Carmustine
Also known as 1,3-Bis(2-chloroethyl)-1-nitrosourea, BCNU, Carmustin
Key facts
What buyers check first
- Appearance
- Light yellow powder
- Melting point
- 31 °C
- Solubility
- Highly soluble in alcohol and poorly soluble in water. It is also highly soluble in lipids
- HS code
- 292419
- Category
- Oncology and immunology drugs
- UN number
- UN 2811

What is Carmustine?
Plain description, key identifiers and synonyms
Carmustine is a member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group. It has a role as an alkylating agent and an antineoplastic agent. It is an organochlorine compound and a member of N-nitrosoureas.
Identifiers
Registry numbers, names and line notations, tap to copy
- IUPAC name
- 1,3-bis(2-chloroethyl)-1-nitrosourea
- CAS number
- 154-93-8 CAS number cross-checked
- EC number
- 205-838-2
- Molecular formula
- C5H9Cl2N3O2
- UNII
- U68WG3173Y
- MDL number
- MFCD00057706
- InChIKey
- DLGOEMSEDOSKAD-UHFFFAOYSA-N
- InChI
- InChI=1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)
- SMILES (canonical and isomeric)
- C(CCl)NC(=O)N(CCCl)N=O
Synonyms
- 1,3-Bis(2-chloroethyl)-1-nitrosourea
- BCNU
- Carmustin
- Nitrumon
- Carmubris
- BiCNU
- Becenun
- Bischloroethyl nitrosourea
- Carmustina
- Carmustinum
- Bischlorethylnitrosurea
- N,N'-Bis(2-chloroethyl)-N-nitrosourea
- Bischlorethylnitrosourea
- Becenum
- Urea, N,N'-bis(2-chloroethyl)-N-nitroso-
- FIVB
- Bischloroethylnitrosourea
- FDA 0345
- SRI 1720
- SK 27702
- Camustine
- Carustine
- 1,3-Bis(beta-chloroethyl)-1-nitrosourea
- 1,3-bis(2-chloroethyl)-3-nitrosourea
- Urea, 1,3-bis(2-chloroethyl)-1-nitroso-
Show all 38 synonymsShow fewer synonyms
- bis-chloroethylnitrosourea
- Nitrourean
- bis(chloroethyl) nitrosourea
- Bis-Chloronitrosourea
- Gliadel
- 1,3-Bis(2-chloroethyl)nitrosourea
- Bi CNU
- Bis(2-chloroethyl)nitrosourea
- BiCNU (TN)
- Carmustine (98%)
- Bis(chloroethyl)nitrosourea
- DTI 015
- Bis-N,N'-(chloroethyl)nitrosourea
Physical and chemical properties
Measured values and descriptors computed from the structure
Physical and chemical properties
Measured values, check the supplier specification for your grade
| Appearance | Light yellow powderexp.Measured value |
|---|---|
| Melting point | 31 °Cexp.Measured value |
| Solubility | Highly soluble in alcohol and poorly soluble in water. It is also highly soluble in lipidsexp.Measured value |
Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.
Computed descriptors
Calculated from the structure, useful for screening and formulation
| Molecular weight | 214.05 g/molcalc.Computed value |
|---|---|
| Exact mass | 213.0072 Dacalc.Computed value |
| LogP (octanol/water) | 1.16calc.Computed value |
| Topological polar surface area | 61.77 Ųcalc.Computed value |
| Hydrogen bond donors | 1calc.Computed value |
| Hydrogen bond acceptors | 3calc.Computed value |
| Rotatable bonds | 5calc.Computed value |
| Heavy atoms | 12calc.Computed value |
| Rings | 0calc.Computed value |
| Aromatic rings | 0calc.Computed value |
| Fraction sp3 carbons | 0.8calc.Computed value |
| Formal charge | 0calc.Computed value |
| Stereocentres | 0calc.Computed value |
| Lipinski rule of five | Passes (0 violations)calc.Computed value |
Calculated for screening. Confirm critical figures with the supplier.
Safety and hazards
GHS classification summary, not a safety data sheet
Hazard statements
- H300Fatal if swallowed.
- H350May cause cancer.
- H360May damage fertility or the unborn child.
Precautionary statements (10)
- P203Obtain, read and follow all safety instructions before use.
- P264Wash skin thoroughly after handling.
- P270Do not eat, drink or smoke when using this product.
- P280Wear protective gloves, protective clothing, eye protection and face protection.
- P301 + P316If swallowed: Get emergency medical help immediately.
- P318If exposed or concerned, get medical advice.
- P321Specific treatment (see supplemental first aid instructions on the label).
- P330Rinse mouth.
- P405Store locked up.
- P501Dispose of contents and container in accordance with local regulations.
- UN number
- UN 2811
GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.
Full safety data and first aidCarmustine suppliers
Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings
- India, Ahmedabad ManufacturerUnclaimed profileCarmustineGrade, purity and minimum order on requestPrice on request
- Italy, MilanoUnclaimed profileCarmustineGrade, purity and minimum order on requestPrice on request
- Price on request
- India, MumbaiUnclaimed profileCarmustineGrade, purity and minimum order on requestPrice on request
- ChinaUnclaimed profileCarmustineGrade, purity and minimum order on requestPrice on request
- India, Medchal Malkajgiri ManufacturerUnclaimed profileCarmustineGrade, purity and minimum order on requestPrice on request
- China, Shanghai ManufacturerUnclaimed profileCarmustineGrade, purity and minimum order on requestPrice on request
- Price on request
- United States ManufacturerUnclaimed profileCarmustineGrade, purity and minimum order on requestPrice on request
- Singapore, Singapore ManufacturerUnclaimed profileCarmustineGrade, purity and minimum order on requestPrice on request
Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.
Where suppliers are based
130 suppliers in 17 countries
- China42
- United States38
- India16
- Germany6
- United Kingdom6
- Spain3
- and 11 more countries
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Carmustine price
Indicative price range per kg from live supplier offers
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Uses and applications
What the substance is used for, by industry and function
Medication to treat cancer of the lymph system, cancerous brain tumors, and a certain type of bone marrow cancer.
Therapeutic category: Antineoplastic.
Industries and functions
Pharmacological actions
- Antineoplastic Agents, Alkylating
Roles
- aetiopathogenetic role
- alkylating agent
- anti-inflammatory agent
- antineoplastic agent
- genotoxin
- immunomodulator
- immunosuppressive agent
- mutagen
- pharmaceutical
Pharmacology
Carmustine is an Alkylating Drug. The mechanism of action of carmustine is as an Alkylating Activity.
How it is made
/Carmustine/ may be synthesized by nitrosation with sodium nitrite of the appropriate substituted uera - in this case 1,3-bis(2-chloroethyl)urea - in a cold, acid medium (e.g., formic acid).
Regulatory status
Inventories, regulations and trade controls that list this substance
Health and food
- Active ingredient in FDA approved drug labels
HS code and trade data
Customs classification and reported world trade statistics
Global trade
World import and export statistics for the HS code Carmustine is traded under.
Acyclic amides (including acyclic carbamates) and their derivatives, salts thereof, other
- United States17.5%
- Germany8.8%
- India * partner reported6.7%
* Partner reported figures, a lower bound.
The HS code shown for Carmustine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.
Frequently asked questions
Quick answers about Carmustine, based on the data on this page
What is Carmustine?
What is the CAS number of Carmustine?
What is the molecular formula and weight of Carmustine?
What is Carmustine used for?
Is Carmustine hazardous?
What is the HS code of Carmustine?
Where can I buy Carmustine?
Where can I buy Carmustine in India?
What is the price of Carmustine?
Guides for buyers
Practical guides that help when you source, ship or handle Carmustine
- Article, QualityPharma grades explained: IP vs BP vs USP vs EPWhat the Indian, British, US and European pharmacopoeias are, how their monographs differ, what multi grade claims mean and why a grade alone does not make a product fit for medicines.Read
- Guide, SafetyHow to read a safety data sheet in 10 minutesA section by section method to pull the essentials out of any 16 section SDS: identity, hazards, composition, storage, PPE, properties, transport and emergency measures.Read
- Guide, Trade and logisticsShipping dangerous goods: UN numbers, classes and packing groupsHow the UN dangerous goods system works for chemicals, from the nine classes and UN numbers to packing groups, UN packaging marks, labels, documents and segregation.Read
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