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Impurities and reference standards

Codeine methyl ether

Also known as Methylcodeine, O(6)-Codeine methyl ether, OCME

CAS 2859-16-7Formula C19H23NO3Molar mass 313.40 g/molEC 220-674-1
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard
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Codeine methyl ether chemical structure, C19H23NO3, CAS 2859-16-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
2859-16-7
Formula
C19H23NO3
Molar mass
313.40 g/mol
EC number
220-674-1
HS code
293499
Category
Impurities and reference standards

What is Codeine methyl ether?

Plain description, key identifiers and synonyms

Codeine methyl ether is a chemical substance with the molecular formula C19H23NO3 and a molar mass of 313.40 g/mol. Its CAS registry number is 2859-16-7. The IUPAC name is (4R,4aR,7S,7aR,12bS)-7,9-dimethoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(4R,4aR,7S,7aR,12bS)-7,9-dimethoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline
CAS number
2859-16-7 CAS number cross-checked
EC number
220-674-1
Molecular formula
C19H23NO3
UNII
15M9MY9A04
InChIKey
HGPQAWTZLJXCTC-SSTWWWIQSA-N
InChI
InChI=1S/C19H23NO3/c1-20-9-8-19-12-5-7-15(22-3)18(19)23-17-14(21-2)6-4-11(16(17)19)10-13(12)20/h4-7,12-13,15,18H,8-10H2,1-3H3/t12-,13+,15-,18-,19-/m0/s1
Canonical SMILES
COc1ccc2c3c1OC1C(OC)C=CC4C(C2)N(C)CCC341
Isomeric SMILES
CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3[C@H](C=C4)OC

Synonyms

  • Methylcodeine
  • O(6)-Codeine methyl ether
  • OCME
  • 6-O-Methyl Codeine
  • Dimethylmorphine
  • (4R,4aR,7S,7aR,12bS)-7,9-dimethoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline
  • O6-Methylcodeine
  • 6-Methoxycodeine
  • Codeine EP Impurity A
  • 6-O-Methyl Codeine (1mg/ml in Acetonitrile)
  • Methyl codeine
  • O-Methylcodeine
  • Morphinan, 7,8-didehydro-4,5-epoxy-3,6-dimethoxy-17-methyl-, (5alpha,6alpha)-
  • Di-O-methylmorphine
  • Morphine Dimethyl Ether
  • (5alpha,6alpha)-7,8-Didehydro-4,5-epoxy-3,6-dimethoxy-17-methylmorphinan
  • Morphinan, 7,8-didehydro-3,6-alpha-dimethoxy-4,5-alpha-epoxy-17-methyl-
  • O-Methylcodeine 0.1 mg/ml in Acetonitrile
  • 6-O-Methyl Codeine (1 mg/ml in Acetonitrile)
  • Codeine monohydrate impurity a
  • 3,6-Dimethoxy-17-methyl-7,8-didehydro-4,5-epoxymorphinan
  • Codeine hydrochloride dihydrate impurity a
  • Codeine phosphate hemihydrate impurity a
  • Codeine phosphate sesquihydrate impurity a
  • (5a,6a)-7,8-didehydro-4,5-epoxy-3,6-dimethoxy-17-methylmorphinan
Show all 30 synonyms
  • 3,6alpha-Dimethoxy-17-methyl-5alpha-7,8-didehydro-4,5-epoxymorphinan
  • Hydrocodone hydrogen tartrate 2.5-hydrate impurity f
  • 4,5alpha-epoxy-3,6alpha-dimethoxy-17-methyl-7,8-didehydromorphinan
  • 7,8-Didehydro-4,5?-epoxy-3,6?-dimethoxy-17-methylmorphinan (O-Methylcodeine)
  • 7,8-Didehydro-4,5alpha-epoxy-3,6alpha-dimethoxy-17-methylmorphinan (O-Methylcodeine)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
313.40 g/molcalc.
Exact mass
313.1678 Dacalc.
LogP (octanol/water)
2.16calc.
Topological polar surface area
30.93 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
2calc.
Heavy atoms
23calc.
Rings
5calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.58calc.
Formal charge
0calc.
Stereocentres
5calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1=CC2C3Cc4cccc5c4C2(CCN3)C(C1)O5

C1=CC2C3Cc4cccc5c4C2(CCN3)C(C1)O5

5 rings, 18 atoms.

246 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H334May cause allergy or asthma symptoms or breathing difficulties if inhaled.
  • H336May cause drowsiness or dizziness.
Precautionary statements (16)
  • P233Keep container tightly closed.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P317If swallowed: Get medical help.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P319Get medical help if you feel unwell.
  • P330Rinse mouth.
  • P342 + P316If experiencing respiratory symptoms: Get emergency medical help immediately.
  • P403Store in a well-ventilated place.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

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Codeine methyl ether price

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Uses and applications

What the substance is used for, by industry and function

Applications are not documented for this substance yet. Suppliers often describe uses on their product pages, linked in the suppliers list above.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Codeine methyl ether is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Codeine methyl ether is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Codeine methyl ether, based on the data on this page

What is Codeine methyl ether?

Codeine methyl ether is a chemical substance with the molecular formula C19H23NO3 and a molar mass of 313.40 g/mol. Its CAS registry number is 2859-16-7. The IUPAC name is (4R,4aR,7S,7aR,12bS)-7,9-dimethoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline.

What is the CAS number of Codeine methyl ether?

The CAS registry number of Codeine methyl ether is 2859-16-7.

What is the molecular formula and weight of Codeine methyl ether?

The molecular formula of Codeine methyl ether is C19H23NO3 and its molar mass is 313.40 g/mol.

Is Codeine methyl ether hazardous?

Codeine methyl ether carries the GHS signal word "Danger". Main hazards: harmful if swallowed, may cause allergy or asthma symptoms or breathing difficulties if inhaled, may cause drowsiness or dizziness. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Codeine methyl ether?

Codeine methyl ether is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Codeine methyl ether?

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What is the price of Codeine methyl ether?

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Guides for buyers

Practical guides that help when you source, ship or handle Codeine methyl ether

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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