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Screening compounds

Crenolanib

Also known as CP-868,596, crenolanibum, ARO 002

CAS 670220-88-9Formula C26H29N5O2Molar mass 443.55 g/mol
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Crenolanib chemical structure, C26H29N5O2, CAS 670220-88-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
670220-88-9
Formula
C26H29N5O2
Molar mass
443.55 g/mol
HS code
293499
Category
Screening compounds

What is Crenolanib?

Plain description, key identifiers and synonyms

Crenolanib is a member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a 8-(4-aminopiperidin-1-yl)quinolin-2-yl group at position 1 and by a (3-methyloxetan-3-yl)methoxy group at position 5. It is an inhibitor of type III tyrosine kinases, PDGFRalpha/beta and FLT3 (IC50 of 11, 3.2, and 4 nM). Currently under clinical development for the treatment of acute myeloid leukemia. It has a role as an antineoplastic agent, an angiogenesis inhibitor, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an apoptosis inducer. It is a member of benzimidazoles, a member of quinolines, an aromatic ether, a member of oxetanes, an aminopiperidine and a tertiary amino compound.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol-1-yl]quinolin-8-yl]piperidin-4-amine
CAS number
670220-88-9 CAS number cross-checked
Molecular formula
C26H29N5O2
UNII
LQF7I567TQ
MDL number
MFCD21609260
InChIKey
DYNHJHQFHQTFTP-UHFFFAOYSA-N
InChI
InChI=1S/C26H29N5O2/c1-26(14-32-15-26)16-33-20-6-7-22-21(13-20)28-17-31(22)24-8-5-18-3-2-4-23(25(18)29-24)30-11-9-19(27)10-12-30/h2-8,13,17,19H,9-12,14-16,27H2,1H3
SMILES (canonical and isomeric)
CC1(COC1)COC2=CC3=C(C=C2)N(C=N3)C4=NC5=C(C=CC=C5N6CCC(CC6)N)C=C4

Synonyms

  • CP-868,596
  • crenolanibum
  • ARO 002
  • 1-(2-{5-[(3-Methyloxetan-3-yl)methoxy]-1H-benzimidazol-1-yl}quinolin-8-yl)piperidin-4-amine
  • 1-(2-{5-[(3-methyloxetan-3-yl)methoxy]-1H-1,3-benzodiazol-1-yl}quinolin-8-yl)piperidin-4-amine
  • 1-(2-(5-((3-methyloxetan-3-yl)methoxy)-1H-1,3-benzodiazol-1-yl)quinolin-8-yl)piperidin-4-amine
  • 1-(2-(5-((3-Methyloxetan-3-yl)methoxy)-1H-benzimidazol-1-yl)quinolin-8-yl)piperidin-4-amine
  • PDGFR Inhibitor CP-868596
  • (1-(2-(5-(3-Methyloxetan-3-ylmethoxy)benzimidazol-1-yl)quinolin-8-yl)piperidin-4-yl)amine
  • 4-Piperidinamine, 1-(2-(5-((3-methyl-3-oxetanyl)methoxy)-1Hbenzimidazol-1-yl)-8-quinolinyl)-
  • Crenolanib (CP-868596)
  • CP 868596
  • 1-[2-[5-[(3-Methyl-3-oxetanyl)methoxy]-1-benzimidazolyl]-8-quinolyl]-4-piperidinamine
  • CP-868596 (Crenolanib)
  • 1-(2-(5-((3-Methyloxetan-3-yl)methoxy)-1H-benzo-[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine
  • 1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol-1-yl]quinolin-8-yl]piperidin-4-amine
  • Crenolanib (USAN)
  • 1-(2-(5-((3-methyloxetan-3-yl)methoxy)-1H-benzo[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine
  • 4-Piperidinamine, 1-[2-[5-[(3-methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-
  • Plarotinib
  • 4-Piperidinamine, 1-(2-(5-((3-methyl-3-oxetanyl)methoxy)-1H-benzimidazol-1-yl)-8-quinolinyl)-
  • Crenolanib,CP-868596
  • CP-868596 (Crenolanib)?
  • Sdccgsbi-0654437.p001
  • 1-(2-(5-((3-methyloxetan-3-yl)methoxy)-1H-benzo[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine.
Show all 30 synonyms
  • 1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol-1-yl]-8-quinolyl]piperidin-4-amine
  • 1-[2-[5-[(3-Methyloxetan-3-yl)methoxy]benzimidazole-1-yl]quinoline-8-yl]piperidin-4-amine
  • 1-(2-{5-[(3-Methyloxetan-3-yl)methoxy]-1H-1,3-benzimidazol-1-yl}quinolin-8-yl)piperidin-4-amine
  • 1-[2-[5-[(3-methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine
  • 1-{2-[5-(3-Methyl-oxetan-3-ylmethoxy)-benzoimidazol-1-yl]-quinolin-8-yl}-piperidin-4-ylamine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
443.55 g/molcalc.
Exact mass
443.2321 Dacalc.
LogP (octanol/water)
3.92calc.
Topological polar surface area
78.43 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
5calc.
Heavy atoms
33calc.
Rings
6calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.39calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1cc(N2CCCCC2)c2nc(-n3cnc4cc(OCC5COC5)ccc43)ccc2c1

c1cc(N2CCCCC2)c2nc(-n3cnc4cc(OCC5COC5)ccc43)ccc2c1

6 rings, 31 atoms.

3 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Crenolanib suppliers

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All 5 suppliers
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Where suppliers are based

5 suppliers in 3 countries

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Crenolanib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antineoplastic Agents

Roles

  • angiogenesis inhibitor
  • antineoplastic agent
  • apoptosis inducer
  • enzyme inhibitor
  • pharmaceutical
  • protein kinase inhibitor
  • tyrosine kinase inhibitor

Pharmacology

Crenolanib is an orally bioavailable benzimidazole targeting the platelet-derived growth factor receptor (PDGFR) subtypes alpha and beta and FMS-related tyrosine kinase 3 (Flt3), with potential antineoplastic activity. Upon oral administration, crenolanib binds to and inhibits both wild-type and mutated forms of PDGFR and Flt3, which may result in the inhibition of PDGFR- and Flt3-related signal transduction pathways. This results in inhibition of tumor angiogenesis and tumor cell proliferation in PDGFR and/or Flt3 overexpressing tumor cells. PDGFR and Flt3, class III receptor tyrosine kinases, are upregulated or mutated in many tumor cell types.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Crenolanib is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Crenolanib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Crenolanib, based on the data on this page

What is Crenolanib?

Crenolanib is a member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a 8-(4-aminopiperidin-1-yl)quinolin-2-yl group at position 1 and by a (3-methyloxetan-3-yl)methoxy group at position 5.

What is the CAS number of Crenolanib?

The CAS registry number of Crenolanib is 670220-88-9.

What is the molecular formula and weight of Crenolanib?

The molecular formula of Crenolanib is C26H29N5O2 and its molar mass is 443.55 g/mol.

What is Crenolanib used for?

Known uses and roles of Crenolanib include building blocks in research and laboratory, screening compounds in research and laboratory, angiogenesis inhibitor, antineoplastic agent, apoptosis inducer and 5 more.

Is Crenolanib hazardous?

No GHS hazard classification for Crenolanib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Crenolanib?

Crenolanib is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Crenolanib?

CompoundList lists 5 suppliers of Crenolanib in China, United States and Canada. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Crenolanib?

Suppliers quote Crenolanib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Crenolanib

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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