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Analgesics and anti-inflammatories

Clofazimine

Also known as Lamprene, Chlofazimine, Clofazimina

CAS 2030-63-9Formula C27H22Cl2N4Molar mass 473.41 g/molEC 217-980-2
GHS signal word: Warning. Pictograms: Harmful or irritant 95 suppliers listed
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Clofazimine chemical structure, C27H22Cl2N4, CAS 2030-63-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
2030-63-9
Formula
C27H22Cl2N4
Molar mass
473.41 g/mol
EC number
217-980-2
HS code
293399
Category
Analgesics and anti-inflammatories

What is Clofazimine?

Plain description, key identifiers and synonyms

Clofazimine is 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients. It has a role as a non-steroidal anti-inflammatory drug, a leprostatic drug and a dye. It is a member of phenazines and a member of monochlorobenzenes.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N,5-bis(4-chlorophenyl)-3-propan-2-yliminophenazin-2-amine
CAS number
2030-63-9 CAS number cross-checkedOther or deprecated CAS: 2458811-14-6
EC number
217-980-2
Molecular formula
C27H22Cl2N4
UNII
D959AE5USF
MDL number
MFCD00056793
InChIKey
WDQPAMHFFCXSNU-UHFFFAOYSA-N
InChI
InChI=1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3
SMILES (canonical and isomeric)
CC(C)N=C1C=C2C(=NC3=CC=CC=C3N2C4=CC=C(C=C4)Cl)C=C1NC5=CC=C(C=C5)Cl

Synonyms

  • Lamprene
  • Chlofazimine
  • Clofazimina
  • Clofaziminum
  • N,5-bis(4-chlorophenyl)-3-propan-2-yliminophenazin-2-amine
  • Colfazimine
  • 3-(p-Chloranilino)-10-(p-chlorphenyl)-2,10-dihydro-2-(isopropylimino)-phenazin
  • 3-(p-Chloranilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)-phenazine
  • Phenazine, 3-(p-chloroanilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)-
  • 2-Phenazinamine, 3,5-dihydro-N,5-bis(4-chlorophenyl)-3-((1-methylethyl)imino)-
  • 2-Phenazinamine, N,5-bis(4-chlorophenyl)-3,5-dihydro-3-((1-methylethyl)imino)-
  • N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-[(1-methylethyl)imino]-2-phenazinamine
  • 2-Phenazinamine, N,5-bis(4-chlorophenyl)-3,5-dihydro-3-[(1-methylethyl)imino]-
  • N,5-bis(4-chlorophenyl)-3-(propan-2-ylimino)-3,5-dihydrophenazin-2-amine
  • N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-((1-methylethyl)imino)-2-phenazinamine
  • Lampren
  • B 663 (Pharmaceutical)
  • 3-(p-Chloroanilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)phenazine
  • N,5-bis(4-chlorophenyl)-3-(isopropylimino)-3,5-dihydrophenazin-2-amine
  • N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(isopropylimino)phenazin-2-amine
  • Phenazine, 2,10-dihydro-3-(p-chloroanilino)-10-(p-chlorophenyl)-2-(isopropylimino)-
  • C27H22Cl2N4
  • N,5-bis(4-chlorophenyl)-3-[(propan-2-yl)imino]-3,5-dihydrophenazin-2-amine
  • 3-(p-Chloranilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)phenazine
  • Riminophenazine
Show all 32 synonyms
  • B 663 (VAN)
  • Lamprene (TN)
  • B 663, pharmaceutical
  • Clofazimine (JAN/USP/INN)
  • (3E)-N,5-bis(4-chlorophenyl)-3-isopropylimino-phenazin-2-amine
  • Clofazimine RS
  • Clofazimine CRS

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
473.41 g/molcalc.
Exact mass
472.1222 Dacalc.
LogP (octanol/water)
7.49calc.
Topological polar surface area
42.21 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
4calc.
Heavy atoms
33calc.
Rings
5calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.11calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, N=c1cc2n(-c3ccccc3)c3ccccc3nc-2cc1Nc1ccccc1

N=c1cc2n(-c3ccccc3)c3ccccc3nc-2cc1Nc1ccccc1

5 rings, 28 atoms, the 3,5-Dihydro-3-imino-N,5-diphenyl-2-phenazinamine ring system.

18 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
  • H413May cause long lasting harmful effects to aquatic life.
Precautionary statements (17)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Clofazimine suppliers

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Where suppliers are based

95 suppliers in 19 countries

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Clofazimine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Anti-Inflammatory Agents
  • Leprostatic Agents

Roles

  • anti-inflammatory agent
  • anti-inflammatory drug
  • antibacterial agent
  • antibacterial drug
  • antiinfective agent
  • antimicrobial agent
  • antimicrobial drug
  • antimycobacterial drug
  • antirheumatic drug
  • dye
  • leprostatic drug
  • non-steroidal anti-inflammatory drug
  • pharmaceutical

Pharmacology

Clofazimine is an Antimycobacterial.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Clofazimine is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Clofazimine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Clofazimine, based on the data on this page

What is Clofazimine?

Clofazimine is 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group.

What is the CAS number of Clofazimine?

The CAS registry number of Clofazimine is 2030-63-9. Other or deprecated CAS numbers: 2458811-14-6.

What is the molecular formula and weight of Clofazimine?

The molecular formula of Clofazimine is C27H22Cl2N4 and its molar mass is 473.41 g/mol.

What is Clofazimine used for?

Known uses and roles of Clofazimine include anti-inflammatories in pharmaceuticals, antibacterials and antibiotics in pharmaceuticals, anti-inflammatory agent, anti-inflammatory drug, antibacterial agent and 12 more.

Is Clofazimine hazardous?

Clofazimine carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Clofazimine?

Clofazimine is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Clofazimine?

CompoundList lists 95 suppliers of Clofazimine in United States, China, Germany, India and 15 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Clofazimine in India?

6 suppliers in India list Clofazimine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Clofazimine?

Suppliers quote Clofazimine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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