CH2-][C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)O.[Co]

Synonyms

  • coenzyme B-12
  • Cobamamide
  • Cobamide coenzyme
  • Calomide
  • Adenosylcob(III)alamin
  • Cobamamid
  • Vitamin B12 coenzyme
  • 5'-Deoxy-5'-adenosylcobalamin
  • Cobalamin coenzyme
  • Cobamamida
  • Cobamamidum
  • Dibencozide
  • Funacomide
  • AdoCbl
  • DBC coenzyme
  • (5,6-dimethylbenzimidazolyl)cobamide coenzyme
  • Deoxyadenosylcobalamin
  • 5'-Deoxyadenosyl vitamin B12
  • 5'-Deoxyadenosylcobalamin
  • (5'-Deoxy-5'-adenosyl)cobamide coenzyme
  • 5'-Deoxy-5'-adenosyl vitamin B12
  • Vitamin B12 coenzymes
  • 5'-Deoxyadenosyl-5,6-dimethylbenzimidazolylcobamide
  • Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-adenosylcobamide
  • Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-(5'-deoxy-5'-adenosyl)cobamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
1,579.61 g/molcalc.
Exact mass
1,578.66 Dacalc.
LogP (octanol/water)
2.17calc.
Topological polar surface area
584.2 Ųcalc.
Hydrogen bond donors
12calc.
Hydrogen bond acceptors
25calc.
Rotatable bonds
27calc.
Heavy atoms
109calc.
Rings
11calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.6calc.
Formal charge
-3calc.
Stereocentres
19calc.
Components
3calc.
Lipinski rule of five
Fails (3 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(CCC1CC2NC1=CC1=NC(=CC3=NC(=CC4=NC2CC4)CC3)CC1)NCCO[PH](=O)OC1COC(n2cnc3ccccc32)C1

O=C(CCC1CC2NC1=CC1=NC(=CC3=NC(=CC4=NC2CC4)CC3)CC1)NCCO[PH](=O)OC1COC(n2cnc3ccccc32)C1

8 rings, 48 atoms.

158 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Adenosylcobalamin suppliers

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All 5 suppliers
5 of 5 offers

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Where suppliers are based

5 suppliers in 2 countries

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Adenosylcobalamin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name COBAMAMIDE(antioxidant, skin conditioning, skin protecting)

Roles

  • Escherichia coli metabolite
  • animal metabolite
  • anti-anaemic agent
  • bacterial metabolite
  • coenzyme
  • cofactor
  • dermatologic drug
  • eukaryotic metabolite
  • human metabolite
  • mammalian metabolite
  • metabolite
  • pharmaceutical
  • prokaryotic metabolite
  • prosthetic group

Cosmetic functions

  • Antioxidant
  • Skin conditioning
  • Skin protecting

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Adenosylcobalamin is traded under.

HS 2936.26Indicative HS code

Vitamin B12 and its derivatives

World exports in 2024
$306M
+16.8% vs 2023, imports $308M
2019 to 2024
Top exporters
  1. China47.1%
  2. France * partner reported12.0%
  3. United States10.1%
Top importers
  1. United States23.0%
  2. India * partner reported9.8%
  3. Netherlands7.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Adenosylcobalamin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Adenosylcobalamin, based on the data on this page

What is Adenosylcobalamin?

Cobamamide is a member of the class of cobalamins that is vitamin B12 in which the cyano group is replaced by a 5'-deoxyadenos-5'-yl moiety. It is one of the two metabolically active form of vitamin B12. It has a role as a coenzyme, a cofactor, a prosthetic group, an Escherichia coli metabolite and a human metabolite.

What is the molecular formula and weight of Adenosylcobalamin?

The molecular formula of Adenosylcobalamin is C72H100CoN18O17P-3 and its molar mass is 1,579.61 g/mol.

What is Adenosylcobalamin used for?

Known uses and roles of Adenosylcobalamin include vitamins and supplements in pharmaceuticals, antioxidants in cosmetics and personal care, skin conditioning agents in cosmetics and personal care, vitamins, minerals and nutrients in food and beverage, feed vitamins in animal feed and nutrition and 17 more.

Is Adenosylcobalamin hazardous?

No GHS hazard classification for Adenosylcobalamin is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Adenosylcobalamin?

Adenosylcobalamin is usually classified under HS code 293626 (Vitamin B12 and its derivatives). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Adenosylcobalamin?

CompoundList lists 5 suppliers of Adenosylcobalamin in India and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Adenosylcobalamin in India?

3 suppliers in India list Adenosylcobalamin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Adenosylcobalamin?

Suppliers quote Adenosylcobalamin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Adenosylcobalamin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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