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Analgesics and anti-inflammatories

Chloroquine

Also known as Aralen, Chloraquine, Chlorochin

CAS 54-05-7Formula C18H26ClN3Molar mass 319.88 g/molEC 200-191-2
GHS signal word: Warning. Pictograms: Harmful or irritant 88 suppliers listed Drug substance
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Chloroquine chemical structure, C18H26ClN3, CAS 54-05-7
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
White to slightly yellow, crystalline powder
Melting point
87 °C
Solubility
Bitter colorless crystals, dimorphic. Freely soluble in water, less sol in neutral or al…
HS code
293349
Category
Analgesics and anti-inflammatories
Illustrative photo, off-white crystalline powder in an HDPE jar on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Chloroquine?

Plain description, key identifiers and synonyms

Chloroquine is an aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis. It has a role as an anticoronaviral agent, an antirheumatic drug, an antimalarial, a dermatologic drug and an autophagy inhibitor. It is an organochlorine compound, an aminoquinoline, a secondary amino compound and a tertiary amino compound. It is a conjugate base of a chloroquine(2+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine
CAS number
54-05-7 CAS number cross-checkedOther or deprecated CAS: 117399-83-4
EC number
200-191-2
Molecular formula
C18H26ClN3
UNII
886U3H6UFF
MDL number
MFCD00024009
InChIKey
WHTVZRBIWZFKQO-UHFFFAOYSA-N
InChI
InChI=1S/C18H26ClN3/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21)
SMILES (canonical and isomeric)
CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl

Synonyms

  • Aralen
  • Chloraquine
  • Chlorochin
  • Artrichin
  • Chloroquina
  • Reumachlor
  • Chloroquinium
  • Capquin
  • Chlorquin
  • Arthrochin
  • Bipiquin
  • Clorochina
  • Gontochin
  • Klorokin
  • Mesylith
  • Trochin
  • Amokin
  • Chingamin
  • Cloroquina
  • Sanoquin
  • Nivaquine B
  • Bemaphate
  • Khingamin
  • Resoquine
  • Chlorochine
Show all 39 synonyms
  • Chlorochinum
  • Chloroquinum
  • RP 3377
  • 7-Chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline
  • 4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine
  • 7-Chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline
  • N4-(7-Chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine
  • SN 7618
  • Quinoline, 7-chloro-4-((4-(diethylamino)-1-methylbutyl)amino)-
  • 1,4-Pentanediamine, N(4)-(7-chloro-4-quinolinyl)-N(1),N(1)-diethyl-
  • Chingaminum
  • Arechine
  • N'-(7-chloroquinolin-4-yl)-N,N-diethylpentane-1,4-diamine
  • 7-Chloro-N-[5-(diethylamino)pentan-2-yl]quinolin-4-amine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White to slightly yellow, crystalline powderexp.
Odour
ODORLESSexp.
Taste
Bitter tasteexp.
Melting point
87 °Cexp.
Solubility
Bitter colorless crystals, dimorphic. Freely soluble in water, less sol in neutral or alkaline pH. Stable to heat in soln pH4 to 6.5. Practically in soluble in alcohol, benzene and chloroform /Diphosphate/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
319.88 g/molcalc.
Exact mass
319.1815 Dacalc.
LogP (octanol/water)
4.81calc.
Topological polar surface area
28.16 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
8calc.
Heavy atoms
22calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.5calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2ncccc2c1

c1ccc2ncccc2c1

2 rings, 10 atoms, the Quinoline ring system.

21,766 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Chloroquine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 88 suppliers
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Where suppliers are based

88 suppliers in 18 countries

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Chloroquine price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Antimalarial, antiamebic, antitheuratic, Lupus erthematus supressant.

Mesh Heading: Amebicides, antimalarials, antirheumatic Agents.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Amebicides
  • Antimalarials
  • Antirheumatic Agents

Roles

  • anti-HIV agent
  • anti-anaemic agent
  • anticoronaviral agent
  • antiinfective agent
  • antimalarial
  • antimicrobial agent
  • antimicrobial drug
  • antineoplastic agent
  • antiparasitic agent
  • antiplasmodial drug
  • antiprotozoal drug
  • antirheumatic drug
  • antiviral agent
  • autophagy inhibitor
  • dermatologic drug
  • pharmaceutical

Pharmacology

Chloroquine is an Antimalarial.

How it is made

H. Andersag et al., US 2233970 (1941 to Winthrop)

Condensation of 4,7-dichloroquinoline with 1-diethylamino-4-aminopentane: German patent 683692 (1939).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Chloroquine is traded under.

HS 2933.49Indicative HS code

Compounds containing in the structure a quinoline or isoquinoline ring-system (whether…

World exports in 2024
$939M
−14.6% vs 2023, imports $1.48B
2019 to 2024
Top exporters
  1. China30.1%
  2. India * partner reported16.7%
  3. Switzerland * partner reported14.1%
Top importers
  1. United Kingdom19.2%
  2. Germany16.0%
  3. Romania8.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Chloroquine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Chloroquine, based on the data on this page

What is Chloroquine?

Chloroquine is an aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.

What is the CAS number of Chloroquine?

The CAS registry number of Chloroquine is 54-05-7. Other or deprecated CAS numbers: 117399-83-4.

What is the molecular formula and weight of Chloroquine?

The molecular formula of Chloroquine is C18H26ClN3 and its molar mass is 319.88 g/mol.

What is Chloroquine used for?

Antimalarial, antiamebic, antitheuratic, Lupus erthematus supressant. Mesh Heading: Amebicides, antimalarials, antirheumatic Agents. Use classes: Pharmaceuticals.

Is Chloroquine hazardous?

Chloroquine carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Chloroquine?

Chloroquine is usually classified under HS code 293349 (Compounds containing in the structure a quinoline or isoquinoline ring-system (whether…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Chloroquine?

CompoundList lists 88 suppliers of Chloroquine in United States, China, India, Germany and 14 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Chloroquine in India?

8 suppliers in India list Chloroquine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Chloroquine?

Suppliers quote Chloroquine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Chloroquine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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