CompoundList
Sign in
Insecticides and acaricides

Coumaphos

Also known as Coumafos, Asuntol, Meldane

CAS 56-72-4Formula C14H16ClO5PSMolar mass 362.77 g/molEC 200-285-3
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Hazardous to the environment 12 suppliers listed
Get quotes Compare 12 suppliers
Coumaphos chemical structure, C14H16ClO5PS, CAS 56-72-4
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless crystals
Melting point
95.2 °C
Boiling point
20 °C
Density
1.474 g/cm³
Flash point
Not Applicable. Combustible solid.
HS code
293220
Category
Insecticides and acaricides
UN number
UN 3027
Illustrative photo, colourless crystals in small glass vials on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Coumaphos?

Plain description, key identifiers and synonyms

Coumaphos is an organothiophosphate insecticide, an organochlorine compound and an organic thiophosphate. It has a role as an acaricide, an agrochemical, an avicide, an antinematodal drug and an EC 3.1.1.8 (cholinesterase) inhibitor. It is functionally related to a chlorferron.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
3-chloro-7-diethoxyphosphinothioyloxy-4-methylchromen-2-one
CAS number
56-72-4 CAS number cross-checked
EC number
200-285-3
Molecular formula
C14H16ClO5PS
UNII
L08SZ5Z5JC
MDL number
MFCD00041820
InChIKey
BXNANOICGRISHX-UHFFFAOYSA-N
InChI
InChI=1S/C14H16ClO5PS/c1-4-17-21(22,18-5-2)20-10-6-7-11-9(3)13(15)14(16)19-12(11)8-10/h6-8H,4-5H2,1-3H3
SMILES (canonical and isomeric)
CCOP(=S)(OCC)OC1=CC2=C(C=C1)C(=C(C(=O)O2)Cl)C

Synonyms

  • Coumafos
  • Asuntol
  • Meldane
  • Asunthol
  • Muscatox
  • Resitox
  • Baymix
  • Azunthol
  • Agridip
  • Meldone
  • Suntol
  • CO-Ral
  • Cumafos
  • Baymix 50
  • 3-Chloro-4-methyl-7-hydroxycoumarin diethyl thiophosphoric acid ester
  • Diolice
  • Negashunt
  • Umbethion
  • Bayer 21/199
  • Cumafosum
  • Negasunt
  • Bayer 21199
  • Coumafosum
  • Resistox
  • 3-Chloro-4-methyl-7-coumarinyl diethyl phosphorothioate
Show all 39 synonyms
  • BAY 21/199
  • ENT 17,957
  • O,O-Diethyl 3-chloro-4-methyl-7-umbelliferone thiophosphate
  • O,O-Diethyl O-(3-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl)phosphorothioate
  • OMS 485
  • 3-Chloro-7-hydroxy-4-methyl-coumarin O,O-diethyl phosphorothioate
  • Phosphorothioic acid, O-(3-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl) O,O-diethyl ester
  • 3-Chloro-7-diethoxyphosphinothioyloxy-4-methylcoumarin
  • o-(3-Chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl) o,o-diethyl phosphorothioate
  • Coumarin, 3-chloro-7-hydroxy-4-methyl-, O-ester with O,O-diethyl phosphorothioate
  • O-3-Chloro-4-methyl-7-coumarinyl O,O-diethyl phosphorothioate
  • Diethyl 3-chloro-4-methylumbelliferyl thionophosphate
  • O-(3-Chloro-4-methyl-2-oxo-2H-chromen-7-yl) O,O-diethyl thiophosphate
  • O,O-Diethyl O-(3-chloro-4-methylcoumarinyl-7) thiophosphate

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless crystalsexp.
Odour
Slight sulfur-like odorexp.
Melting point
95.2 °Cexp.
Boiling point
20 °Cexp.
Density
1.474 g/cm³exp.
Flash point
Not Applicable. Combustible solid.exp.
Solubility
In water, 1.5 mg/L at 20 °Cexp.
Vapour pressure
0.013 mPa /9.7 × 10⁻⁸ mm Hg/ at 20 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
362.77 g/molcalc.
Exact mass
362.0145 Dacalc.
LogP (octanol/water)
4.43calc.
Topological polar surface area
57.9 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
6calc.
Heavy atoms
22calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.36calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1ccc2ccccc2o1

O=c1ccc2ccccc2o1

2 rings, 11 atoms, the Coumarin ring system.

3,845 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H300Fatal if swallowed.
  • H312Harmful in contact with skin.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (13)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P317Get medical help.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 3027
Transport hazard class
6.1
Packing group
II

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Coumaphos suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 12 suppliers
12 of 12 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

12 suppliers in 6 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Coumaphos price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Insecticide, acaricide.

Non-systemic insecticide for control of Diptera, and for control of Hypoderma on cattle. Also controls parasitic mites (Varroa jacobson) on bees.

Therapeutic category (veterinary): Anthelmintic, ectoparasiticide.

Use classes: Insecticides, Animal Drugs.

Pharmacological actions

  • Anthelmintics
  • Antinematodal Agents
  • Cholinesterase Inhibitors
  • Insecticides

Roles

  • acaricide
  • agrochemical
  • anthelminthic drug
  • antiinfective agent
  • antinematodal drug
  • antiparasitic agent
  • avicide
  • enzyme inhibitor
  • nematicide
  • pesticide
  • pharmaceutical

Functional uses

  • Biocide

Pharmacology

Coumaphos is a synthetic organic thiophosphate, organochlorine compound, and organophosphate acetylcholinesterase inhibitor that is used as a pesticide. It is characterized as a tan or slightly brown crystalline solid with a mild sulfurous odor, and exposure occurs by inhalation, ingestion, or contact.

How it is made

The feed materials for coumaphos manufacture are diethyl phosphorothionochloridate and 3-chloro-4-methyl-7-hydroxy coumarin. ... The reaction is usually carried out in the presence of an acid binding agent such as potassium carbonate. This process is carried out at a reaction temp in the range of 50 deg to 100 °C. This reaction is carried out at atm pressure. Reaction periods of 15 min to several hr are used. This reaction is preferably carried out in the presence of a diluent in which the coumarin is soluble. Particularly suitable solvents of this kind are ketones such as acetone and methyl ethyl ketone.

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 015-038-00-3

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Coumaphos is traded under.

HS 2932.20Indicative HS code

Lactones

World exports in 2024
$1.97B
−4.7% vs 2023, imports $2.07B
2019 to 2024
Top exporters
  1. China56.3%
  2. India * partner reported7.4%
  3. Germany7.3%
Top importers
  1. United States14.2%
  2. India * partner reported13.5%
  3. Brazil8.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Coumaphos is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Coumaphos, based on the data on this page

What is Coumaphos?

Coumaphos is an organothiophosphate insecticide, an organochlorine compound and an organic thiophosphate. It has a role as an acaricide, an agrochemical, an avicide, an antinematodal drug and an EC 3.1.1.8 (cholinesterase) inhibitor. It is functionally related to a chlorferron.

What is the CAS number of Coumaphos?

The CAS registry number of Coumaphos is 56-72-4.

What is the molecular formula and weight of Coumaphos?

The molecular formula of Coumaphos is C14H16ClO5PS and its molar mass is 362.77 g/mol.

What is Coumaphos used for?

Insecticide, acaricide. Non-systemic insecticide for control of Diptera, and for control of Hypoderma on cattle. Also controls parasitic mites (Varroa jacobson) on bees. Therapeutic category (veterinary): Anthelmintic, ectoparasiticide. Use classes: Insecticides, Animal Drugs.

Is Coumaphos hazardous?

Coumaphos carries the GHS signal word "Danger". Main hazards: fatal if swallowed, harmful in contact with skin, very toxic to aquatic life. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Coumaphos?

Coumaphos is usually classified under HS code 293220 (Lactones). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Coumaphos?

CompoundList lists 12 suppliers of Coumaphos in China, United States, Switzerland, France and 2 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Coumaphos?

Suppliers quote Coumaphos on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Coumaphos

Get quotes for Coumaphos

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Coumaphos
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Coumaphos with a 3D view, its CAS number and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/coumaphos-56-72-4" title="Coumaphos structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Insecticides and acaricides or HS code 293220

12 suppliers
Free quotes, contact stays private
Get quotes