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Murcko scaffold

3-Phenyl-2,3-dihydroisoindol-1-one scaffold

88 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
88
With full pages
8
Scaffold SMILES

O=C1NC(c2ccccc2)c2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3-Phenyl-2,3-dihydroisoindol-1-one page
Murcko scaffold O=C1NC(c2ccccc2)c2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 88 chemicals

Chlorthalidone chemical structure, C14H11ClN2O4S, CAS 77-36-1
Chlorthalidone
CAS 77-36-1C14H11ClN2O4S
2-Chloro-5-(1-hydroxy-3-oxo-2H-isoindol-1-yl)benzenesulfonamide, phthalazin-1-ylhydrazine, 1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)propan-2-ol chemical structure, C37H42ClN7O7S, CAS 90992-24-8
2-Chloro-5-(1-hydroxy-3-oxo-2H-isoindol-1-yl)benzenesulfonamide, phthalazin-1-ylhydrazine, 1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)propan-2-ol
CAS 90992-24-8C37H42ClN7O7S
Uranidil A chemical structure, C20H19Cl2N9O5S, CAS 93281-22-2
Uranidil A
CAS 93281-22-2C20H19Cl2N9O5S
Clonidine and chlorthalidone chemical structure, C23H20Cl3N5O4S, CAS 376634-05-8
Clonidine and chlorthalidone
CAS 376634-05-8C23H20Cl3N5O4S
Ubisindine phosphate chemical structure, C20H27N2O5P, CAS 26070-68-8
Ubisindine phosphate
CAS 26070-68-8C20H27N2O5P
Ubisindine chemical structure, C20H24N2O, CAS 26070-78-0
Ubisindine
CAS 26070-78-0C20H24N2O
Atenolol, chlorthalidone chemical structure, C28H33ClN4O7S, CAS 73677-19-7
Atenolol, chlorthalidone
CAS 73677-19-7C28H33ClN4O7S
3-Hydroxy-3-phenylisoindolin-1-one chemical structure, C14H11NO2, CAS 6637-53-2
3-Hydroxy-3-phenylisoindolin-1-one
CAS 6637-53-2C14H11NO2
2-tert-Butyl-3-hydroxy-3-phenyl-2,3-dihydro-1H-isoindol-1-one chemical structure, C18H19NO2, CAS 3532-74-9
2-tert-Butyl-3-hydroxy-3-phenyl-2,3-dihydro-1H-isoindol-1-one
CAS 3532-74-9C18H19NO2
3-Hydroxy-2-(3-methoxypropyl)-3-phenyl-2,3-dihydro-1H-isoindol-1-one chemical structure, C18H19NO3, CAS 3532-76-1
3-Hydroxy-2-(3-methoxypropyl)-3-phenyl-2,3-dihydro-1H-isoindol-1-one
CAS 3532-76-1C18H19NO3
3-Hydroxy-3-phenyl-2-(prop-2-en-1-yl)-2,3-dihydro-1H-isoindol-1-one chemical structure, C17H15NO2, CAS 3532-75-0
3-Hydroxy-3-phenyl-2-(prop-2-en-1-yl)-2,3-dihydro-1H-isoindol-1-one
CAS 3532-75-0C17H15NO2
3-Phenyl-2,3-dihydroisoindol-1-one chemical structure, C14H11NO, CAS 835-18-7
3-Phenyl-2,3-dihydroisoindol-1-one
CAS 835-18-7C14H11NO
2-(2-Aminoethyl)-3-(4-chlorophenyl)-3-hydroxy-1-isoindolinone chemical structure, C16H15ClN2O2, CAS 5983-84-6
2-(2-Aminoethyl)-3-(4-chlorophenyl)-3-hydroxy-1-isoindolinone
CAS 5983-84-6C16H15ClN2O2
3-(4-Chlorophenyl)-2-ethyl-3-hydroxy-1-isoindolinone chemical structure, C16H14ClNO2, CAS 1031-18-1
3-(4-Chlorophenyl)-2-ethyl-3-hydroxy-1-isoindolinone
CAS 1031-18-1C16H14ClNO2
2-(2-Aminoethyl)-3-hydroxy-3-phenyl-1-isoindolinone chemical structure, C16H16N2O2, CAS 3532-79-4
2-(2-Aminoethyl)-3-hydroxy-3-phenyl-1-isoindolinone
CAS 3532-79-4C16H16N2O2
Chlortalidone, (R)- chemical structure, C14H11ClN2O4S, CAS 1441368-45-1
Chlortalidone, (R)-
CAS 1441368-45-1C14H11ClN2O4S
2-Chloro-5-((1S)-1-hydroxy-3-oxo-2H-isoindol-1-yl)benzenesulfonamide chemical structure, C14H11ClN2O4S, CAS 1441368-51-9
2-Chloro-5-((1S)-1-hydroxy-3-oxo-2H-isoindol-1-yl)benzenesulfonamide
CAS 1441368-51-9C14H11ClN2O4S
1H-Isoindol-1-one, 2,3-dihydro-2-(2-(diethylamino)ethyl)-3-(2-(methylamino)phenyl)- chemical structure, C21H27N3O, CAS 116870-45-2
1H-Isoindol-1-one, 2,3-dihydro-2-(2-(diethylamino)ethyl)-3-(2-(methylamino)phenyl)-
CAS 116870-45-2C21H27N3O
1H-Isoindol-1-one, 2,3-dihydro-3-(2-aminophenyl)-2-(2-(diethylamino)ethyl)-, hydrochloridehydrate (4:8:1) chemical structure, C20H27Cl2N3O, CAS 116870-74-7
1H-Isoindol-1-one, 2,3-dihydro-3-(2-aminophenyl)-2-(2-(diethylamino)ethyl)-, hydrochloridehydrate (4:8:1)
CAS 116870-74-7C20H27Cl2N3O
1H-Isoindol-1-one, 2,3-dihydro-3-(2-aminophenyl)-2-(3-(dimethylamino)propyl)-, hydrochloride,hydrate (1:2:2) chemical structure, C19H25Cl2N3O, CAS 116870-75-8
1H-Isoindol-1-one, 2,3-dihydro-3-(2-aminophenyl)-2-(3-(dimethylamino)propyl)-, hydrochloride,hydrate (1:2:2)
CAS 116870-75-8C19H25Cl2N3O
1H-Isoindol-1-one, 2,3-dihydro-3-(2-aminophenyl)-2-(3-(dibutylamino)propyl)-, hydrochloride, hydrate (1:1:2) chemical structure, C25H36ClN3O, CAS 116870-76-9
1H-Isoindol-1-one, 2,3-dihydro-3-(2-aminophenyl)-2-(3-(dibutylamino)propyl)-, hydrochloride, hydrate (1:1:2)
CAS 116870-76-9C25H36ClN3O
1H-Isoindol-1-one, 2,3-dihydro-2-(2-(diethylamino)ethyl)-3-(2-(dimethylamino)phenyl)-, dihydrochloride chemical structure, C22H31Cl2N3O, CAS 116870-78-1
1H-Isoindol-1-one, 2,3-dihydro-2-(2-(diethylamino)ethyl)-3-(2-(dimethylamino)phenyl)-, dihydrochloride
CAS 116870-78-1C22H31Cl2N3O
1H-Isoindol-1-one, 2,3-dihydro-2-(2-(diethylamino)ethyl)-3-(2-(ethylamino)phenyl)-, hydrochloride, hydrate (5:10:4) chemical structure, C22H31Cl2N3O, CAS 116870-79-2
1H-Isoindol-1-one, 2,3-dihydro-2-(2-(diethylamino)ethyl)-3-(2-(ethylamino)phenyl)-, hydrochloride, hydrate (5:10:4)
CAS 116870-79-2C22H31Cl2N3O
1H-Isoindol-1-one, 2,3-dihydro-3-(2-amino-5-chlorophenyl)-2-(2-(diethylamino)ethyl)-, hydrochloride, hydrate (2:4:1) chemical structure, C20H26Cl3N3O, CAS 116870-81-6
1H-Isoindol-1-one, 2,3-dihydro-3-(2-amino-5-chlorophenyl)-2-(2-(diethylamino)ethyl)-, hydrochloride, hydrate (2:4:1)
CAS 116870-81-6C20H26Cl3N3O