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Screening compounds

Conivaptan

Also known as YM 087, 4'-((4,5-dihydro-2-methylimidazo(4,5-d)(1)benzazepin-6(1H)-yl)carbonyl)-2-biphenylcarboxanilide, [1,1'-Biphenyl]-2-carboxamide, N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-

CAS 210101-16-9Formula C32H26N4O2Molar mass 498.59 g/mol
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Conivaptan chemical structure, C32H26N4O2, CAS 210101-16-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
210101-16-9
Formula
C32H26N4O2
Molar mass
498.59 g/mol
HS code
293399
Category
Screening compounds

What is Conivaptan?

Plain description, key identifiers and synonyms

Conivaptan is the amide resulting from the formal condensation of 4-[(biphenyl-2-ylcarbonyl)amino]benzoic acid with the benzazepine nitrogen of 2-methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine. It is an antagonist for two of the three types of arginine vasopressin (AVP) receptors, V1a and V2. It is used as its hydrochloride salt for the treatment of hyponatraemia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). It has a role as an aquaretic and a vasopressin receptor antagonist.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-[4-(2-methyl-4,5-dihydro-3H-imidazo[4,5-d][1]benzazepine-6-carbonyl)phenyl]-2-phenylbenzamide
CAS number
210101-16-9 CAS number cross-checked
Molecular formula
C32H26N4O2
UNII
0NJ98Y462X
InChIKey
IKENVDNFQMCRTR-UHFFFAOYSA-N
InChI
InChI=1S/C32H26N4O2/c1-21-33-28-19-20-36(29-14-8-7-13-27(29)30(28)34-21)32(38)23-15-17-24(18-16-23)35-31(37)26-12-6-5-11-25(26)22-9-3-2-4-10-22/h2-18H,19-20H2,1H3,(H,33,34)(H,35,37)
SMILES (canonical and isomeric)
CC1=NC2=C(N1)CCN(C3=CC=CC=C32)C(=O)C4=CC=C(C=C4)NC(=O)C5=CC=CC=C5C6=CC=CC=C6

Synonyms

  • YM 087
  • 4'-((4,5-dihydro-2-methylimidazo(4,5-d)(1)benzazepin-6(1H)-yl)carbonyl)-2-biphenylcarboxanilide
  • [1,1'-Biphenyl]-2-carboxamide, N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-
  • (1,1'-biphenyl)-2-carboxamide, N-(4-((4,5-dihydro-2-methylimidazo(4,5-D)(1)benzazepin-6(1H)-yl)carbonyl)phenyl)-
  • 4''-((4,5-dihydro-2-methylimidazo(4,5-D)(1)benzazepin-6(1H)-yl)carbonyl)-2-biphenylcarboxanilide
  • conivaptanum
  • N-(4-((4-methyl-3,5,9-triazatricyclo(8.4.0.0^(2,6))tetradeca-1(10),2(6),3,11,13-pentaen-9-yl)carbonyl)phenyl)-2-phenylbenzamide
  • N-(4-(2-methyl4,5-dihydro-3H-imidazo(5,4-d)(1)benzazepine-6-carbonyl)phenyl)-2-phenylbenzamide
  • N-[4-({4-methyl-3,5,9-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),2(6),3,11,13-pentaen-9-yl}carbonyl)phenyl]-2-phenylbenzamide
  • N-[4-(2-methyl4,5-dihydro-3H-imidazo[5,4-d][1]benzazepine-6-carbonyl)phenyl]-2-phenylbenzamide
  • N-[4-(2-methyl-4,5-dihydro-3H-imidazo[4,5-d][1]benzazepine-6-carbonyl)phenyl]-2-phenylbenzamide
  • Conivaptan (INN)
  • PDSP1_001735
  • PDSP2_001718
  • N-{4-[(2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl}biphenyl-2-carboxamide
  • (1,1'-Biphenyl)-2-carboxamide, N-(4-(4,5-dihydro-2-methylimidazo(4,5-d)(1)benzazepin-6(1H)-yl)carbonyl)phenyl)-
  • 4'-[(2-Methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepin-6-yl)carbonyl]-2-phenylbenzanilide
  • N-(4-{4-methyl-3,5,9-triazatricyclo[8.4.0.0,2,6]tetradeca-1(10),2(6),3,11,13-pentaene-9-carbonyl}phenyl)-[1,1'-biphenyl]-2-carboxamide
  • N-[4-(2-methyl-4,5-dihydro-3H-imidazo[4,5-d][1]benzazepine-6-carbonyl)phenyl]-2-phenyl-benzamide
  • N-[4-(2-Methyl-4,5-dihydroimidazo[4,5-d][1]benzazepine-6(3H)-carbonyl)phenyl][1,1'-biphenyl]-2-carboxamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
498.59 g/molcalc.
Exact mass
498.2056 Dacalc.
LogP (octanol/water)
6.51calc.
Topological polar surface area
78.09 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
4calc.
Heavy atoms
38calc.
Rings
6calc.
Aromatic rings
5calc.
Fraction sp3 carbons
0.09calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(Nc1ccc(C(=O)N2CCc3[nH]cnc3-c3ccccc32)cc1)c1ccccc1-c1ccccc1

O=C(Nc1ccc(C(=O)N2CCc3[nH]cnc3-c3ccccc32)cc1)c1ccccc1-c1ccccc1

6 rings, 37 atoms.

2 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Conivaptan suppliers

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All 2 suppliers

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Where suppliers are based

2 suppliers in 1 country

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Conivaptan price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antidiuretic Hormone Receptor Antagonists

Roles

  • antagonist
  • aquaretic
  • cardiovascular drug
  • diuretic
  • hepatoprotective agent
  • hormone antagonist
  • hormone receptor modulator
  • neuroprotective agent
  • pharmaceutical
  • protective agent
  • receptor modulator
  • vasopressin receptor antagonist

Pharmacology

Conivaptan is a Vasopressin Receptor Antagonist. The mechanism of action of conivaptan is as a Vasopressin Receptor Antagonist and Cytochrome P450 3A Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Conivaptan is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Conivaptan is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Conivaptan, based on the data on this page

What is Conivaptan?

Conivaptan is the amide resulting from the formal condensation of 4-[(biphenyl-2-ylcarbonyl)amino]benzoic acid with the benzazepine nitrogen of 2-methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine. It is an antagonist for two of the three types of arginine vasopressin (AVP) receptors, V1a and V2.

What is the CAS number of Conivaptan?

The CAS registry number of Conivaptan is 210101-16-9.

What is the molecular formula and weight of Conivaptan?

The molecular formula of Conivaptan is C32H26N4O2 and its molar mass is 498.59 g/mol.

What is Conivaptan used for?

Known uses and roles of Conivaptan include building blocks in research and laboratory, screening compounds in research and laboratory, antagonist, aquaretic, cardiovascular drug and 10 more.

Is Conivaptan hazardous?

No GHS hazard classification for Conivaptan is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Conivaptan?

Conivaptan is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Conivaptan?

CompoundList lists 2 suppliers of Conivaptan in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Conivaptan?

Suppliers quote Conivaptan on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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