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Screening compounds

Bevurogant

Also known as 7(8H)-Pteridinone, 8-((1S)-1-cyclopropylethyl)-2-(4-cyclopropyl-6-methyl-5-pyrimidinyl)-6-(((5-(methylsulfonyl)-2-pyridinyl)methyl)amino)-, (S)-2-(4-cyclopropyl-6-methylpyrimidin-5-yl)-8-(1-cyclopropylethyl)-6-(((5-(methylsulfonyl)pyridin-2-yl)methyl)amino)pteridin-7(8H)-one, 8-[(1S)-1-cyclopropylethyl]-2-(4-cyclopropyl-6-methylpyrimidin-5-yl)-6-[(5-methylsulfonylpyridin-2-yl)methylamino]pteridin-7-one

CAS 1817773-66-2Formula C26H28N8O3SMolar mass 532.63 g/molEC 815-328-7
GHS signal word: Warning. Pictograms: Serious health hazard
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Bevurogant chemical structure, C26H28N8O3S, CAS 1817773-66-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1817773-66-2
Formula
C26H28N8O3S
Molar mass
532.63 g/mol
EC number
815-328-7
HS code
293359
Category
Screening compounds

What is Bevurogant?

Plain description, key identifiers and synonyms

Bevurogant is a chemical substance with the molecular formula C26H28N8O3S and a molar mass of 532.63 g/mol. Its CAS registry number is 1817773-66-2. The IUPAC name is 8-[(1S)-1-cyclopropylethyl]-2-(4-cyclopropyl-6-methylpyrimidin-5-yl)-6-[(5-methylsulfonyl-2-pyridinyl)methylamino]pteridin-7-one.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
8-[(1S)-1-cyclopropylethyl]-2-(4-cyclopropyl-6-methylpyrimidin-5-yl)-6-[(5-methylsulfonyl-2-pyridinyl)methylamino]pteridin-7-one
CAS number
1817773-66-2
EC number
815-328-7
Molecular formula
C26H28N8O3S
UNII
1874HVK11I
InChIKey
HVVHIBHBDCYLDI-HNNXBMFYSA-N
InChI
InChI=1S/C26H28N8O3S/c1-14-21(22(17-6-7-17)31-13-30-14)23-29-12-20-25(33-23)34(15(2)16-4-5-16)26(35)24(32-20)28-10-18-8-9-19(11-27-18)38(3,36)37/h8-9,11-13,15-17H,4-7,10H2,1-3H3,(H,28,32)/t15-/m0/s1
Canonical SMILES
Cc1ncnc(C2CC2)c1-c1ncc2nc(NCc3ccc(S(C)(=O)=O)cn3)c(=O)n(C(C)C3CC3)c2n1
Isomeric SMILES
CC1=C(C(=NC=N1)C2CC2)C3=NC=C4C(=N3)N(C(=O)C(=N4)NCC5=NC=C(C=C5)S(=O)(=O)C)[C@@H](C)C6CC6

Synonyms

  • 7(8H)-Pteridinone, 8-((1S)-1-cyclopropylethyl)-2-(4-cyclopropyl-6-methyl-5-pyrimidinyl)-6-(((5-(methylsulfonyl)-2-pyridinyl)methyl)amino)-
  • (S)-2-(4-cyclopropyl-6-methylpyrimidin-5-yl)-8-(1-cyclopropylethyl)-6-(((5-(methylsulfonyl)pyridin-2-yl)methyl)amino)pteridin-7(8H)-one
  • 8-[(1S)-1-cyclopropylethyl]-2-(4-cyclopropyl-6-methylpyrimidin-5-yl)-6-[(5-methylsulfonylpyridin-2-yl)methylamino]pteridin-7-one
  • Bevurogant, 10 mM in DMSO
  • 2-(4-cyclopropyl-6-methylpyrimidin-5-yl)-8-[(1S)-1-cyclopropylethyl]-6-{[(5-methanesulfonylpyridin-2-yl)methyl]amino}-7,8-dihydropteridin-7-one
  • BI 730357
  • US9598415, 136
  • ROR,RAR-related orphan receptor,inhibit,Bevurogant,Inhibitor
  • 8-((S)-1-Cyclopropyl-ethyl)-2-(4-cyclopropyl-6-methyl-pyrimidin-5-yl)-6-[(5-methanesulfonyl-pyridin-2-ylmethyl)-amino]-8H-pteridin-7-one
  • 8-[(1S)-1-cyclopropylethyl]-2-(4-cyclopropyl-6-methylpyrimidin-5-yl)-6-[(5-methylsulfonyl-2-pyridinyl)methylamino]pteridin-7-one

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
532.63 g/molcalc.
Exact mass
532.2005 Dacalc.
LogP (octanol/water)
3.21calc.
Topological polar surface area
145.5 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
10calc.
Rotatable bonds
8calc.
Heavy atoms
38calc.
Rings
6calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.42calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1c(NCc2ccccn2)nc2cnc(-c3cncnc3C3CC3)nc2n1CC1CC1

O=c1c(NCc2ccccn2)nc2cnc(-c3cncnc3C3CC3)nc2n1CC1CC1

6 rings, 32 atoms.

No other chemical in our database has this scaffold.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H373May cause damage to organs through prolonged or repeated exposure.
Precautionary statements (3)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P319Get medical help if you feel unwell.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

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Bevurogant price

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Uses and applications

What the substance is used for, by industry and function

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Bevurogant is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Bevurogant is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Bevurogant, based on the data on this page

Is Bevurogant hazardous?

Bevurogant carries the GHS signal word "Warning". Main hazards: may cause damage to organs through prolonged or repeated exposure. This summary is not an SDS, always read the supplier safety data sheet.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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