CompoundList
Sign in
Central nervous system drugs

Bupropion

Also known as Amfebutamone, 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one, Amfebutamon

CAS 34911-55-2Formula C13H18ClNOMolar mass 239.75 g/mol
GHS signal word: Warning. Pictograms: Harmful or irritant 40 suppliers listed Drug substance
Get quotes Compare 40 suppliers
Bupropion chemical structure, C13H18ClNO, CAS 34911-55-2
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Pale yellow oil
Boiling point
52 °C
Solubility
Very hygroscopic and susceptible to decomposition
HS code
292239
Category
Central nervous system drugs
Illustrative photo, jerry cans of golden oil in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Bupropion?

Plain description, key identifiers and synonyms

Bupropion is an aromatic ketone that is propiophenone carrying a tert-butylamino group at position 2 and a chloro substituent at position 3 on the phenyl ring. It has a role as an antidepressant, a xenobiotic and an environmental contaminant. It is a secondary amino compound, an aromatic ketone and a member of monochlorobenzenes.

Bupropion is a substituted cathinone medication mainly for depression and smoking cessation.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one
CAS number
34911-55-2 CAS number cross-checkedOther or deprecated CAS: 34841-39-9
Molecular formula
C13H18ClNO
UNII
01ZG3TPX31
MDL number
MFCD00865373
InChIKey
SNPPWIUOZRMYNY-UHFFFAOYSA-N
InChI
InChI=1S/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3
SMILES (canonical and isomeric)
CC(C(=O)C1=CC(=CC=C1)Cl)NC(C)(C)C

Synonyms

  • Amfebutamone
  • 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one
  • Amfebutamon
  • amfebutamonum
  • Amfebutamona
  • (+-)-Bupropion
  • Elontril
  • Bupropion slow release
  • bupropione
  • Bupropion extended release
  • alpha-(tert-butylamino)-m-chloropropiophenone
  • (+-)-1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone
  • (+-)-2-(tert-Butylamino)-3'-chlorpropiophenon
  • (+-)-2-(tert-Butylamino)-3'-chloropropiophenone
  • 1-Propanone, 1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)-, (+-)-
  • 1-Propanone, 1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)-
  • 1-Propanone, 1-(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]-
  • bupropionum
  • Zyban (Bupropion)
  • Wellbutrin
  • Zyban
  • Wellbatrin
  • AMFEBUTAMONE HCl
  • Bupropion SR
  • Bupropion (INN)
Show all 33 synonyms
  • 1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone
  • Bupropion (R)-Isomer
  • Bupropion (USAN)
  • 1-(3-Chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone
  • Zyban (Salt/Mix)
  • Budeprion (Salt/Mix)
  • Amfebutamone(Bupropion)
  • Wellbutrin (Salt/Mix)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Pale yellow oilexp.
Boiling point
52 °Cexp.
Solubility
Very hygroscopic and susceptible to decompositionexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
239.75 g/molcalc.
Exact mass
239.1077 Dacalc.
LogP (octanol/water)
3.3calc.
Topological polar surface area
29.1 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
3calc.
Heavy atoms
16calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.46calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Bupropion suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 40 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

40 suppliers in 13 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Bupropion price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Antidepressive Agents, Second-Generation, Dopamine Uptake Inhibitors.

Use classes: Pharmaceuticals.

Industries and functions

Pharmacological actions

  • Antidepressive Agents, Second-Generation
  • Cytochrome P-450 CYP2D6 Inhibitors
  • Dopamine Uptake Inhibitors
  • Smoking Cessation Agents

Roles

  • anti-anaemic agent
  • anti-obesity agent
  • antidepressant
  • antineoplastic agent
  • antipsychotic agent
  • anxiolytic drug
  • central nervous system depressant
  • central nervous system drug
  • environmental contaminant
  • hypoglycemic agent
  • pharmaceutical
  • psychotropic drug
  • tranquilizing drug
  • xenobiotic

Functional uses

  • Pharmaceutical

Pharmacology

Bupropion is an Aminoketone. The mechanism of action of bupropion is as a Dopamine Uptake Inhibitor and Norepinephrine Uptake Inhibitor. The physiologic effect of bupropion is by means of Increased Dopamine Activity and Increased Norepinephrine Activity.

How it is made

M-Chlorobenzonitrile is reacted with ethyl Grignard reagent in ether to produce m-chlorobenzyl ethyl ketone, which is brominated in dichloromethane. The product is reacted with tertiary butyl amine in acetonitrile to yield bupropion base. Treatment of an ethereal solution of the base with dry HCl yields the salt.

Preparation: N. B. Mehta, D. A. Yeowell, German patent 2059618 (1971 to Wellcome Found.), N. B. Mehta, United States of America patent 3819706 (1974 to Burroughs Wellcome).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Bupropion is traded under.

HS 2922.39Indicative HS code

Amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than…

World exports in 2024
$187M
−0.3% vs 2023, imports $159M
2019 to 2024
Top exporters
  1. China35.3%
  2. India * partner reported27.7%
  3. Germany12.7%
Top importers
  1. Germany17.3%
  2. United States13.8%
  3. India * partner reported9.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Bupropion is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Bupropion, based on the data on this page

What is Bupropion?

Bupropion is an aromatic ketone that is propiophenone carrying a tert-butylamino group at position 2 and a chloro substituent at position 3 on the phenyl ring. It has a role as an antidepressant, a xenobiotic and an environmental contaminant.

What is the CAS number of Bupropion?

The CAS registry number of Bupropion is 34911-55-2. Other or deprecated CAS numbers: 34841-39-9.

What is the molecular formula and weight of Bupropion?

The molecular formula of Bupropion is C13H18ClNO and its molar mass is 239.75 g/mol.

What is Bupropion used for?

Antidepressive Agents, Second-Generation, Dopamine Uptake Inhibitors. Use classes: Pharmaceuticals.

Is Bupropion hazardous?

Bupropion carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Bupropion?

Bupropion is usually classified under HS code 292239 (Amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Bupropion?

CompoundList lists 40 suppliers of Bupropion in China, United States, Spain, Hong Kong and 9 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Bupropion in India?

2 suppliers in India list Bupropion on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Bupropion?

Suppliers quote Bupropion on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Bupropion

Get quotes for Bupropion

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Bupropion
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Bupropion with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/bupropion-34911-55-2" title="Bupropion structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Central nervous system drugs or HS code 292239

40 suppliers
Free quotes, contact stays private
Get quotes