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Central nervous system drugs

Clotiazepam

Also known as Rize, Rizen, Tienor

CAS 33671-46-4Formula C16H15ClN2OSMolar mass 318.83 g/molEC 251-627-3
GHS signal word: Warning. Pictograms: Harmful or irritant, Serious health hazard Prohibited, not for trade
Why it is not for trade
Clotiazepam chemical structure, C16H15ClN2OS, CAS 33671-46-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
33671-46-4
Formula
C16H15ClN2OS
Molar mass
318.83 g/mol
EC number
251-627-3
HS code
293491
Category
Central nervous system drugs

What is Clotiazepam?

Plain description, key identifiers and synonyms

Clotiazepam is an organic molecular entity.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
5-(2-chlorophenyl)-7-ethyl-1-methyl-3H-thieno[2,3-e][1,4]diazepin-2-one
CAS number
33671-46-4 CAS number cross-checked
EC number
251-627-3
Molecular formula
C16H15ClN2OS
UNII
ZCN055599V
InChIKey
CHBRHODLKOZEPZ-UHFFFAOYSA-N
InChI
InChI=1S/C16H15ClN2OS/c1-3-10-8-12-15(11-6-4-5-7-13(11)17)18-9-14(20)19(2)16(12)21-10/h4-8H,3,9H2,1-2H3
SMILES (canonical and isomeric)
CCC1=CC2=C(S1)N(C(=O)CN=C2C3=CC=CC=C3Cl)C

Synonyms

  • Rize
  • Rizen
  • Tienor
  • Clotiazepamum
  • Clozan
  • 5-(o-Chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-2H-thieno(2,3-e)-1,4-diazepin-2-one
  • 5-(2-Chlorophenyl)-7-ethyl-1-methyl-1,3-dihydro-2H-thieno(2,3-e)(1,4)diazepin-2-one
  • 2H-Thieno(2,3-e)-1,4-diazepin-2-one, 5-(2-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-
  • 2H-Thieno[2,3-e]-1,4-diazepin-2-one, 5-(2-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-
  • 5-(2-chlorophenyl)-7-ethyl-1-methyl-1,3-dihydro-2H-thieno[2,3-e][1,4]diazepin-2-one
  • 5-(2-chlorophenyl)-7-ethyl-1-methyl-1H,2H,3H-thieno[2,3-e][1,4]diazepin-2-one
  • 5-(2-chlorophenyl)-7-ethyl-1-methyl-1H,2H,3H-thieno(2,3-e)(1,4)diazepin-2-one
  • Trecalmo
  • Rise
  • 5-(2-chlorophenyl)-7-ethyl-1-methyl-3H-thieno[2,3-e][1,4]diazepin-2-one
  • 2H-Thieno(2,3e)(1,4)-diazepin-2-one, 5-(o-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-
  • Distensan
  • Veratran
  • 2H-Thieno(2,3-e)(1,4)diazepin-2-one, 1,3-dihydro-5-(o-chlorophenyl)-7-ethyl-1-methyl-
  • Clotiazepam (1 mg/mL in Methanol)
  • Clotiazepam (1.0mg/ml in Acetonitrile)
  • Rize (TN)
  • DEA No. 2752
  • Clotiazepam (JP18/INN)
  • Clotiazepam, 1mg/ml in Methanol
Show all 27 synonyms
  • Clotiazepam (1 mg/ml in Acetonitrile)
  • 2H-Thieno[2,3-E]-1,4-diazepine-2-one, 5-(2-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
318.83 g/molcalc.
Exact mass
318.0594 Dacalc.
LogP (octanol/water)
3.78calc.
Topological polar surface area
32.67 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
2calc.
Heavy atoms
21calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.25calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CN=C(c2ccccc2)c2ccsc2N1

O=C1CN=C(c2ccccc2)c2ccsc2N1

3 rings, 17 atoms, the 2H-Thieno[2,3-e]-1,4-diazepin-2-one, 1,3-dihydro-5-phenyl- ring system.

18 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H336May cause drowsiness or dizziness.
  • H361Suspected of damaging fertility or the unborn child.
  • H361fdSuspected of damaging fertility. Suspected of damaging the unborn child.
  • H362May cause harm to breast-fed children.
Precautionary statements (16)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P263Avoid contact during pregnancy and while nursing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P330Rinse mouth.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Clotiazepam suppliers

Trading restrictions apply to this substance

Psychotropic substance

Clotiazepam is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Convention on Psychotropic Substances 1971, HS 2022 subheading 2934.91 (sufentanil and related controlled substances)

Our policy on controlled substances

Clotiazepam price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Industries and functions

Roles

  • anxiolytic drug
  • central nervous system depressant
  • central nervous system drug
  • pharmaceutical
  • psychotropic drug
  • tranquilizing drug

Regulatory status

Inventories, regulations and trade controls that list this substance

Psychotropic substance

Clotiazepam is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Convention on Psychotropic Substances 1971, HS 2022 subheading 2934.91 (sufentanil and related controlled substances)

Our policy on controlled substances

Controls

  • US DEA controlled substance or listed chemical
  • Controlled psychotropic substance

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Clotiazepam is traded under.

HS 2934.91Exact HS code

Aminorex (INN), brotizolam (INN), clotiazepam (INN), cloxazolam (INN), dextromoramide…

World exports in 2024
$18.8M
−15.2% vs 2023, imports $18.8M
2019 to 2024
Top exporters
  1. Italy26.7%
  2. United States25.5%
  3. India * partner reported21.1%
Top importers
  1. Egypt42.6%
  2. Japan11.0%
  3. Denmark6.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Clotiazepam is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Clotiazepam, based on the data on this page

What is Clotiazepam?

Clotiazepam is an organic molecular entity.

What is the CAS number of Clotiazepam?

The CAS registry number of Clotiazepam is 33671-46-4.

What is the molecular formula and weight of Clotiazepam?

The molecular formula of Clotiazepam is C16H15ClN2OS and its molar mass is 318.83 g/mol.

What is Clotiazepam used for?

Use classes: Pharmaceuticals.

Is Clotiazepam hazardous?

Clotiazepam carries the GHS signal word "Warning". Main hazards: harmful if swallowed, may cause drowsiness or dizziness, suspected of damaging fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Clotiazepam?

Clotiazepam is usually classified under HS code 293491 (Aminorex (INN), brotizolam (INN), clotiazepam (INN), cloxazolam (INN), dextromoramide…). This is indicative, confirm it with your customs broker before shipping.

Can I buy Clotiazepam on CompoundList?

No. Clotiazepam is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle Clotiazepam

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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