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Impurities and reference standards

Cedazuridine

Also known as Cedazuridina, (4R)-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one, (4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine

CAS 1141397-80-9Formula C9H14F2N2O5Molar mass 268.22 g/molEC 822-329-6
GHS signal word: Warning. Pictograms: Harmful or irritant, Serious health hazard 3 suppliers listed
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Cedazuridine chemical structure, C9H14F2N2O5, CAS 1141397-80-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1141397-80-9
Formula
C9H14F2N2O5
Molar mass
268.22 g/mol
EC number
822-329-6
HS code
293499
Category
Impurities and reference standards

What is Cedazuridine?

Plain description, key identifiers and synonyms

Cedazuridine is an orally available synthetic nucleoside analog derived from tetrahydrouridine (THU) and cytidine deaminase inhibitor (CDAi), that can potentially be used to prevent the breakdown of cytidines. Upon oral administration, cedazuridine binds to and inhibits CDA, an enzyme primarily found in the gastrointestinal (GI) tract and liver that catalyzes the deamination of cytidine and cytidine analogs. Given in combination with a cytidine, such as the antineoplastic hypomethylating agent decitabine, it specifically prevents its breakdown and increases its bioavailability and efficacy. In addition, this allows for lower doses of decitabine to be administered, which results in decreased decitabine-associated GI toxicity.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(4R)-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one
CAS number
1141397-80-9
EC number
822-329-6
Molecular formula
C9H14F2N2O5
UNII
39IS23Q1EW
MDL number
MFCD32062663
InChIKey
VUDZSIYXZUYWSC-DBRKOABJSA-N
InChI
InChI=1S/C9H14F2N2O5/c10-9(11)6(16)4(3-14)18-7(9)13-2-1-5(15)12-8(13)17/h4-7,14-16H,1-3H2,(H,12,17)/t4-,5-,6-,7-/m1/s1
Canonical SMILES
O=C1NC(O)CCN1C1OC(CO)C(O)C1(F)F
Isomeric SMILES
C1CN(C(=O)N[C@@H]1O)[C@H]2C([C@@H]([C@H](O2)CO)O)(F)F

Synonyms

  • Cedazuridina
  • (4R)-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one
  • (4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine
  • Inqovi component cedazuridine
  • Astx727 component cedazuridine
  • Astx-727 component cedazuridine
  • Uridine, 2'-deoxy-2',2'-difluoro-3,4,5,6-tetrahydro-, (4R)-
  • cedazuridinum
  • (4R)-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl)-4-hydroxy-1,3-diazinan-2-one
  • CDA Inhibitor E7727
  • Uridine, 2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydro-, (4R)
  • (R)-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxytetrahydropyrimidin-2(1H)-one
  • Cedazuridine?
  • (R)-1-[(2R,4R,5R)-3,3-Difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-4-hydroxytetrahydropyrimidin-2(1H)-one
  • Cedazuridine Impurity 2
  • Cedazuridine (USAN/INN)
  • WHO 10741
  • ASTX727 (cedazuridine + decitabine)
  • compound 7a
  • Cedazuridine component of astx727
  • Cedazuridine component of astx-727
  • (4R)-2'-deoxy-2',2'-difluoro-3,4,5,6-tetrahydro-Uridine
  • Cedazuridine(4R)-2\'-Deoxy-2\',2\'-difluoro-3,4,5,6-tetrahydrouridine
  • (4R)-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-4-hydroxy-hexahydropyrimidin-2-one

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
268.22 g/molcalc.
Exact mass
268.0871 Dacalc.
LogP (octanol/water)
-1.57calc.
Topological polar surface area
102.3 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
2calc.
Heavy atoms
18calc.
Rings
2calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.89calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1NCCCN1C1CCCO1

O=C1NCCCN1C1CCCO1

2 rings, 12 atoms.

6 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302 + H332Harmful if swallowed. Harmful if inhaled.
  • H302Harmful if swallowed.
  • H341Suspected of causing genetic defects.
  • H373May cause damage to organs through prolonged or repeated exposure.
Precautionary statements (15)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Cedazuridine suppliers

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All 3 suppliers

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Where suppliers are based

3 suppliers in 3 countries

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Cedazuridine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Pharmacology

Cedazuridine is a small molecule inhibitor of cytidine deaminase that is used as a pharmacoenhancer of decitabine to increase oral bioavailability of this DNA methylase inhibitor treatment of myelodysplastic syndromes. The combination of oral decitabine and cedazuridine is associated with a low rate of minor serum enzyme elevations during therapy that is usually attributed to decitabine. The oral combination has not been linked to cases of clinically apparent liver injury.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Cedazuridine is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Cedazuridine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Cedazuridine, based on the data on this page

What is Cedazuridine?

Cedazuridine is an orally available synthetic nucleoside analog derived from tetrahydrouridine (THU) and cytidine deaminase inhibitor (CDAi), that can potentially be used to prevent the breakdown of cytidines.

What is the CAS number of Cedazuridine?

The CAS registry number of Cedazuridine is 1141397-80-9.

What is the molecular formula and weight of Cedazuridine?

The molecular formula of Cedazuridine is C9H14F2N2O5 and its molar mass is 268.22 g/mol.

What is Cedazuridine used for?

Known uses and roles of Cedazuridine include antineoplastic agent and pharmaceutical.

Is Cedazuridine hazardous?

Cedazuridine carries the GHS signal word "Warning". Main hazards: harmful if swallowed. harmful if inhaled, harmful if swallowed, suspected of causing genetic defects. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Cedazuridine?

Cedazuridine is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Cedazuridine?

CompoundList lists 3 suppliers of Cedazuridine in China, Taiwan and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Cedazuridine?

Suppliers quote Cedazuridine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Cedazuridine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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