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Screening compounds

(-)-Codeine phosphate

Also known as Codeine phosphate, Tricodein, Codeini phosphas

CAS 52-28-8Formula C18H24NO7PMolar mass 397.36 g/molEC 200-137-8
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard Prohibited, not for trade
Why it is not for trade
(-)-Codeine phosphate chemical structure, C18H24NO7P, CAS 52-28-8
2D chemical structure

Key facts

What buyers check first

All properties
Physical form
Crystals
Melting point
220 to 235
Solubility
Greater than or equal to 100 mg/mL at 61 °F
HS code
293499
Category
Screening compounds

What is (-)-Codeine phosphate?

Plain description, key identifiers and synonyms

Codeine Phosphate is the phosphate salt of codeine, a naturally occurring phenanthrene alkaloid and opioid agonist with analgesic, antidiarrheal and antitussive activities. Codeine mimics the actions of endogenous opioids by binding to the opioid receptors at many sites within the central nervous system (CNS). Stimulation of mu-subtype opioid receptors results in a decrease in the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline, in addition, the codeine metabolite morphine induces opening of G-protein-coupled inwardly rectifying potassium (GIRK) channels and blocks the opening of N-type voltage-gated calcium channels, resulting in hyperpolarization and reduced neuronal excitability. Stimulation of gut mu-subtype opioid receptors results in a reduction in intestinal motility and delayed intestinal transit times. Antitussive activity is mediated through codeine's action on the cough center in the medulla.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol, phosphoric acid
CAS number
52-28-8 CAS number cross-checked
EC number
200-137-8
Molecular formula
C18H24NO7P
UNII
2X585M1M3T
InChIKey
WUXLCJZUUHIXFY-FFHNEAJVSA-N
InChI
InChI=1S/C18H21NO3.H3O4P/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19;1-5(2,3)4/h3-6,11-13,17,20H,7-9H2,1-2H3;(H3,1,2,3,4)/t11-,12+,13-,17-,18-;/m0./s1
Canonical SMILES
COc1ccc2c3c1OC1C(O)C=CC4C(C2)N(C)CCC341.O=P(O)(O)O
Isomeric SMILES
CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3[C@H](C=C4)O.OP(=O)(O)O

Synonyms

  • Codeine phosphate
  • Tricodein
  • Codeini phosphas
  • Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5-alpha,6-alpha)-, phosphate
  • Morphinan-6-alpha-ol, 7,8-didehydro-4,5-alpha-epoxy-3-methoxy-17-methyl-, phosphate (1:1)
  • Evacode
  • Galcodine
  • Bepro
  • Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)-, phosphate (salt), hydrate (2:2:1)
  • Codeine phosphate bp
  • Codeine phosphate cii
  • Colrex compound
  • Codeine phosphate anhydrous
  • Ardinex
  • Codeine Phosphate (1mg/ml in Methanol)
  • Codeine Phosphate (anhydrous)
  • Codeine Phosphate CII (1144000)
  • Codeine Phosphate (1 mg/ml in Methanol)
  • Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)-, phosphate (1:1) (salt)
  • (4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol, phosphoric acid
  • 7,8-Didehydro-4,5alpha-epoxy-3-methoxy-17-methylmorphinan-6alpha-ol phosphate (1:1) (salt)
  • Phosphoric acid--3-methoxy-17-methyl-5alpha-7,8-didehydro-4,5-epoxymorphinan-6alpha-ol (1/1)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Physical form
Crystalsexp.
Melting point
220 to 235exp.
Solubility
Greater than or equal to 100 mg/mL at 61 °Fexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
397.36 g/molcalc.
Exact mass
397.129 Dacalc.
LogP (octanol/water)
0.57calc.
Topological polar surface area
119.7 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
1calc.
Heavy atoms
27calc.
Rings
5calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.56calc.
Formal charge
0calc.
Stereocentres
5calc.
Components
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1=CC2C3Cc4cccc5c4C2(CCN3)C(C1)O5

C1=CC2C3Cc4cccc5c4C2(CCN3)C(C1)O5

5 rings, 18 atoms.

246 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H301Toxic if swallowed.
  • H317May cause an allergic skin reaction.
  • H334May cause allergy or asthma symptoms or breathing difficulties if inhaled.
  • H360May damage fertility or the unborn child.
  • H361Suspected of damaging fertility or the unborn child.
Precautionary statements (22)
  • P203Obtain, read and follow all safety instructions before use.
  • P233Keep container tightly closed.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P342 + P316If experiencing respiratory symptoms: Get emergency medical help immediately.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403Store in a well-ventilated place.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

(-)-Codeine phosphate suppliers

Trading restrictions apply to this substance

Controlled or monitored substance

(-)-Codeine phosphate is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

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(-)-Codeine phosphate price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

Regulatory status

Inventories, regulations and trade controls that list this substance

Controlled or monitored substance

(-)-Codeine phosphate is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Our policy on controlled substances

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code (-)-Codeine phosphate is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for (-)-Codeine phosphate is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about (-)-Codeine phosphate, based on the data on this page

What is (-)-Codeine phosphate?

Codeine Phosphate is the phosphate salt of codeine, a naturally occurring phenanthrene alkaloid and opioid agonist with analgesic, antidiarrheal and antitussive activities. Codeine mimics the actions of endogenous opioids by binding to the opioid receptors at many sites within the central nervous system (CNS).

What is the CAS number of (-)-Codeine phosphate?

The CAS registry number of (-)-Codeine phosphate is 52-28-8.

What is the molecular formula and weight of (-)-Codeine phosphate?

The molecular formula of (-)-Codeine phosphate is C18H24NO7P and its molar mass is 397.36 g/mol.

What is (-)-Codeine phosphate used for?

Known uses and roles of (-)-Codeine phosphate include building blocks in research and laboratory and screening compounds in research and laboratory.

Is (-)-Codeine phosphate hazardous?

(-)-Codeine phosphate carries the GHS signal word "Danger". Main hazards: toxic if swallowed, may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of (-)-Codeine phosphate?

(-)-Codeine phosphate is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Can I buy (-)-Codeine phosphate on CompoundList?

No. (-)-Codeine phosphate is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle (-)-Codeine phosphate

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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