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Cardiovascular and metabolic drugs

Chlorthalidone

Also known as Chlortalidone, Phthalamudine, Hygroton

CAS 77-36-1Formula C14H11ClN2O4SMolar mass 338.77 g/molEC 201-022-5
GHS signal word: Warning. Pictograms: Harmful or irritant 123 suppliers listed Drug substance
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Chlorthalidone chemical structure, C14H11ClN2O4S, CAS 77-36-1
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from 50% acetic acid
Melting point
Dec 224-226 °C. Melting point range may extend from 218 to 264 °C on slow heating.
Solubility
12 mg/100 ml in water @ 20 °C, 27 mg/100 ml @ 37 °C, 577 mg/100 ml in 0.1 N sodium carbo…
HS code
293590
Category
Cardiovascular and metabolic drugs
Illustrative photo, assorted laboratory chemical bottles and jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Chlorthalidone?

Plain description, key identifiers and synonyms

Chlorthalidone is a member of isoindoles, a sulfonamide and a member of monochlorobenzenes.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-chloro-5-(1-hydroxy-3-oxo-2H-isoindol-1-yl)benzenesulfonamide
CAS number
77-36-1 CAS number cross-checkedOther or deprecated CAS: 74658-80-3
EC number
201-022-5
Molecular formula
C14H11ClN2O4S
UNII
Q0MQD1073Q
MDL number
MFCD00036257
InChIKey
JIVPVXMEBJLZRO-UHFFFAOYSA-N
InChI
InChI=1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21)
SMILES (canonical and isomeric)
C1=CC=C2C(=C1)C(=O)NC2(C3=CC(=C(C=C3)Cl)S(=O)(=O)N)O

Synonyms

  • Chlortalidone
  • Phthalamudine
  • Hygroton
  • Chlorphthalidolone
  • Chlorthalidon
  • Phthalamodine
  • Natriuran
  • Thalitone
  • Chlorothalidone
  • Chlorphthalidone
  • Saluretin
  • Igroton
  • Zambesil
  • Isoren
  • Oradil
  • Renon
  • Chlortalidonum
  • Clortalidona
  • Clortalidone
  • 2-Chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)benzenesulfonamide
  • 3-Hydroxy-3-(4-chloro-3-sulfamylphenyl)phthalimidine
  • 3-(4'-Chloro-3'-sulfamoylphenyl)-3-hydroxyphthalimidine
  • 1-Oxo-3-(3-sulfamyl-4-chlorophenyl)-3-hydroxyisoindoline
  • 1-Keto-3-(3'-sulfamyl-4'-chlorophenyl)-3-hydroxyisoindoline
  • 2-chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)benzenesulfonamide
Show all 37 synonyms
  • Benzenesulfonamide, 2-chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-
  • Benzenesulfonamide, 2-chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)-
  • Oxodoline
  • 3-Hydroxy-3-[4-chloro-3-sulfamylphenyl]phthalimidine
  • 2-chloro-5-(1,3-dihydroxy-1H-isoindol-1-yl)benzene-1-sulfonamide
  • Chlorthalidone chlorthalidone
  • Hydro-Long
  • Oxodolin
  • Oksodolin (oxodolin)
  • Racemic chlorthalidone
  • 2-Chloro-5-(1-hydroxy-3-oxoisoindolin-1-yl)benzenesulfonamide
  • 2-chloro-5-(1-hydroxy-3-oxo-2H-isoindol-1-yl)benzenesulfonamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from 50% acetic acidexp.
Melting point
Dec 224-226 °C. Melting point range may extend from 218 to 264 °C on slow heating.exp.
Solubility
12 mg/100 ml in water @ 20 °C, 27 mg/100 ml @ 37 °C, 577 mg/100 ml in 0.1 N sodium carbonate, more sol in aq soln of sodium hydroxide, sol in warm ethanol, slightly sol in ether.exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
338.77 g/molcalc.
Exact mass
338.0128 Dacalc.
LogP (octanol/water)
0.92calc.
Topological polar surface area
109.5 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
2calc.
Heavy atoms
22calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.07calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1NC(c2ccccc2)c2ccccc21

O=C1NC(c2ccccc2)c2ccccc21

3 rings, 16 atoms, the 3-Phenyl-2,3-dihydroisoindol-1-one ring system.

87 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Chlorthalidone suppliers

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All 123 suppliers
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Where suppliers are based

123 suppliers in 18 countries

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Chlorthalidone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Therapeutic category (veterinary): Diuretic.

Therapeutic category: Diuretic, antihypertensive.

Is indicated in the management of hypertension either alone or in combination with other antihypertensive drugs. Chlorthalidone is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteriod and estrogen therapy.

Use classes: Pharmaceuticals.

Industries and functions

Pharmacological actions

  • Antihypertensive Agents
  • Diuretics
  • Sodium Chloride Symporter Inhibitors

Roles

  • antiatherosclerotic agent
  • antihypertensive agent
  • cardiovascular drug
  • hypoglycemic agent
  • pharmaceutical
  • protective agent
  • renoprotective agent

Functional uses

  • Pharmaceutical

Pharmacology

Chlorthalidone is a Thiazide-like Diuretic. The physiologic effect of chlorthalidone is by means of Increased Diuresis.

How it is made

Diazotization of 3-amino-4-chlorobenzophenone-2-carboxylic acid, followed by reaction with sulfur dioxide, then thionyl chloride and ammonia

Graf et al, Helv Chim Acta 42, 1085 (1959), US patent 3,055,904 (1962 to Geigy).

Heating...4-chloro-2'-carboxybenzophenone-3-sulfonyl chloride with thionyl chloride yields 3-chloro-3-(3'-chlor osulfonyl-4'-chlorophenyl)phthalide which is isolated, dissolved in chloroform, & reacted with ammonia...in...ethanol. Removal of solvent & treatment of residue with hcl yields crude chlorthalidone...

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Chlortalidone (INN), Ref no: 262, Annex ref: II/262
  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Chlorthalidone is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Chlorthalidone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Chlorthalidone, based on the data on this page

What is Chlorthalidone?

Chlorthalidone is a member of isoindoles, a sulfonamide and a member of monochlorobenzenes.

What is the CAS number of Chlorthalidone?

The CAS registry number of Chlorthalidone is 77-36-1. Other or deprecated CAS numbers: 74658-80-3.

What is the molecular formula and weight of Chlorthalidone?

The molecular formula of Chlorthalidone is C14H11ClN2O4S and its molar mass is 338.77 g/mol.

What is Chlorthalidone used for?

Therapeutic category (veterinary): Diuretic. Therapeutic category: Diuretic, antihypertensive. Is indicated in the management of hypertension either alone or in combination with other antihypertensive drugs.

Is Chlorthalidone hazardous?

Chlorthalidone carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Chlorthalidone?

Chlorthalidone is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Chlorthalidone?

CompoundList lists 123 suppliers of Chlorthalidone in India, United States, China, Germany and 14 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Chlorthalidone in India?

37 suppliers in India list Chlorthalidone on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Chlorthalidone?

Suppliers quote Chlorthalidone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Chlorthalidone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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