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Advantame

Also known as Advantame monohydrate, (S)-3-((3-(3-Hydroxy-4-methoxyphenyl)propyl)amino)-4-(((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)amino)-4-oxobutanoic acid hydrate, L-Phenylalanine, N-(3-(3-hydroxy-4-methoxyphenyl)propyl)-l-alpha-aspartyl-, 2-methyl ester, hydrate (1:1)

CAS 714229-20-6Formula C24H32N2O8Molar mass 476.53 g/mol
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Advantame chemical structure, C24H32N2O8, CAS 714229-20-6
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
714229-20-6
Formula
C24H32N2O8
Molar mass
476.53 g/mol
HS code
292429
Category
Peptides

What is Advantame?

Plain description, key identifiers and synonyms

Advantame is a chemical substance with the molecular formula C24H32N2O8 and a molar mass of 476.53 g/mol. Its CAS registry number is 714229-20-6. The IUPAC name is (3S)-3-[3-(3-hydroxy-4-methoxyphenyl)propylamino]-4-[[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid, hydrate.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(3S)-3-[3-(3-hydroxy-4-methoxyphenyl)propylamino]-4-[[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid, hydrate
CAS number
714229-20-6 CAS number cross-checked
Molecular formula
C24H32N2O8
UNII
3ZA6810AWX
MDL number
MFCD28144745
InChIKey
NQQIEOGMDRFTDZ-HLRBRJAUSA-N
InChI
InChI=1S/C24H30N2O7.H2O/c1-32-21-11-10-17(14-20(21)27)9-6-12-25-18(15-22(28)29)23(30)26-19(24(31)33-2)13-16-7-4-3-5-8-16;/h3-5,7-8,10-11,14,18-19,25,27H,6,9,12-13,15H2,1-2H3,(H,26,30)(H,28,29);1H2/t18-,19-;/m0./s1
Canonical SMILES
COC(=O)C(Cc1ccccc1)NC(=O)C(CC(=O)O)NCCCc1ccc(OC)c(O)c1.O
Isomeric SMILES
COC1=C(C=C(C=C1)CCCN[C@@H](CC(=O)O)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)OC)O.O

Synonyms

  • Advantame monohydrate
  • (S)-3-((3-(3-Hydroxy-4-methoxyphenyl)propyl)amino)-4-(((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)amino)-4-oxobutanoic acid hydrate
  • L-Phenylalanine, N-(3-(3-hydroxy-4-methoxyphenyl)propyl)-l-alpha-aspartyl-, 2-methyl ester, hydrate (1:1)
  • L-Phenylalanine, N-(3-(3-hydroxy-4-methoxyphenyl)propyl)-l-alpha-aspartyl-, 2-methyl ester, monohydrate
  • Phenylalanine, N-(3-(3-hydroxy-4-methoxyphenyl)propyl)-alpha-aspartyl-, 2-methyl ester, monohydrate
  • advantame hydrate
  • INS NO.969
  • (3S)-4-[[(2S)-1-methoxy-1-oxidanylidene-3-phenyl-propan-2-yl]amino]-3-[3-(4-methoxy-3-oxidanyl-phenyl)propylamino]-4-oxidanylidene-butanoic acid, hydrate
  • 4-Hydroxy-3-{[3-(3-hydroxy-4-methoxyphenyl)propyl]amino}-4-[(1-methoxy-1-oxo-3-phenylpropan-2-yl)imino]butanoic acid--water (1/1)
  • Methyl N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-L-alpha-aspartyl-L-phenylalaninate--water (1/1)
  • N-(N-(3-(3-Hydroxy-4-methoxyphenyl) propyl)-l-alpha-aspartyl)-l-phenylalanine-1-methyl ester, monohydrate

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
476.53 g/molcalc.
Exact mass
476.2159 Dacalc.
LogP (octanol/water)
0.84calc.
Topological polar surface area
165.7 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
13calc.
Heavy atoms
34calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.38calc.
Formal charge
0calc.
Stereocentres
2calc.
Components
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(CNCCCc1ccccc1)NCCc1ccccc1

O=C(CNCCCc1ccccc1)NCCc1ccccc1

2 rings, 22 atoms.

6 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Advantame suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 5 suppliers
5 of 5 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

5 suppliers in 2 countries

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Advantame price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Functional uses

  • Flavouring and nutrient

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Advantame is traded under.

HS 2924.29Indicative HS code

Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other

World exports in 2024
$5.69B
−5.1% vs 2023, imports $5.8B
2019 to 2024
Top exporters
  1. China32.3%
  2. Switzerland * partner reported13.6%
  3. Norway * partner reported12.8%
Top importers
  1. United States15.9%
  2. Ireland15.8%
  3. Germany11.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Advantame is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Advantame, based on the data on this page

What is Advantame?

Advantame is a chemical substance with the molecular formula C24H32N2O8 and a molar mass of 476.53 g/mol. Its CAS registry number is 714229-20-6. The IUPAC name is (3S)-3-[3-(3-hydroxy-4-methoxyphenyl)propylamino]-4-[[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid, hydrate.

What is the CAS number of Advantame?

The CAS registry number of Advantame is 714229-20-6.

What is the molecular formula and weight of Advantame?

The molecular formula of Advantame is C24H32N2O8 and its molar mass is 476.53 g/mol.

What is Advantame used for?

Known uses and roles of Advantame include sweeteners in food and beverage and flavouring and nutrient.

Is Advantame hazardous?

No GHS hazard classification for Advantame is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Advantame?

Advantame is usually classified under HS code 292429 (Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Advantame?

CompoundList lists 5 suppliers of Advantame in China and India. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Advantame in India?

1 supplier in India list Advantame on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Advantame?

Suppliers quote Advantame on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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