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Buffers and biological buffers

Bistris

Also known as bis-tris, 2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol

CAS 6976-37-0Formula C8H19NO5Molar mass 209.24 g/molEC 230-237-7
GHS signal word: Danger. Pictograms: Corrosive, Harmful or irritant 59 suppliers listed
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Bistris chemical structure, C8H19NO5, CAS 6976-37-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
6976-37-0
Formula
C8H19NO5
Molar mass
209.24 g/mol
Physical form
Liquid
HS code
292219
Category
Buffers and biological buffers
Illustrative photo, 25 litre white jerry cans of liquid in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Bistris?

Plain description, key identifiers and synonyms

Bis-tris is a buffer substance useful for calibration of glass electrodes and for the preparation of the biochemical and biological buffer solutions, pKa = 6.46 at 25 C. It has a role as a buffer. It is functionally related to a member of tris.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol
CAS number
6976-37-0 CAS number cross-checked
EC numbers
230-237-7, 686-880-2
Molecular formula
C8H19NO5
UNII
Q1XC3631CP
MDL number
MFCD00002853
INCI name
BIS-HYDROXYETHYL TROMETHAMINE
InChIKey
OWMVSZAMULFTJU-UHFFFAOYSA-N
InChI
InChI=1S/C8H19NO5/c10-3-1-9(2-4-11)8(5-12,6-13)7-14/h10-14H,1-7H2
SMILES (canonical and isomeric)
C(CO)N(CCO)C(CO)(CO)CO

Synonyms

  • bis-tris
  • 2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol
  • 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol
  • 2-(Bis(2-hydroxyethyl)amino)-2-(hydroxymethyl)propane-1,3-diol
  • 1,3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-
  • 1,3-Propanediol, 2-(bis(2-hydroxyethyl)amino)-2-(hydroxymethyl)-
  • 2,2-Bis[hydroxymethyl]-2,2',2''-nitrilotriethanol
  • bis(2-hydroxyethyl)imino-tris(hydroxymethyl)methane
  • 2-(bis(2-hydroxyethyl)amino)-2(hydroxymethyl)-1,3-propanediol
  • 2,2-Bis(hydroxyethyl)-(iminotris)-(hydroxymethyl)methane
  • Bis(2-hydroxyethyl)aminotris(hydroxymethyl)methane
  • Bis-tris buffer
  • Bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane
  • 2-[Bis-(2-hydroxy-ethyl)-amino]-2-hydroxymethyl-propane-1,3-diol
  • 2,2-Bis(hydroxymethyl)-2,2,2-nitrilotriethanol
  • 2-(Bis(2-hydroxyethyl)amino))-2-hydroxymethyl-1,3-propanediol
  • Bis-(2-hydroxyethyl)aminotris(hydroxymethyl)methane
  • Bistris, NSC 119932, NSC 24868, NuPage Bis-Tris
  • Bis(2-hydroxyethyl)iminotris(hydroxymethyl)methane BIS-TRIS
  • 1, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-
  • 2-[Bis(2-hydroxyethyl)amino)]-2-hydroxymethyl-1,3-propanediol
  • 2-(bis(2-hydroxyethyl)amino)-2-(hydroxymethyl)-1,3-propanediol
  • 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-1,3-propanediol
  • 2,2-Bis(hydroxymethyl)-2,2',2"-nitrilotriethanol
  • BIS-TRIS, >=98.0% (titration)
Show all 36 synonyms
  • BIS-TRIS, BioUltra, >=99.0% (NT)
  • BIS-TRIS, BioXtra, >=99.0% (NT)
  • BIS-TRIS, BioXtra, >=98.0% (titration)
  • 2,2-Bishydroxymethyl-2,2',2''-nitriloethanol
  • Bis(2-hydroxyethyl)-(iminotris)hydroxymethyl)methane
  • Bis-2-hydroxy-imino-tris-hydroxymethyl-methane
  • 2,2-Bis-(hydroxymethyl)-2,2 ,2 - nitrilotriethanol
  • Bis[2-Hydroxyethyl] imino Tris-(Hydroxymethyl)-methane
  • 2,2-Bis-(hydroxymethyl)-2,2 ,2 -<R>nitrilotriethanol
  • BIS-TRIS, anhydrous, free-flowing, Redi-Dri(TM), >=98.0%
  • 2,2 - Bis(hydroxyethyl)-(iminotris)-(hydroxymethyl)methane

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Physical form
Liquidexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
209.24 g/molcalc.
Exact mass
209.1263 Dacalc.
LogP (octanol/water)
-3.01calc.
Topological polar surface area
104.4 Ųcalc.
Hydrogen bond donors
5calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
8calc.
Heavy atoms
14calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS05: Corrosive
Corrosive
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H318Causes serious eye damage.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (18)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P317Get medical help.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Bistris suppliers

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All 59 suppliers
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Where suppliers are based

59 suppliers in 10 countries

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Bistris price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Industrial uses: Intermediate.

Industries and functions

Cosmetic ingredient, INCI name BIS-HYDROXYETHYL TROMETHAMINE(buffering)

Pharmacological actions

  • Buffers

Roles

  • buffer

Functional uses

  • pH regulating agent

Cosmetic functions

  • Buffering

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Bistris is traded under.

HS 2922.19Indicative HS code

Amino-alcohols, other than those containing more than one kind of oxygen function, their…

World exports in 2024
$2.2B
−4.7% vs 2023, imports $2.27B
2019 to 2024
Top exporters
  1. China21.7%
  2. Germany17.3%
  3. United States15.6%
Top importers
  1. India * partner reported11.0%
  2. United States9.0%
  3. Germany7.2%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Bistris is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Bistris, based on the data on this page

What is Bistris?

Bis-tris is a buffer substance useful for calibration of glass electrodes and for the preparation of the biochemical and biological buffer solutions, pKa = 6.46 at 25 C. It has a role as a buffer. It is functionally related to a member of tris.

What is the CAS number of Bistris?

The CAS registry number of Bistris is 6976-37-0.

What is the molecular formula and weight of Bistris?

The molecular formula of Bistris is C8H19NO5 and its molar mass is 209.24 g/mol.

What is Bistris used for?

Industrial uses: Intermediate.

Is Bistris hazardous?

Bistris carries the GHS signal word "Danger". Main hazards: causes skin irritation, causes serious eye damage, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Bistris?

Bistris is usually classified under HS code 292219 (Amino-alcohols, other than those containing more than one kind of oxygen function, their…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Bistris?

CompoundList lists 59 suppliers of Bistris in China, United States, Germany, Canada and 6 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Bistris?

Suppliers quote Bistris on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Bistris

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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