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Screening compounds

AG 556

Also known as Tyrphostin B56, Tyrphostin AG556, ag556

CAS 149092-35-3Formula C20H20N2O3Molar mass 336.39 g/mol
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AG 556 chemical structure, C20H20N2O3, CAS 149092-35-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
149092-35-3
Formula
C20H20N2O3
Molar mass
336.39 g/mol
HS code
292690
Category
Screening compounds

What is AG 556?

Plain description, key identifiers and synonyms

Tyrphostin B56 is a member of the tyrphostin family of tyrosine kinase inhibitors, that selectively inhibits epidermal growth factor receptor kinase activity. (NCI)

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)prop-2-enamide
CAS number
149092-35-3Other or deprecated CAS: 133550-41-1
Molecular formula
C20H20N2O3
MDL number
MFCD00209860
InChIKey
GWCNJMUSWLTSCW-SFQUDFHCSA-N
InChI
InChI=1S/C20H20N2O3/c21-14-17(12-16-9-10-18(23)19(24)13-16)20(25)22-11-5-4-8-15-6-2-1-3-7-15/h1-3,6-7,9-10,12-13,23-24H,4-5,8,11H2,(H,22,25)/b17-12+
Canonical SMILES
N#CC(=Cc1ccc(O)c(O)c1)C(=O)NCCCCc1ccccc1
Isomeric SMILES
C1=CC=C(C=C1)CCCCNC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N

Synonyms

  • Tyrphostin B56
  • Tyrphostin AG556
  • ag556
  • alpha-Cyano-(3,4-dihydroxy)-N-(4-phenylbutyl)cinnamide
  • N-(4-Phenylbutyl)-3,4-dihydroxybenzylidene cyanoacetamide
  • (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)prop-2-enamide
  • (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)acrylamide
  • 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)acrylamide
  • (E)-AG 556
  • 2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)-
  • Tocris-0616
  • Tyrphostin deriv. 56
  • HSCI1_000058
  • (2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)prop-2-enamide
  • AG 556, >98%

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
336.39 g/molcalc.
Exact mass
336.1474 Dacalc.
LogP (octanol/water)
3.14calc.
Topological polar surface area
93.35 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
7calc.
Heavy atoms
25calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.2calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(C=Cc1ccccc1)NCCCCc1ccccc1

O=C(C=Cc1ccccc1)NCCCCc1ccccc1

2 rings, 21 atoms, the 2-Propenamide, 3-phenyl-N-(4-phenylbutyl)-, (2E)- ring system.

5 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

AG 556 suppliers

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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

1 supplier in 1 country

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AG 556 price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code AG 556 is traded under.

HS 2926.90Indicative HS code

Nitrile-function compounds, other

World exports in 2024
$2.15B
−13.5% vs 2023, imports $2.17B
2019 to 2024
Top exporters
  1. China35.6%
  2. France * partner reported12.7%
  3. India * partner reported11.2%
Top importers
  1. United States13.6%
  2. China12.4%
  3. Brazil11.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for AG 556 is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about AG 556, based on the data on this page

What is AG 556?

Tyrphostin B56 is a member of the tyrphostin family of tyrosine kinase inhibitors, that selectively inhibits epidermal growth factor receptor kinase activity. (NCI)

What is the CAS number of AG 556?

The CAS registry number of AG 556 is 149092-35-3. Other or deprecated CAS numbers: 133550-41-1.

What is the molecular formula and weight of AG 556?

The molecular formula of AG 556 is C20H20N2O3 and its molar mass is 336.39 g/mol.

What is AG 556 used for?

Known uses and roles of AG 556 include building blocks in research and laboratory and screening compounds in research and laboratory.

Is AG 556 hazardous?

No GHS hazard classification for AG 556 is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of AG 556?

AG 556 is usually classified under HS code 292690 (Nitrile-function compounds, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy AG 556?

CompoundList lists 1 supplier of AG 556 in United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of AG 556?

Suppliers quote AG 556 on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle AG 556

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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