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Screening compounds

Bemcentinib

Also known as BGB 324, WHO 10631, R-428 compound

CAS 1037624-75-1Formula C30H34N8Molar mass 506.66 g/molEC 894-430-3
GHS signal word: Warning. Pictograms: Harmful or irritant 10 suppliers listed
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Bemcentinib chemical structure, C30H34N8, CAS 1037624-75-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1037624-75-1
Formula
C30H34N8
Molar mass
506.66 g/mol
EC number
894-430-3
HS code
293399
Category
Screening compounds

What is Bemcentinib?

Plain description, key identifiers and synonyms

Bemcentinib is an orally available and selective inhibitor of the AXL receptor tyrosine kinase (UFO), with potential antineoplastic activity. Upon administration, bemcentinib targets and binds to the intracellular catalytic kinase domain of AXL and prevents its activity. This blocks AXL-mediated signal transduction pathways and inhibits the epithelial-mesenchymal transition (EMT), which, in turn, inhibits tumor cell proliferation and migration. In addition, bemcentinib enhances chemo-sensitivity. AXL, a member of the TAM (TYRO3, AXL and MER) family of receptor tyrosine kinases overexpressed by many tumor cell types, plays a key role in tumor cell proliferation, survival, invasion and metastasis, its expression is associated with drug resistance and poor prognosis.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-(3,4-diazatricyclo[9.4.0.02,7]pentadeca-1(15),2,4,6,11,13-hexaen-5-yl)-3-N-[(7S)-7-pyrrolidin-1-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]-1,2,4-triazole-3,5-diamine
CAS number
1037624-75-1 CAS number cross-checked
EC number
894-430-3
Molecular formula
C30H34N8
UNII
0ICW2LX8AS
MDL number
MFCD21608463
InChIKey
KXMZDGSRSGHMMK-VWLOTQADSA-N
InChI
InChI=1S/C30H34N8/c31-29-33-30(32-24-13-10-20-11-14-25(15-12-22(20)18-24)37-16-3-4-17-37)36-38(29)27-19-23-8-5-7-21-6-1-2-9-26(21)28(23)35-34-27/h1-2,6,9-10,13,18-19,25H,3-5,7-8,11-12,14-17H2,(H3,31,32,33,36)/t25-/m0/s1
Canonical SMILES
Nc1nc(Nc2ccc3c(c2)CCC(N2CCCC2)CC3)nn1-c1cc2c(nn1)-c1ccccc1CCC2
Isomeric SMILES
C1CCN(C1)[C@H]2CCC3=C(CC2)C=C(C=C3)NC4=NN(C(=N4)N)C5=NN=C6C(=C5)CCCC7=CC=CC=C76

Synonyms

  • BGB 324
  • WHO 10631
  • R-428 compound
  • bemcentinibum
  • AXL Inhibitor BGB324
  • Bemcentinib (GMP)
  • BemcentinibR428BGB324)
  • Bemcentinib (R428)
  • BGB 324, R 428
  • R428 (BGB324)
  • Bemcentinib (USAN/INN)
  • 1H-1,2,4-Triazole-3,5-diamine, 1-(6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-[(7S)-6,7,8,9-tetrahyd

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
506.66 g/molcalc.
Exact mass
506.2906 Dacalc.
LogP (octanol/water)
4.88calc.
Topological polar surface area
97.78 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
4calc.
Heavy atoms
38calc.
Rings
7calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.4calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)CCCc1cc(-n3cnc(Nc4ccc5c(c4)CCC(N4CCCC4)CC5)n3)nnc1-2

c1ccc2c(c1)CCCc1cc(-n3cnc(Nc4ccc5c(c4)CCC(N4CCCC4)CC5)n3)nnc1-2

7 rings, 37 atoms.

3 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Bemcentinib suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 10 suppliers
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Where suppliers are based

10 suppliers in 3 countries

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Bemcentinib price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antimicrobial agent
  • antineoplastic agent
  • antiviral agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Bemcentinib is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Bemcentinib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Bemcentinib, based on the data on this page

What is Bemcentinib?

Bemcentinib is an orally available and selective inhibitor of the AXL receptor tyrosine kinase (UFO), with potential antineoplastic activity. Upon administration, bemcentinib targets and binds to the intracellular catalytic kinase domain of AXL and prevents its activity.

What is the CAS number of Bemcentinib?

The CAS registry number of Bemcentinib is 1037624-75-1.

What is the molecular formula and weight of Bemcentinib?

The molecular formula of Bemcentinib is C30H34N8 and its molar mass is 506.66 g/mol.

What is Bemcentinib used for?

Known uses and roles of Bemcentinib include building blocks in research and laboratory, screening compounds in research and laboratory, antimicrobial agent, antineoplastic agent, antiviral agent and 1 more.

Is Bemcentinib hazardous?

Bemcentinib carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Bemcentinib?

Bemcentinib is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Bemcentinib?

CompoundList lists 10 suppliers of Bemcentinib in China, United States and Spain. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Bemcentinib?

Suppliers quote Bemcentinib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Bemcentinib

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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