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Alkaloids

(+)-Coniine

Also known as (2S)-2-propylpiperidine, Coniine, Conicine

CAS 458-88-8Formula C8H17NMolar mass 127.23 g/molEC 207-282-6
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(+)-Coniine chemical structure, C8H17N, CAS 458-88-8
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless liquid
Melting point
-2 °C
Boiling point
133 °C
Density
0.844-0.848 @ 20 °C/4 °C
Solubility
SOLUBLE IN ALCOHOL, ETHER, ACETONE, BENZENE, AMYL ALCOHOL, SLIGHTLY SOL IN CHLOROFORM, O…
HS code
293979
Category
Alkaloids
Illustrative photo, a 1000 litre IBC tote of clear liquid in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is (+)-Coniine?

Plain description, key identifiers and synonyms

(+)-coniine is a 2-propylpiperidine that has S-configuration. It is an enantiomer of a (-)-coniine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S)-2-propylpiperidine
CAS number
458-88-8 CAS number cross-checked
EC number
207-282-6
Molecular formula
C8H17N
UNII
C479P32L2D
InChIKey
NDNUANOUGZGEPO-QMMMGPOBSA-N
InChI
InChI=1S/C8H17N/c1-2-5-8-6-3-4-7-9-8/h8-9H,2-7H2,1H3/t8-/m0/s1
Canonical SMILES
CCCC1CCCCN1
Isomeric SMILES
CCC[C@H]1CCCCN1

Synonyms

  • (2S)-2-propylpiperidine
  • Coniine
  • Conicine
  • Cicutine
  • (S)-beta-Propylpiperidine
  • Cicutin
  • (S)-(+)-Coniine
  • Coniin
  • Koniin
  • Coniinum
  • Piperidine, 2-propyl-, (S)-
  • D-2-(n-Propyl)piperidine
  • D-Conicine
  • (S)-2-Propylpiperidine
  • 5-20-04-00205 (Beilstein Handbook Reference)
  • d-Coniine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless liquidexp.
Odour
MOUSY ODORexp.
Melting point
-2 °Cexp.
Boiling point
133 °Cexp.
Density
0.844-0.848 @ 20 °C/4 °Cexp.
Solubility
SOLUBLE IN ALCOHOL, ETHER, ACETONE, BENZENE, AMYL ALCOHOL, SLIGHTLY SOL IN CHLOROFORM, ONE ML DISSOLVES IN 90 ML WATER, LESS SOL IN HOT WATER, THE BASE DISSOLVES ABOUT 25% WATER AT ROOM TEMPERATUREexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
127.23 g/molcalc.
Exact mass
127.1361 Dacalc.
LogP (octanol/water)
1.93calc.
Topological polar surface area
12.03 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
2calc.
Heavy atoms
9calc.
Rings
1calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1CCNCC1

C1CCNCC1

1 ring, 6 atoms, the Piperidine ring system.

32,085 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

(+)-Coniine suppliers

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(+)-Coniine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Applications are not documented for this substance yet. Suppliers often describe uses on their product pages, linked in the suppliers list above.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Coniine, Ref no: 290, Annex ref: II/290

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code (+)-Coniine is traded under.

HS 2939.79Indicative HS code

Alkaloids of vegetal origin, other than cocaine, ecgonine, salts, esters and other derivatives, not elsewhere…

World exports in 2024
$701M
+18.9% vs 2023, imports $830M
2019 to 2024
Top exporters
  1. Switzerland * partner reported25.3%
  2. Germany21.4%
  3. India * partner reported14.9%
Top importers
  1. United States20.9%
  2. Germany14.7%
  3. Italy14.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for (+)-Coniine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about (+)-Coniine, based on the data on this page

What is (+)-Coniine?

(+)-coniine is a 2-propylpiperidine that has S-configuration. It is an enantiomer of a (-)-coniine.

What is the CAS number of (+)-Coniine?

The CAS registry number of (+)-Coniine is 458-88-8.

What is the molecular formula and weight of (+)-Coniine?

The molecular formula of (+)-Coniine is C8H17N and its molar mass is 127.23 g/mol.

Is (+)-Coniine hazardous?

No GHS hazard classification for (+)-Coniine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of (+)-Coniine?

(+)-Coniine is usually classified under HS code 293979 (Alkaloids, natural or reproduced by synthesis, and their salts, ethers, esters and other…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy (+)-Coniine?

Post a free request on CompoundList and suppliers of (+)-Coniine will send you quotes. Your contact details stay private until you accept a quote.

What is the price of (+)-Coniine?

Suppliers quote (+)-Coniine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle (+)-Coniine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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