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Cosmetic antioxidants

Carnosic acid

Also known as Salvin, 11,12-dihydroxyabieta-8,11,13-trien-20-oic acid, (4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-4a-carboxylic acid

CAS 3650-09-7Formula C20H28O4Molar mass 332.44 g/molEC 609-253-7
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Carnosic acid chemical structure, C20H28O4, CAS 3650-09-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
3650-09-7
Formula
C20H28O4
Molar mass
332.44 g/mol
EC number
609-253-7
HS code
291829
Category
Cosmetic antioxidants

What is Carnosic acid?

Plain description, key identifiers and synonyms

Carnosic acid is an abietane diterpenoid that is abieta-8,11,13-triene substituted by hydroxy groups at positions 11 and 12 and a carboxy group at position 20. It is isolated from rosemary (Rosmarinus officinalis) and common sage (Salvia officinalis) and exhibits anti-angiogenic, antineoplastic, antioxidant and anti-HIV activity. It has a role as an antioxidant, an antineoplastic agent, a HIV protease inhibitor, an angiogenesis modulating agent, a food preservative, an anti-inflammatory agent, an apoptosis inducer and a plant metabolite. It is a monocarboxylic acid, a member of catechols, an abietane diterpenoid and a carbotricyclic compound. It is a conjugate acid of a carnosate.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-4a-carboxylic acid
CAS number
3650-09-7 CAS number cross-checkedOther or deprecated CAS: 139236-75-2
EC number
609-253-7
Molecular formula
C20H28O4
UNII
LI791SXT24
MDL number
MFCD02259459
INCI name
CARNOSIC ACID
InChIKey
QRYRORQUOLYVBU-VBKZILBWSA-N
InChI
InChI=1S/C20H28O4/c1-11(2)13-10-12-6-7-14-19(3,4)8-5-9-20(14,18(23)24)15(12)17(22)16(13)21/h10-11,14,21-22H,5-9H2,1-4H3,(H,23,24)/t14-,20+/m0/s1
Canonical SMILES
CC(C)c1cc2c(c(O)c1O)C1(C(=O)O)CCCC(C)(C)C1CC2
Isomeric SMILES
CC(C)C1=C(C(=C2C(=C1)CC[C@@H]3[C@@]2(CCCC3(C)C)C(=O)O)O)O

Synonyms

  • Salvin
  • 11,12-dihydroxyabieta-8,11,13-trien-20-oic acid
  • (4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-4a-carboxylic acid
  • 4a(2H)-Phenanthrenecarboxylic acid, 1,3,4,9,10,10a-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4aR,10aS)-
  • Carnosic acid (Standard)
  • (4aR,10aS)-5,6-Dihydroxy-7-isopropyl-1,1-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-4a-carboxylic Acid
  • 4a(2H)-Phenanthrenecarboxylic acid, 1,3,4,9,10,10a-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4aR-trans)-
  • RoseOx
  • 11,12-dihydroxy-13-isopropylpodocarpa-8,11,13-trien-17-oic acid
  • Carnosic acid from Rosmarinus officinalis
  • (4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-(propan-2-yl)-1,3,4,9,10,10a-hexahydrophenanthrene-4a(2H)-carboxylic acid
  • Carnosic acid, Free acid
  • Rosamox
  • Carnosic-acid
  • Carnosic acid, analytical standard
  • (4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-4a-carboxylic acid
  • Carnosic acid (constituent of rosemary)
  • Carnosic acid, primary pharmaceutical reference standard
  • Carnosic acid from Rosmarinus officinalis, >=91%, powder
  • Carnosic acid, United States Pharmacopeia (USP) Reference Standard
  • Natural diterpenoid resorcinol isolated from Rosmarinus officinalis.
  • Podocarpa-8,11,13-trien-17-oic acid, 11,12-dihydroxy-13-isopropyl-
  • (4Ar,10as)-1,3,4,9,10,10a-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-4a(2H)-phenanthrenecarboxylic acid
  • (4aR,10aS)-5,6-Dihydroxy-7-isopropyl-1,1-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-4a-carboxy
  • (4aR,10aS)-5,6-dihydroxy-7-isopropyl-1,1-dimethyl-1,3,4,9,10,10a-hexahydrophenanthrene-4a(2H)-carboxylic acid
Show all 26 synonyms
  • (4aR,10aS)-5,6-dihydroxy-7-isopropyl-1,1-dimethyl-2,3,4,9,10,10a-hexahydrophenanthrene-4a-carboxylic acid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
332.44 g/molcalc.
Exact mass
332.1988 Dacalc.
LogP (octanol/water)
4.32calc.
Topological polar surface area
77.76 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
2calc.
Heavy atoms
24calc.
Rings
3calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.65calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)CCC1CCCCC21

c1ccc2c(c1)CCC1CCCCC21

3 rings, 14 atoms, the 1,2,3,4,4a,9,10,10a-Octahydrophenanthrene ring system.

259 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Carnosic acid suppliers

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All 25 suppliers
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Where suppliers are based

25 suppliers in 5 countries

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Carnosic acid price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name CARNOSIC ACID(antioxidant)

Pharmacological actions

  • Anti-Infective Agents, Local
  • Antioxidants

Roles

  • HIV protease inhibitor
  • additive
  • angiogenesis modulating agent
  • anti-HIV agent
  • anti-inflammatory agent
  • antimicrobial agent
  • antineoplastic agent
  • antioxidant
  • antiviral agent
  • apoptosis inducer
  • enzyme inhibitor
  • eukaryotic metabolite
  • food additive
  • food component
  • food preservative
  • metabolite
  • pharmaceutical
  • physiological role
  • plant metabolite
  • protease inhibitor

Functional uses

  • Antioxidant

Cosmetic functions

  • Antioxidant

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Carnosic acid is traded under.

HS 2918.29Indicative HS code

Carboxylic acids, (with phenol function but without other oxygen function), their anhydrides, halides…

World exports in 2024
$861M
+0.9% vs 2023, imports $892M
2019 to 2024
Top exporters
  1. China30.5%
  2. South Korea18.3%
  3. Switzerland * partner reported13.3%
Top importers
  1. United States14.7%
  2. Germany13.3%
  3. Japan10.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Carnosic acid is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Carnosic acid, based on the data on this page

What is Carnosic acid?

Carnosic acid is an abietane diterpenoid that is abieta-8,11,13-triene substituted by hydroxy groups at positions 11 and 12 and a carboxy group at position 20.

What is the CAS number of Carnosic acid?

The CAS registry number of Carnosic acid is 3650-09-7. Other or deprecated CAS numbers: 139236-75-2.

What is the molecular formula and weight of Carnosic acid?

The molecular formula of Carnosic acid is C20H28O4 and its molar mass is 332.44 g/mol.

What is Carnosic acid used for?

Known uses and roles of Carnosic acid include antioxidants in cosmetics and personal care, preservatives in food and beverage, disinfectants in home care and cleaning, hiv protease inhibitor, additive and 20 more.

Is Carnosic acid hazardous?

No GHS hazard classification for Carnosic acid is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Carnosic acid?

Carnosic acid is usually classified under HS code 291829 (Carboxylic acids with phenol function but without other oxygen function, their…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Carnosic acid?

CompoundList lists 25 suppliers of Carnosic acid in China, India, United States, Spain and 1 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Carnosic acid in India?

2 suppliers in India list Carnosic acid on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Carnosic acid?

Suppliers quote Carnosic acid on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Carnosic acid

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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