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Screening compounds

Cemsidomide

Also known as (3S)-3-(6-((4-(Morpholin-4-ylmethyl)phenyl)methyl)-2-oxobenzo(cd)indol-1-yl)piperidine-2,6-dione, (3S)-3-[6-[[4-(morpholin-4-ylmethyl)phenyl]methyl]-2-oxobenzo[cd]indol-1-yl]piperidine-2,6-dione, 2,6-Piperidinedione, 3-(6-((4-(4-morpholinylmethyl)phenyl)methyl)-2-oxobenz(cd)indol-1(2H)-yl)-, (3S)-

CAS 2504235-67-8Formula C28H27N3O4Molar mass 469.54 g/mol
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Cemsidomide chemical structure, C28H27N3O4, CAS 2504235-67-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
2504235-67-8
Formula
C28H27N3O4
Molar mass
469.54 g/mol
HS code
293499
Category
Screening compounds

What is Cemsidomide?

Plain description, key identifiers and synonyms

Cemsidomide is an orally bioavailable modulator of the E3 ubiquitin ligase complex containing cereblon (CRL4-CRBN E3 ubiquitin ligase), with potential immunomodulating and antineoplastic activities. Upon oral administration, cemsidomide specifically binds to cereblon (CRBN), thereby affecting the ubiquitin E3 ligase activity, and targeting certain substrate proteins for ubiquitination. This induces proteasome-mediated degradation of certain transcription factors, including Ikaros (IKZF1) and Aiolos (IKZF3), which are transcriptional repressors in T-cells. This reduces the levels of these transcription factors, and modulates the activity of the immune system, which may include the activation of T-lymphocytes. This also leads to downregulation of the activity of other proteins, some of which play key roles in the proliferation of certain cancer cell types. CRBN, the substrate recognition component of the CRL4-CRBN E3 ubiquitin ligase complex, plays a key role in the ubiquitination of certain proteins.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(3S)-3-[6-[[4-(morpholin-4-ylmethyl)phenyl]methyl]-2-oxobenzo[cd]indol-1-yl]piperidine-2,6-dione
CAS number
2504235-67-8
Molecular formula
C28H27N3O4
UNII
D86MF5H9WJ
MDL number
MFCD34662949
InChIKey
MUKCJOOKCZSQNW-DEOSSOPVSA-N
InChI
InChI=1S/C28H27N3O4/c32-25-11-10-24(27(33)29-25)31-23-9-8-20(21-2-1-3-22(26(21)23)28(31)34)16-18-4-6-19(7-5-18)17-30-12-14-35-15-13-30/h1-9,24H,10-17H2,(H,29,32,33)/t24-/m0/s1
Canonical SMILES
O=C1CCC(N2C(=O)c3cccc4c(Cc5ccc(CN6CCOCC6)cc5)ccc2c34)C(=O)N1
Isomeric SMILES
C1CC(=O)NC(=O)[C@H]1N2C3=C4C(=C(C=C3)CC5=CC=C(C=C5)CN6CCOCC6)C=CC=C4C2=O

Synonyms

  • (3S)-3-(6-((4-(Morpholin-4-ylmethyl)phenyl)methyl)-2-oxobenzo(cd)indol-1-yl)piperidine-2,6-dione
  • (3S)-3-[6-[[4-(morpholin-4-ylmethyl)phenyl]methyl]-2-oxobenzo[cd]indol-1-yl]piperidine-2,6-dione
  • 2,6-Piperidinedione, 3-(6-((4-(4-morpholinylmethyl)phenyl)methyl)-2-oxobenz(cd)indol-1(2H)-yl)-, (3S)-
  • 2,6-Piperidinedione, 3-[6-[[4-(4-morpholinylmethyl)phenyl]methyl]-2-oxobenz[cd]indol-1(2H)-yl]-, (3S)-
  • (S)-3-(6-(4-(Morpholinomethyl)benzyl)-2-oxobenzo[cd]indol-1(2H)-yl)piperidine-2,6-dione
  • Cemsidomida
  • (S)-3-[6-[4-(Morpholinomethyl)benzyl]-2-oxobenzo[cd]indol-1(2H)-yl]piperidine-2,6-dione
  • CFT7455, Cemsidomide
  • Cemisidomide (USAN/INN)
  • Cft 7455
  • (S)-CFT7455
  • (3S)-3-(6-{[4-(morpholin-4-ylmethyl)phenyl]methyl}-2-oxobenz[cd]indol-1(2H)-yl]piperidine-2,6-dione
  • (3S)-3-[6-[[4-(4-Morpholinylmethyl)phenyl]methyl]-2-oxobenz[cd]indol-1(2H)-yl]-2,6-piperidinedione
  • (3S)-3-[6-[[4-(morpholinomethyl)phenyl]methyl]-2-oxo-benzo[cd]indol-1-yl]piperidine-2,6-dione
  • (3S)-3-[9-({4-[(morpholin-4-yl)methyl]phenyl}methyl)-3-oxo-2-azatricyclo[6.3.1.0,4,12]dodeca-1(12),4,6,8,10-pentaen-2-yl]piperidine-2,6-dione

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
469.54 g/molcalc.
Exact mass
469.2002 Dacalc.
LogP (octanol/water)
3.03calc.
Topological polar surface area
78.95 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
5calc.
Heavy atoms
35calc.
Rings
6calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.32calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCC(N2C(=O)c3cccc4c(Cc5ccc(CN6CCOCC6)cc5)ccc2c34)C(=O)N1

O=C1CCC(N2C(=O)c3cccc4c(Cc5ccc(CN6CCOCC6)cc5)ccc2c34)C(=O)N1

6 rings, 35 atoms, the (rac)-Cemsidomide ring system.

2 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Cemsidomide suppliers

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Where suppliers are based

1 supplier in 1 country

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Cemsidomide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Cemsidomide is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Cemsidomide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Cemsidomide, based on the data on this page

What is Cemsidomide?

Cemsidomide is an orally bioavailable modulator of the E3 ubiquitin ligase complex containing cereblon (CRL4-CRBN E3 ubiquitin ligase), with potential immunomodulating and antineoplastic activities.

What is the CAS number of Cemsidomide?

The CAS registry number of Cemsidomide is 2504235-67-8.

What is the molecular formula and weight of Cemsidomide?

The molecular formula of Cemsidomide is C28H27N3O4 and its molar mass is 469.54 g/mol.

What is Cemsidomide used for?

Known uses and roles of Cemsidomide include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent and pharmaceutical.

Is Cemsidomide hazardous?

No GHS hazard classification for Cemsidomide is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Cemsidomide?

Cemsidomide is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Cemsidomide?

CompoundList lists 1 supplier of Cemsidomide in United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Cemsidomide?

Suppliers quote Cemsidomide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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