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Central nervous system drugs

Apomorphine

Also known as L-Apomorphine, Apomorfin, Apomorphin

CAS 58-00-4Formula C17H17NO2Molar mass 267.33 g/molEC 200-360-0
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Apomorphine chemical structure, C17H17NO2, CAS 58-00-4
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Hexagonal plates from chloroform+petroleum ether, rods from ether
Melting point
195 °C
Solubility
MINUTE, WHITE OR GRAYISH WHITE, GLISTENING CRYSTALS OR WHITE POWDER, ODORLESS, SOLN ARE…
HS code
293399
Category
Central nervous system drugs
Illustrative photo, closed jumbo bulk bags in a warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Apomorphine?

Plain description, key identifiers and synonyms

Apomorphine is an aporphine alkaloid. It has a role as an emetic, a serotonergic drug, an antiparkinson drug, an alpha-adrenergic drug, a dopamine agonist and an antidyskinesia agent. It derives from a hydride of an aporphine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol
CAS number
58-00-4 CAS number cross-checkedOther or deprecated CAS: 41372-20-7
EC number
200-360-0
Molecular formula
C17H17NO2
UNII
N21FAR7B4S
InChIKey
VMWNQDUVQKEIOC-CYBMUJFWSA-N
InChI
InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1
Canonical SMILES
CN1CCc2cccc3c2C1Cc1ccc(O)c(O)c1-3
Isomeric SMILES
CN1CCC2=C3[C@H]1CC4=C(C3=CC=C2)C(=C(C=C4)O)O

Synonyms

  • L-Apomorphine
  • Apomorfin
  • Apomorphin
  • R-(-)-Apomorphine
  • Ixense
  • (-)-Apomorphine
  • 6abeta-Aporphine-10,11-diol
  • Apomorphinum
  • (-)-10,11-Dihydroxyaporphine
  • (6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol
  • 4H-Dibenzo(de,g)quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, (R)-
  • (R)-5,6,6a,7-tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol
  • (9R)-10-methyl-10-azatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadeca-1(17),2,4,6,13,15-hexaene-3,4-diol
  • (6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo(de,g)quinoline-10,11-diol
  • (R)-5,6,6a,7-tetrahydro-6-methyl-4H-dibenzo(de,g)quinoline-10,11-diol
  • (9R)-10-methyl-10-azatetracyclo(7.7.1.0^(2,7).0^(13,17))heptadeca-1(16),2(7),3,5,13(17),14-hexaene-3,4-diol
  • (9R)-10-methyl-10-azatetracyclo(7.7.1.0^(2,7).0^(13,17))heptadeca-1(17),2,4,6,13,15-hexaene-3,4-diol
  • (9R)-10-methyl-10-azatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadeca-1(16),2(7),3,5,13(17),14-hexaene-3,4-diol
  • Apomorphin Teclapharm
  • (9R)-10-methyl-10-azatetracyclo(7.7.1.02,7.013,17)heptadeca-1(16),2(7),3,5,13(17),14-hexaene-3,4-diol
  • (R)-(-)-Apomorphine
  • Apormorphine
  • (6aR)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo(de,g)chinolin-10,11-diol
  • Apomorphine (BAN)
  • Uprima (TN)
Show all 33 synonyms
  • (R)?-?(-?)?-?Apomorphine
  • Apomorphine free base
  • 6a-beta-Aporphine-10,11-diol
  • 58-00-4 (free base)
  • Apomorphine (R,-)
  • Tocris-2073
  • Kynmobi (sublingual film)
  • Biomol-NT_000019

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Hexagonal plates from chloroform+petroleum ether, rods from etherexp.
Melting point
195 °Cexp.
Solubility
MINUTE, WHITE OR GRAYISH WHITE, GLISTENING CRYSTALS OR WHITE POWDER, ODORLESS, SOLN ARE NEUTRAL TO LITMUS, LEVOROTATORY IN DIL ACID, 1 G SOL IN 50 ML WATER, IN ABOUT 50 ML ALCOHOL, & IN ABOUT 20 ML WATER @ 80 °C, PPT BY TANNIC ACID & OTHER…exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
267.33 g/molcalc.
Exact mass
267.1259 Dacalc.
LogP (octanol/water)
2.85calc.
Topological polar surface area
43.7 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
0calc.
Heavy atoms
20calc.
Rings
4calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.29calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)CC1NCCc3cccc-2c31

c1ccc2c(c1)CC1NCCc3cccc-2c31

4 rings, 17 atoms.

289 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Apomorphine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 23 suppliers
23 of 23 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

23 suppliers in 10 countries

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Apomorphine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Has been used for (powerful emetic) effect in acute poisoning.

Therapeutic category: Antiparkinsonian, emetic. In treatment of male erectile dysfunction.

Therapeutic category (veterinary): Emetic.

Veterinary medication:.

Use classes: Pharmaceuticals.

Industries and functions

Pharmacological actions

  • Dopamine Agonists
  • Emetics

Roles

  • adrenergic agent
  • alpha-adrenergic drug
  • antidyskinesia agent
  • antiparkinson drug
  • antipsychotic agent
  • cardiovascular drug
  • central nervous system depressant
  • central nervous system drug
  • dopamine agonist
  • dopaminergic agent
  • emetic
  • neuroprotective agent
  • neurotransmitter agent
  • pharmaceutical
  • protective agent
  • psychotropic drug
  • serotonergic drug
  • tranquilizing drug
  • vasodilator agent

Pharmacology

Apomorphine is a Dopaminergic Agonist. The mechanism of action of apomorphine is as a Dopamine Agonist.

How it is made

By heating morphine in a closed tube with a great excess of hcl for 2 or 3 hr @...140-150 °c. The elements of one mole of water are abstracted from morphine, resulting in a change in molecular structure. Upon cooling, crude apomorphine hydrochloride crystallizes out, being less sol in hcl than in water. (Hcl)

Synthetic opiate obtained by treating morphine with concentrated HCl.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Apomorphine ((R)-5,6,6a,7-tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol)) and its salts, Ref no: 42, Annex ref: II/42
  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Apomorphine is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Apomorphine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Apomorphine, based on the data on this page

What is Apomorphine?

Apomorphine is an aporphine alkaloid. It has a role as an emetic, a serotonergic drug, an antiparkinson drug, an alpha-adrenergic drug, a dopamine agonist and an antidyskinesia agent. It derives from a hydride of an aporphine.

What is the CAS number of Apomorphine?

The CAS registry number of Apomorphine is 58-00-4. Other or deprecated CAS numbers: 41372-20-7.

What is the molecular formula and weight of Apomorphine?

The molecular formula of Apomorphine is C17H17NO2 and its molar mass is 267.33 g/mol.

What is Apomorphine used for?

Has been used for (powerful emetic) effect in acute poisoning. Therapeutic category: Antiparkinsonian, emetic. In treatment of male erectile dysfunction. Therapeutic category (veterinary): Emetic. Veterinary medication:. Use classes: Pharmaceuticals.

Is Apomorphine hazardous?

No GHS hazard classification for Apomorphine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Apomorphine?

Apomorphine is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Apomorphine?

CompoundList lists 23 suppliers of Apomorphine in United States, China, Germany, Spain and 6 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Apomorphine?

Suppliers quote Apomorphine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Apomorphine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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