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Bendamustine

Also known as Bendamustina, 4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid, Bendamustinum

CAS 16506-27-7Formula C16H21Cl2N3O2Molar mass 358.27 g/molEC 680-659-4
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Serious health hazard 90 suppliers listed Drug substance
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Bendamustine chemical structure, C16H21Cl2N3O2, CAS 16506-27-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
16506-27-7
Formula
C16H21Cl2N3O2
Molar mass
358.27 g/mol
EC number
680-659-4
HS code
293399
Category
Pharmaceuticals and APIs

What is Bendamustine?

Plain description, key identifiers and synonyms

Bendamustine is a member of benzimidazoles.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid
CAS number
16506-27-7 CAS number cross-checked
EC number
680-659-4
Molecular formula
C16H21Cl2N3O2
UNII
9266D9P3PQ
MDL number
MFCD00866481
InChIKey
YTKUWDBFDASYHO-UHFFFAOYSA-N
InChI
InChI=1S/C16H21Cl2N3O2/c1-20-14-6-5-12(21(9-7-17)10-8-18)11-13(14)19-15(20)3-2-4-16(22)23/h5-6,11H,2-4,7-10H2,1H3,(H,22,23)
SMILES (canonical and isomeric)
CN1C2=C(C=C(C=C2)N(CCCl)CCCl)N=C1CCCC(=O)O

Synonyms

  • Bendamustina
  • 4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid
  • Bendamustinum
  • 1H-Benzimidazole-2-butanoic acid, 5-(bis(2-chloroethyl)amino)-1-methyl-
  • 5-(Bis(2-chloroethyl)amino)-1-methyl-2-benzimidazolebutyric acid
  • 4-{5-[bis(2-chloroethyl)amino]-1-methyl-1H-1,3-benzodiazol-2-yl}butanoic acid
  • omega-(1-Methyl-5-bis(beta-chloroethyl)aminobenzimidazole-(2)-butyric acid
  • 1H-benzimidazole-2-butanoic acid, 5-[bis(2-chloroethyl)amino]-1-methyl-
  • 4-(5-(bis(2-chloroethyl)amino)-1-methylbenzimidazol-2-yl)butanoic acid
  • 4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-1,3-benzodiazol-2-yl)butanoic acid
  • 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid
  • 16506-27-7 (free base)
  • Treanda (TN)
  • SDX 105
  • NIOSH/DD6304600
  • Bendamustine (INN)
  • Bendamustinum (Latin)
  • Bendamustine free base
  • 5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzimidazole-2-butanoic acid
  • C16H21Cl2N3O2
  • SDX-105 free base
  • Sdccgsbi-0633739.p001
  • 4-(5-(Bis(2-chloroethyl)amino)-1-me
  • US9096627, CY190602
  • 4-[5-[Bis(2-chloroethyl)amino]-1-methyl-2-benzimidazolyl]butanoic Acid
Show all 29 synonyms
  • 4-[5-[bis(2-chloroethyl)amino]-1-methyl-benzimidazol-2-yl]butanoic acid
  • 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzimidazole-2-yl)butanoic acid
  • 4-{5-[Bis(2-chloroethyl)amino]-1-methyl-1H-1,3-benzimidazol-2-yl}butanoic acid
  • 4-{5-[bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazol-2-yl}butanoic acid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
358.27 g/molcalc.
Exact mass
357.1011 Dacalc.
LogP (octanol/water)
3.26calc.
Topological polar surface area
58.36 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
9calc.
Heavy atoms
23calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.5calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2[nH]cnc2c1

c1ccc2[nH]cnc2c1

2 rings, 9 atoms, the Benzimidazole ring system.

8,995 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H301Toxic if swallowed.
  • H341Suspected of causing genetic defects.
  • H351Suspected of causing cancer.
  • H360May damage fertility or the unborn child.
Precautionary statements (10)
  • P203Obtain, read and follow all safety instructions before use.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Bendamustine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 90 suppliers
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Where suppliers are based

90 suppliers in 18 countries

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Bendamustine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Alkylating drug indicated for the treatment of patients with chronic lymphocytic leukemia (Bandamustine hydrochloride).

Bifunctional alkylating agent.[The Merck Index, Fourteenth Edition (2006).

Therapeutic category: Antineoplastic.

Roles

  • anti-anaemic agent
  • antineoplastic agent
  • pharmaceutical

Pharmacology

Bendamustine is an Alkylating Drug. The mechanism of action of bendamustine is as an Alkylating Activity.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Bendamustine is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Bendamustine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Bendamustine, based on the data on this page

What is Bendamustine?

Bendamustine is a member of benzimidazoles.

What is the CAS number of Bendamustine?

The CAS registry number of Bendamustine is 16506-27-7.

What is the molecular formula and weight of Bendamustine?

The molecular formula of Bendamustine is C16H21Cl2N3O2 and its molar mass is 358.27 g/mol.

What is Bendamustine used for?

Alkylating drug indicated for the treatment of patients with chronic lymphocytic leukemia (Bandamustine hydrochloride). Bifunctional alkylating agent.[The Merck Index, Fourteenth Edition (2006). Therapeutic category: Antineoplastic.

Is Bendamustine hazardous?

Bendamustine carries the GHS signal word "Danger". Main hazards: toxic if swallowed, suspected of causing genetic defects, suspected of causing cancer. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Bendamustine?

Bendamustine is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Bendamustine?

CompoundList lists 90 suppliers of Bendamustine in United States, China, India, Germany and 14 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Bendamustine in India?

12 suppliers in India list Bendamustine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Bendamustine?

Suppliers quote Bendamustine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Bendamustine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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