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Screening compounds

Bleximenib

Also known as Menin-MLL inhibitor 24, (R)-N-Ethyl-5-fluoro-N-isopropyl-2-[[5-[2-[6-[(2-methoxyethyl)(methyl)amino]-2-methylhexan-3-yl]-2,6-diazaspiro[3.4]octan-6-yl]-1,2,4-triazin-6-yl]oxy]benzamide, Bleximenib (USAN/INN)

CAS 2654081-35-1Formula C32H50FN7O3Molar mass 599.80 g/mol
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Bleximenib chemical structure, C32H50FN7O3, CAS 2654081-35-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
2654081-35-1
Formula
C32H50FN7O3
Molar mass
599.80 g/mol
HS code
293369
Category
Screening compounds

What is Bleximenib?

Plain description, key identifiers and synonyms

Bleximenib is an orally bioavailable protein-protein interaction (PPI) inhibitor of the menin-mixed lineage leukemia (MLL, mixed-lineage leukemia 1, MLL1, myeloid/lymphoid leukemia, histone-lysine N-methyltransferase 2A, KMT2A) proteins, with potential antineoplastic activity. Upon oral administration, bleximenib inhibits the interaction between the two proteins menin and MLL and the formation of the menin-MLL complex. This reduces the expression of downstream target genes and results in an inhibition of the proliferation of leukemic cells with either KMT2A alterations such as gene rearrangements (KMT2A-r), duplications, and amplification, or nucleophosmin 1 gene (NPM1) alterations. The menin-MLL complex plays a key role in the survival, growth, transformation and proliferation of certain kinds of leukemia cells.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-ethyl-5-fluoro-2-[[5-[2-[(3R)-6-[2-methoxyethyl(methyl)amino]-2-methylhexan-3-yl]-2,7-diazaspiro[3.4]octan-7-yl]-1,2,4-triazin-6-yl]oxy]-N-propan-2-ylbenzamide
CAS number
2654081-35-1
Molecular formula
C32H50FN7O3
UNII
DCN5WEN78T
MDL number
MFCD35065359
InChIKey
PDUGAXSIWNMIBQ-HHHXNRCGSA-N
InChI
InChI=1S/C32H50FN7O3/c1-8-40(24(4)5)31(41)26-18-25(33)11-12-28(26)43-30-29(34-22-35-36-30)38-15-13-32(19-38)20-39(21-32)27(23(2)3)10-9-14-37(6)16-17-42-7/h11-12,18,22-24,27H,8-10,13-17,19-21H2,1-7H3/t27-/m1/s1
Canonical SMILES
CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CCC2(C1)CN(C(CCCN(C)CCOC)C(C)C)C2)C(C)C
Isomeric SMILES
CCN(C(C)C)C(=O)C1=C(C=CC(=C1)F)OC2=C(N=CN=N2)N3CCC4(C3)CN(C4)[C@H](CCCN(C)CCOC)C(C)C

Synonyms

  • Menin-MLL inhibitor 24
  • (R)-N-Ethyl-5-fluoro-N-isopropyl-2-[[5-[2-[6-[(2-methoxyethyl)(methyl)amino]-2-methylhexan-3-yl]-2,6-diazaspiro[3.4]octan-6-yl]-1,2,4-triazin-6-yl]oxy]benzamide
  • Bleximenib (USAN/INN)
  • JNJ6617 HCl
  • JNJ-6617 HCl
  • Compound A
  • US20240261292, Compound A1
  • US20240261292, Compound A3
  • (R)-N-Ethyl-5-fluoro-N-isopropyl-2-[[5-[2-[6-[(2-methoxyethyl)(methyl)amino]-2-methyl-3-hexyl]-2,6-diazaspiro[3.4]octan-6-yl]-1,2,4-triazin-6-yl]oxy]benzamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
599.80 g/molcalc.
Exact mass
599.3959 Dacalc.
LogP (octanol/water)
4.57calc.
Topological polar surface area
87.16 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
9calc.
Rotatable bonds
15calc.
Heavy atoms
43calc.
Rings
4calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.69calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(Oc2nncnc2N2CCC3(CNC3)C2)cc1

c1ccc(Oc2nncnc2N2CCC3(CNC3)C2)cc1

4 rings, 21 atoms.

9 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Bleximenib suppliers

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Bleximenib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Bleximenib is traded under.

HS 2933.69Indicative HS code

Compounds containing an unfused triazine ring (whether or not hydrogenated) in the…

World exports in 2024
$2.46B
+1.8% vs 2023, imports $2.44B
2019 to 2024
Top exporters
  1. China53.6%
  2. Germany11.5%
  3. India * partner reported8.4%
Top importers
  1. United States13.5%
  2. Brazil9.6%
  3. Germany9.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Bleximenib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Bleximenib, based on the data on this page

What is Bleximenib?

Bleximenib is an orally bioavailable protein-protein interaction (PPI) inhibitor of the menin-mixed lineage leukemia (MLL, mixed-lineage leukemia 1, MLL1, myeloid/lymphoid leukemia, histone-lysine N-methyltransferase 2A, KMT2A) proteins, with potential antineoplastic activity.

What is the CAS number of Bleximenib?

The CAS registry number of Bleximenib is 2654081-35-1.

What is the molecular formula and weight of Bleximenib?

The molecular formula of Bleximenib is C32H50FN7O3 and its molar mass is 599.80 g/mol.

What is Bleximenib used for?

Known uses and roles of Bleximenib include building blocks in research and laboratory and screening compounds in research and laboratory.

Is Bleximenib hazardous?

No GHS hazard classification for Bleximenib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Bleximenib?

Bleximenib is usually classified under HS code 293369 (Compounds containing an unfused triazine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Bleximenib?

Post a free request on CompoundList and suppliers of Bleximenib will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Bleximenib?

Suppliers quote Bleximenib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Bleximenib

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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