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Alpha-msh

Also known as Alpha msh, alpha Intermedin, Intermedin, alpha

CAS 581-05-5Formula C77H109N21O19SMolar mass 1,664.91 g/mol
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Alpha-msh chemical structure, C77H109N21O19S, CAS 581-05-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
581-05-5
Formula
C77H109N21O19S
Molar mass
1,664.91 g/mol
HS code
293329
Category
Peptides

What is Alpha-msh?

Plain description, key identifiers and synonyms

Alpha-melanocyte stimulating hormone is a thirteen amino acid peptide hormone consisting of N-acetyl-L-Ser, L-Tyr, L-Ser, L-Met, L-Glu, L-His, L-Phe, L-Arg, L-Trp, Gly, L-Lys, L-Pro and L-valinamide units joined in sequence by peptide linkages. It is an endogenous melanocortin receptor agonist that exhibits anti-inflammatory activity. It has a role as an anti-inflammatory agent.

Alpha-msh is a peptide hormone in Homo sapiens.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-6-amino-1-[(2S)-2-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
CAS number
581-05-5
Molecular formula
C77H109N21O19S
UNII
OVF025LA77
InChIKey
WHNFPRLDDSXQCL-UAZQEYIDSA-N
InChI
InChI=1S/C77H109N21O19S/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(108)51(19-12-29-83-77(80)81)89-70(111)55(32-44-14-6-5-7-15-44)92-72(113)58(35-47-37-82-41-86-47)95-68(109)52(25-26-63(104)105)90-69(110)53(27-31-118-4)91-74(115)60(40-100)96-71(112)56(33-45-21-23-48(102)24-22-45)93-73(114)59(39-99)87-43(3)101/h5-9,14-17,21-24,36-37,41-42,51-61,64,84,99-100,102H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H2,79,106)(H,82,86)(H,85,107)(H,87,101)(H,88,103)(H,89,111)(H,90,110)(H,91,115)(H,92,113)(H,93,114)(H,94,108)(H,95,109)(H,96,112)(H,97,116)(H,104,105)(H4,80,81,83)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1
Canonical SMILES
CSCCC(NC(=O)C(CO)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(C)=O)C(=O)NC(CCC(=O)O)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCC(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(C(N)=O)C(C)C
Isomeric SMILES
CC(C)[C@@H](C(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC2=CNC3=CC=CC=C32)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CC5=CNC=N5)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CC6=CC=C(C=C6)O)NC(=O)[C@H](CO)NC(=O)C

Synonyms

  • Alpha msh
  • alpha Intermedin
  • Intermedin, alpha
  • MSH, alpha
  • MSH, Des-Acetyl
  • Desacetyl alpha MSH
  • Desacetyl alpha-MSH
  • (Desacetyl)alpha-MSH
  • alpha-MSH, Desacetyl
  • a-Melanotropin (swine)
  • alpha-melanotropin
  • alpha-melanotropin (ox)
  • alpha-melanotropin (human)
  • alpha-melanotropin (sheep)
  • alpha-Melanotropin (pig)
  • alpha-Melanotropin (swine)
  • alpha-Intermedin
  • Intermedine
  • Ba 33761
  • alpha-Melanotropin (Macaca nemestrina)
  • alpha-Melanotropin I (Oncorhynchus keta)
  • alpha-1-13-Corticotropin, N-acetyl-13-L-valinamide-
  • Ac-L-Ser-L-Tyr-L-Ser-L-Met-L-Glu-L-His-L-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-Val-NH2
  • N-Ac-L-Ser-L-Tyr-L-Ser-L-Met-L-Glu-L-His-L-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-Val-NH2
  • L-Valinamide, N-acetyl-L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-
Show all 26 synonyms
  • N-acetyl-L-Ser-L-Tyr-L-Ser-L-Met-L-alpha-Glu-L-His-L-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-valinamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
1,664.91 g/molcalc.
Exact mass
1,663.7929 Dacalc.
LogP (octanol/water)
-4.54calc.
Topological polar surface area
643 Ųcalc.
Hydrogen bond donors
23calc.
Hydrogen bond acceptors
22calc.
Rotatable bonds
50calc.
Heavy atoms
118calc.
Rings
6calc.
Aromatic rings
5calc.
Fraction sp3 carbons
0.49calc.
Formal charge
0calc.
Stereocentres
12calc.
Lipinski rule of five
Fails (3 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(CCc1ccccc1)NCC(=O)NCC(=O)NCC(=O)NC(Cc1c[nH]cn1)C(=O)NC(Cc1ccccc1)C(=O)NCC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCC(=O)NCC(=O)N1CCCC1

O=C(CCc1ccccc1)NCC(=O)NCC(=O)NCC(=O)NC(Cc1c[nH]cn1)C(=O)NC(Cc1ccccc1)C(=O)NCC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCC(=O)NCC(=O)N1CCCC1

6 rings, 74 atoms.

29 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Alpha-msh suppliers

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Where suppliers are based

4 suppliers in 2 countries

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Alpha-msh price

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Hormones

Roles

  • anti-inflammatory agent

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Alpha-msh is traded under.

HS 2933.29Indicative HS code

Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the…

World exports in 2024
$1.43B
−7.6% vs 2023, imports $1.47B
2019 to 2024
Top exporters
  1. China28.1%
  2. France * partner reported12.7%
  3. India * partner reported10.3%
Top importers
  1. United Kingdom13.0%
  2. United States7.9%
  3. China6.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Alpha-msh is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Alpha-msh, based on the data on this page

What is Alpha-msh?

Alpha-melanocyte stimulating hormone is a thirteen amino acid peptide hormone consisting of N-acetyl-L-Ser, L-Tyr, L-Ser, L-Met, L-Glu, L-His, L-Phe, L-Arg, L-Trp, Gly, L-Lys, L-Pro and L-valinamide units joined in sequence by peptide linkages.

What is the CAS number of Alpha-msh?

The CAS registry number of Alpha-msh is 581-05-5.

What is the molecular formula and weight of Alpha-msh?

The molecular formula of Alpha-msh is C77H109N21O19S and its molar mass is 1,664.91 g/mol.

What is Alpha-msh used for?

Known uses and roles of Alpha-msh include anti-inflammatory agent and hormones.

Is Alpha-msh hazardous?

No GHS hazard classification for Alpha-msh is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Alpha-msh?

Alpha-msh is usually classified under HS code 293329 (Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Alpha-msh?

CompoundList lists 4 suppliers of Alpha-msh in China and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Alpha-msh?

Suppliers quote Alpha-msh on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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