Benazepril (CAS 86541-75-5): price, suppliers and safety

What is Benazepril?

Plain description, key identifiers and synonyms

Benazepril is a benzazepine that is benazeprilat in which the carboxy group of the 2-amino-4-phenylbutanoic acid moiety has been converted to the corresponding ethyl ester. It is used (generally as its hydrochloride salt) as a prodrug for the angiotensin-converting enzyme inhibitor benazeprilat in the treatment of hypertension and heart failure. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor and a prodrug. It is an ethyl ester, a lactam, a benzazepine and a dicarboxylic acid monoester. It is functionally related to a benazeprilat. It is a conjugate base of a benazepril(1+).

Benazepril is a chemical compound ACE inhibitor.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name: 2-[(3S)-3-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid
CAS number: 86541-75-5 CAS number cross-checkedOther or deprecated CAS: 109010-10-8, 86499-21-0
Molecular formula: C₂₄H₂₈N₂O₅
UNII: PX47FSF9B3, UDM7Q7QWP8
MDL number: MFCD00864466
InChIKey: XPCFTKFZXHTYIP-PMACEKPBSA-N
InChI: InChI=1S/C24H28N2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28)/t19-,20-/m0/s1
Canonical SMILES: CCOC(=O)C(CCc1ccccc1)NC1CCc2ccccc2N(CC(=O)O)C1=O
Isomeric SMILES: CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@H]2CCC3=CC=CC=C3N(C2=O)CC(=O)O

Synonyms

Benazeprilum
Benazepril Sandoz
Briem
Forteekor
Cibacen ws
2-[(3S)-3-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid
1H-1-Benzazepine-1-acetic acid, 3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2,3,4,5-tetrahydro-2-oxo-, (S-(R*,R*))-
Benazeprilum (Latin)
2-[(3S)-3-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid
benazapril
benzazepril
2-((3S)-3-(((2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetic acid
2-((3S)-3-(((2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino)-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl)acetic acid
Benazepril (INN)
Benazepril Free base
Benazepril, (+/-)-
[(3S)-3-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid
[(3S)-3-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid
1H-1-Benzazepine-1-acetic acid, 3-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-, (3S)-
2-[(3S)-3-[[(1S)-1-ethoxycarbonyl-3-phenyl-propyl]amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid
Benazepril (hydrochloride)
2-((S)-3-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetic acid
Forteekor [veterinary] (TN)
Benazepril (Standard)
[(3S)-3-({(1S)-1-[(ethyloxy)carbonyl]-3-phenylpropyl}amino)-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid

Show all 27 synonyms

(3S)-3-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic Acid
1H-1-Benzazepine-1-acetic acid, 3-[[(1R)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-, (3R)-rel-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Melting point	148 to 149 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight	424.50 g/molcalc.
Exact mass	424.1998 Dacalc.
LogP (octanol/water)	2.57calc.
Topological polar surface area	95.94 Å²calc.
Hydrogen bond donors	2calc.
Hydrogen bond acceptors	5calc.
Rotatable bonds	9calc.
Heavy atoms	31calc.
Rings	3calc.
Aromatic rings	2calc.
Fraction sp3 carbons	0.38calc.
Formal charge	0calc.
Stereocentres	2calc.
Lipinski rule of five	Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

O=C1Nc2ccccc2CCC1NCCCc1ccccc1

3 rings, 22 atoms.

25 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Benazepril suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 36 suppliers

Verified only30 of 30 offers

Vasant Chemicals Private Limited
India, Hyderabad ManufacturerUnclaimed profile
BenazeprilGrade, purity and minimum order on request
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AptoChem
Unclaimed profile
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Suzhou Pharmaceutical Technology co., ltd
China, Suzhou ManufacturerUnclaimed profile
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Euroasia Trans Continental
IndiaUnclaimed profile
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Alfa-Omega Pharma Pvt Ltd
India ManufacturerUnclaimed profile
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Chemicea
India ManufacturerUnclaimed profile
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Analytica Chemie
IndiaUnclaimed profile
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Jayco Chemical Industries
India, ThaneUnclaimed profile
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Chemcopia
India ManufacturerUnclaimed profile
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Hangzhou Minko Chemical Co., Ltd.
China, Hangzhou ManufacturerUnclaimed profile
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

36 suppliers in 7 countries

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Benazepril price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

Use classes: Pharmaceuticals.

Industries and functions

Antihypertensives in pharmaceuticals

Pharmacological actions

Angiotensin-Converting Enzyme Inhibitors
Antihypertensive Agents

Roles

antihypertensive agent
cardiovascular drug
enzyme inhibitor
pharmaceutical
pro-agent
prodrug

Pharmacology

Benazepril is an Angiotensin Converting Enzyme Inhibitor. The mechanism of action of benazepril is as an Angiotensin-converting Enzyme Inhibitor. The physiologic effect of benazepril is by means of Decreased Blood Pressure.

How it is made

Prepn: J. W. H. Watthey, European Patent Office patent 72352, idem, United States of America patent 4410520 (both 1983 to Ciba-Geigy)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Benazepril is traded under.

HS 2933.79Indicative HS code

Lactams, other lactams

World exports in 2024

$16.2B

−64.4% vs 2023, imports $15.4B

2019 to 2024

Top exporters

Ireland37.0%
France * partner reported15.6%
Spain11.3%

Top importers

Germany27.8%
Ireland18.9%
Panama * partner reported12.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Benazepril is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Parent and salt forms, stereoisomers, similar structures and isomers

Salt and hydrate forms

Records that share this compound as their parent

Benazepril hydrochloride chemical structure, C24H29ClN2O5, CAS 86541-74-4

Benazepril hydrochloride86541-74-4C₂₄H₂₉ClN₂O₅113 suppliers

Stereoisomers and isotopic forms

Same connectivity, different stereochemistry or isotopes (same InChIKey skeleton)

3-[[1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid chemical structure, C24H28N2O5, CAS 98626-50-7

3-[[1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid98626-50-7C₂₄H₂₈N₂O₅1 supplier

1H-1-Benzazepine-1-acetic acid, 3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2,3,4,5-tetrahydro-2-oxo- chemical structure, C24H28N2O5, CAS 131064-75-0

1H-1-Benzazepine-1-acetic acid, 3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2,3,4,5-tetrahydro-2-oxo-131064-75-0C₂₄H₂₈N₂O₅1 supplier

[(3RS)-3-[[(1SR)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid chemical structure, C24H28N2O5, CAS 86541-76-6

[(3RS)-3-[[(1SR)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid86541-76-6C₂₄H₂₈N₂O₅1 supplier

((3RS)-3-(((1SR)-1-(Ethoxycarbonyl)-3-phenylpropyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetic-acid chemical structure, C24H28N2O5, CAS 131064-74-9

((3RS)-3-(((1SR)-1-(Ethoxycarbonyl)-3-phenylpropyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetic-acid131064-74-9C₂₄H₂₈N₂O₅

Benazepril-d5 chemical structure, C24H28N2O5, CAS 1279200-03-1

Benazepril-d51279200-03-1C₂₄H₂₈N₂O₅

Similar structures

Nearest neighbours by Morgan fingerprint Tanimoto similarity

Benazepril hydrochloride, (R,R)- chemical structure, C24H29ClN2O5, CAS 215447-89-5

Benazepril ethyl ester chemical structure, C26H32N2O5, CAS 103129-58-4

Benazepril-d5 hydrochloride chemical structure, C24H29ClN2O5, CAS 1279026-26-4

Benazeprilat chemical structure, C22H24N2O5, CAS 86541-78-8

Benazeprilat-d5 chemical structure, C22H24N2O5, CAS 1279033-05-4

Daglutril chemical structure, C31H38N2O6, CAS 182821-27-8

Same formula isomers

Different compounds that share this molecular formula

All isomers

3-Hydroxy-4-(4-isopropoxy-3-methylbenzoyl)-1-(3-methoxypropyl)-5-(4-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C24H28N2O5, CAS 510712-16-0

3-Hydroxy-4-(4-isopropoxy-3-methylbenzoyl)-1-(3-methoxypropyl)-5-(4-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one510712-16-0C₂₄H₂₈N₂O₅

7-Hydroxy-8-[[4-(2-hydroxyethyl)-1-piperazinyl]methyl]-3-(2-methoxyphenyl)-2-methyl-1-benzopyran-4-one chemical structure, C24H28N2O5, CAS 637753-64-1

7-Hydroxy-8-[[4-(2-hydroxyethyl)-1-piperazinyl]methyl]-3-(2-methoxyphenyl)-2-methyl-1-benzopyran-4-one637753-64-1C₂₄H₂₈N₂O₅

4-(Furan-2-carbonyl)-3-hydroxy-5-(4-isopropyl-phenyl)-1-(2-morpholin-4-yl-ethyl)-1,5-dihydro-pyrrol-2-one chemical structure, C24H28N2O5, CAS 380592-09-6

4-(Furan-2-carbonyl)-3-hydroxy-5-(4-isopropyl-phenyl)-1-(2-morpholin-4-yl-ethyl)-1,5-dihydro-pyrrol-2-one380592-09-6C₂₄H₂₈N₂O₅

N-[2-(3,4-Dimethoxyphenyl)ethyl]-6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)hexanamide chemical structure, C24H28N2O5, CAS 303990-66-1

N-[2-(3,4-Dimethoxyphenyl)ethyl]-6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)hexanamide303990-66-1C₂₄H₂₈N₂O₅

3-(2-Ethoxyphenoxy)-7-hydroxy-2-methyl-8-((4-methylpiperazin-1-yl)methyl)-4H-chromen-4-one chemical structure, C24H28N2O5, CAS 844835-75-2

3-(2-Ethoxyphenoxy)-7-hydroxy-2-methyl-8-((4-methylpiperazin-1-yl)methyl)-4H-chromen-4-one844835-75-2C₂₄H₂₈N₂O₅1 supplier

1-(2-Dimethylamino-ethyl)-4-(2,5-dimethyl-benzoyl)-3-hydroxy-5-(4-hydroxy-3-methoxy-phenyl)-1,5-dihydro-pyrrol-2-one chemical structure, C24H28N2O5, CAS 609326-06-9

1-(2-Dimethylamino-ethyl)-4-(2,5-dimethyl-benzoyl)-3-hydroxy-5-(4-hydroxy-3-methoxy-phenyl)-1,5-dihydro-pyrrol-2-one609326-06-9C₂₄H₂₈N₂O₅

5-(3-(Allyloxy)phenyl)-1-(2-(diethylamino)ethyl)-4-(furan-2-carbonyl)-3-hydroxy-1H-pyrrol-2(5H)-one chemical structure, C24H28N2O5, CAS 619273-10-8

5-(3-(Allyloxy)phenyl)-1-(2-(diethylamino)ethyl)-4-(furan-2-carbonyl)-3-hydroxy-1H-pyrrol-2(5H)-one619273-10-8C₂₄H₂₈N₂O₅

N-[2-(3,4-Diethoxyphenyl)ethyl]-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanamide chemical structure, C24H28N2O5, CAS 627055-85-0

N-[2-(3,4-Diethoxyphenyl)ethyl]-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanamide627055-85-0C₂₄H₂₈N₂O₅

Streptophenazine A chemical structure, C24H28N2O5, CAS 1018439-63-8

Streptophenazine A1018439-63-8C₂₄H₂₈N₂O₅

Ethyl 4-(2-(1,3-dioxo-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindol-2(3H)-yl)-4-methylpentanamido)benzoate chemical structure, C24H28N2O5, CAS 1094605-32-9

Ethyl 4-(2-(1,3-dioxo-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindol-2(3H)-yl)-4-methylpentanamido)benzoate1094605-32-9C₂₄H₂₈N₂O₅

3-Hydroxy-4-(4-isopropoxy-3-methylbenzoyl)-1-(3-methoxypropyl)-5-(3-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C24H28N2O5, CAS 510712-17-1

3-Hydroxy-4-(4-isopropoxy-3-methylbenzoyl)-1-(3-methoxypropyl)-5-(3-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one510712-17-1C₂₄H₂₈N₂O₅

3-(3,4-Dimethoxyphenyl)-7-hydroxy-4-methyl-8-[(4-methylpiperazin-1-yl)methyl]-2H-chromen-2-one chemical structure, C24H28N2O5, CAS 869340-73-8

3-(3,4-Dimethoxyphenyl)-7-hydroxy-4-methyl-8-[(4-methylpiperazin-1-yl)methyl]-2H-chromen-2-one869340-73-8C₂₄H₂₈N₂O₅

Frequently asked questions

Quick answers about Benazepril, based on the data on this page

What is Benazepril?

Benazepril is a benzazepine that is benazeprilat in which the carboxy group of the 2-amino-4-phenylbutanoic acid moiety has been converted to the corresponding ethyl ester.

What is the CAS number of Benazepril?

The CAS registry number of Benazepril is 86541-75-5. Other or deprecated CAS numbers: 109010-10-8, 86499-21-0.

What is the molecular formula and weight of Benazepril?

The molecular formula of Benazepril is C24H28N2O5 and its molar mass is 424.50 g/mol.

What is Benazepril used for?

Veterinary medication:. Use classes: Pharmaceuticals.

Is Benazepril hazardous?

No GHS hazard classification for Benazepril is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Benazepril?

Benazepril is usually classified under HS code 293379 (Lactams, other lactams). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Benazepril?

CompoundList lists 36 suppliers of Benazepril in India, United States, China, Hong Kong and 3 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Benazepril in India?

11 suppliers in India list Benazepril on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Benazepril?

Suppliers quote Benazepril on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Benazepril

Benazepril

Key facts

What is Benazepril?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Murcko scaffold

Safety and hazards

Benazepril suppliers

Where suppliers are based

Send one request to many suppliers

Benazepril price

Uses and applications

Industries and functions

Pharmacological actions

Roles

Pharmacology

How it is made

Regulatory status

Health and food

HS code and trade data

Global trade

Frequently asked questions

What is Benazepril?

What is the CAS number of Benazepril?

What is the molecular formula and weight of Benazepril?

What is Benazepril used for?

Is Benazepril hazardous?

What is the HS code of Benazepril?

Where can I buy Benazepril?

Where can I buy Benazepril in India?

What is the price of Benazepril?

Guides for buyers

Get quotes for Benazepril

Key facts

What is Benazepril?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Murcko scaffold

Safety and hazards

Benazepril suppliers

Where suppliers are based

Send one request to many suppliers

Benazepril price

Uses and applications

Industries and functions

Pharmacological actions

Roles

Pharmacology

How it is made

Regulatory status

Health and food

HS code and trade data

Global trade

Related chemicals

Salt and hydrate forms

Stereoisomers and isotopic forms

Similar structures

Same formula isomers

Frequently asked questions

What is Benazepril?

What is the CAS number of Benazepril?

What is the molecular formula and weight of Benazepril?

What is Benazepril used for?

Is Benazepril hazardous?

What is the HS code of Benazepril?

Where can I buy Benazepril?

Where can I buy Benazepril in India?

What is the price of Benazepril?

Guides for buyers

Get quotes for Benazepril