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Oncology and immunology drugs

Bendamustine hydrochloride

Also known as Bendamustine HCl, Treanda, Ribomustin

CAS 3543-75-7Formula C16H22Cl3N3O2Molar mass 394.73 g/molEC 631-540-0
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Serious health hazard 138 suppliers listed Drug substance
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Bendamustine hydrochloride chemical structure, C16H22Cl3N3O2, CAS 3543-75-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
3543-75-7
Formula
C16H22Cl3N3O2
Molar mass
394.73 g/mol
EC number
631-540-0
HS code
293399
Category
Oncology and immunology drugs

What is Bendamustine hydrochloride?

Plain description, key identifiers and synonyms

Bendamustine Hydrochloride is the hydrochloride salt of bendamustine, a bifunctional mechlorethamine derivative with alkylator and antimetabolite activities. Bendamustine possesses three active moieties: an alkylating group, a benzimidazole ring, which may act as a purine analogue, and a butyric acid side chain. Although its exact mechanism of action is unknown this agent appears to act primarily as an alkylator. Bendamustine metabolites alkylate and crosslink macromolecules, resulting in DNA, RNA and protein synthesis inhibition, and, subsequently, apoptosis. Bendamustine may differ from other alkylators in that it may be more potent in activating p53-dependent stress pathways and inducing apoptosis, it may induce mitotic catastrophe, and it may activate a base excision DNA repair pathway rather than an alkyltransferase DNA repair mechanism. Accordingly, this agent may be more efficacious and less susceptible to drug resistance than other alkylators.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid, hydrochloride
CAS number
3543-75-7 CAS number cross-checkedOther or deprecated CAS: 97832-05-8
EC number
631-540-0
Molecular formula
C16H22Cl3N3O2
UNII
981Y8SX18M
MDL number
MFCD01658758, MFCD16879055
InChIKey
ZHSKUOZOLHMKEA-UHFFFAOYSA-N
InChI
InChI=1S/C16H21Cl2N3O2.ClH/c1-20-14-6-5-12(21(9-7-17)10-8-18)11-13(14)19-15(20)3-2-4-16(22)23;/h5-6,11H,2-4,7-10H2,1H3,(H,22,23);1H
SMILES (canonical and isomeric)
CN1C2=C(C=C(C=C2)N(CCCl)CCCl)N=C1CCCC(=O)O.Cl

Synonyms

  • Bendamustine HCl
  • Treanda
  • Ribomustin
  • Bendamustin hydrochloride
  • Bendeka
  • Ribomustine
  • SyB L-0501
  • Vivimusta
  • Levact
  • SYBL-0501
  • 1H-Benzimidazole-2-butanoic acid, 5-(bis(2-chloroethyl)amino)-1-methyl-, monohydrochloride
  • 2-Benzimidazolinebutryric acid, 1-methyl-5-bis(2-chloroethyl)amino-, hydrochloride
  • bendamustin
  • Belrapzo
  • Cytostasan Hydrochloride
  • Hydrochloride, Bendamustine
  • Cytostasan
  • 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid hydrochloride
  • 4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid hydrochloride
  • IMET 3393
  • Bendamustine (hydrochloride)
  • SDX 105
  • 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo-[d]imidazol-2-yl)butanoic acid hydrochloride
  • 4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid, hydrochloride
  • Treanda (TN)
Show all 37 synonyms
  • 2-Benzimidazolebutyric acid, monohydrochloride
  • 1H-Benzimidazole-2-butanoicacid, 5-[bis(2-chloroethyl)amino]-1-methyl-, hydrochloride (1:?)
  • Treakisym
  • Bendit
  • Bendamustine hydrochloride (usp monograph)
  • Cytostosan
  • Innomustine
  • Symbenda
  • 3543-75-7 (HCl)
  • Benda
  • C16H22Cl3N3O2
  • Ribomustin,

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
394.73 g/molcalc.
Exact mass
393.0778 Dacalc.
LogP (octanol/water)
3.69calc.
Topological polar surface area
58.36 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
9calc.
Heavy atoms
24calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.5calc.
Formal charge
0calc.
Stereocentres
0calc.
Components
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2[nH]cnc2c1

c1ccc2[nH]cnc2c1

2 rings, 9 atoms, the Benzimidazole ring system.

8,995 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H301Toxic if swallowed.
  • H340May cause genetic defects.
  • H350May cause cancer.
  • H351Suspected of causing cancer.
  • H360May damage fertility or the unborn child.
Precautionary statements (10)
  • P203Obtain, read and follow all safety instructions before use.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Bendamustine hydrochloride suppliers

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All 138 suppliers
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Where suppliers are based

138 suppliers in 20 countries

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Bendamustine hydrochloride price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Pharmacological actions

  • Antineoplastic Agents, Alkylating

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Bendamustine hydrochloride is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Bendamustine hydrochloride is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Bendamustine hydrochloride, based on the data on this page

What is Bendamustine hydrochloride?

Bendamustine Hydrochloride is the hydrochloride salt of bendamustine, a bifunctional mechlorethamine derivative with alkylator and antimetabolite activities. Bendamustine possesses three active moieties: an alkylating group, a benzimidazole ring, which may act as a purine analogue, and a butyric acid side chain.

What is the CAS number of Bendamustine hydrochloride?

The CAS registry number of Bendamustine hydrochloride is 3543-75-7. Other or deprecated CAS numbers: 97832-05-8.

What is the molecular formula and weight of Bendamustine hydrochloride?

The molecular formula of Bendamustine hydrochloride is C16H22Cl3N3O2 and its molar mass is 394.73 g/mol.

What is Bendamustine hydrochloride used for?

Known uses and roles of Bendamustine hydrochloride include anticancer drugs in pharmaceuticals, antineoplastic agent, pharmaceutical and antineoplastic agents, alkylating.

Is Bendamustine hydrochloride hazardous?

Bendamustine hydrochloride carries the GHS signal word "Danger". Main hazards: toxic if swallowed, may cause genetic defects, may cause cancer. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Bendamustine hydrochloride?

Bendamustine hydrochloride is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Bendamustine hydrochloride?

CompoundList lists 138 suppliers of Bendamustine hydrochloride in China, United States, India, Germany and 16 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Bendamustine hydrochloride in India?

18 suppliers in India list Bendamustine hydrochloride on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Bendamustine hydrochloride?

Suppliers quote Bendamustine hydrochloride on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Bendamustine hydrochloride

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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